Penn State Nittany Lions vs Indiana Hoosiers Prediction & Picks - NCAA

Prediction published on 11/8/25, 8:04 AM  by Travis Pulver | Modified on 1/13/26 at 9:13 AM in NCAA Picks

The No. 2 Indiana Hoosiers will go for the program’s first win in Happy Valley when they take on the struggling Penn State Nittany Lions at Beaver Stadium in University Park, PA, Saturday afternoon. Kickoff for this Big Ten contest is scheduled for 12 p.m. EST. Fans can follow the game on Fox.

Expectations were high for the Nittany Lions coming into the season, and it looked like they might live up to them as they got off to a 3-0 start. But then things quickly fell apart as the team lost five in a row to start Big Ten play, losing their starting quarterback to a season-ending injury and head coach James Franklin (fired). As for Indiana, the journey has been the exact opposite, as they have dominated the competition on both sides of the ball. The Hoosiers have been flying high all season en route to a 9-0 start, becoming the No. 2 team in the first CFP poll. Quarterback Fernando Mendoza has developed into a Heisman front-runner and the popular choice to go No. 1 in the next NFL draft. Should Indiana meet Ohio State in the Big Ten title game as expected, it could be the most anticipated game of the season.