Oregon Ducks vs Indiana Hoosiers Prediction & Picks - NCAA

USA - NCAA

Oregon Ducks
10/11/25 15:30
Indiana Hoosiers

Prediction:

 

Indiana Hoosiers +7.5

-115
$200 offered for betting!

New customers only | Commercial content | 21+ age limit | T&Cs apply

 by Matt Lowrimore | in NCAA Picks

Another one of the huge matchups on the Week 7 Saturday college football slate will feature the 7th-ranked Indiana Hoosiers and the 3rd-ranked Oregon Ducks. Let’s take a look at the match statistics and predictions for this game between the Hoosiers and the Ducks.

Indiana enters this game with a record of 5-0 and 2-0 in the Big Ten. The Hoosiers most recently beat the Iowa Hawkeyes in Week 5 by a score of 20-15. Indiana’s offense had a total of 337 yards. Quarterback Fernando Mendoza threw for 233 yards, two touchdowns, and one interception, while running back Roman Hemby led the team in rushing with 86 yards. 

As for Oregon, they also enter this game with a record of 5-0 and 2-0 in the Big Ten. The Ducks most recently beat the Penn State Nittany Lions in Week 5 by a score of 30-24 in overtime. Oregon’s offense had a total of 424 yards, while its defense allowed 276 yards. Quarterback Dante Moore threw for 248 yards and three touchdowns, while running back Dierre Hill Jr. led the team in rushing with 82 yards.

Up to $200 to bet on Oregon Ducks - Indiana Hoosiers! 

Limited Offer. Currently at DraftKings

Oregon Ducks vs Indiana Hoosiers Form

Table

Oregon Ducks and Indiana Hoosiers Latest Matches

Oregon Ducks
Oregon Ducks Latest matches
W W W W W W
Victories

6/6 (100%)

Defeats

0/6 (0%)

Sep 27, 2025 - NCAA

Penn State Nittany Lions
24 :  30
Oregon Ducks

Sep 20, 2025 - NCAA

Oregon Ducks
41 :  7
Oregon State Beavers

Sep 13, 2025 - NCAA

Northwestern Wildcats
14 :  34
Oregon Ducks

Sep 6, 2025 - NCAA

Oregon Ducks
69 :  3
Oklahoma State Cowboys

Aug 30, 2025 - NCAA

Oregon Ducks
59 :  13
Montana State Bobcats

Oct 4, 2024 - NCAA

Oregon Ducks
31 :  10
Michigan State Spartans
W W W W W
Victories

5/5 (100%)

Defeats

0/5 (0%)

Sep 20, 2025 - NCAA

Oregon Ducks
41 :  7
Oregon State Beavers

Sep 6, 2025 - NCAA

Oregon Ducks
69 :  3
Oklahoma State Cowboys

Aug 30, 2025 - NCAA

Oregon Ducks
59 :  13
Montana State Bobcats

Oct 4, 2024 - NCAA

Oregon Ducks
31 :  10
Michigan State Spartans

Sep 7, 2024 - NCAA

Oregon Ducks
37 :  34
Boise State Broncos
W W W
Victories

3/3 (100%)

Defeats

0/3 (0%)

Sep 27, 2025 - NCAA

Penn State Nittany Lions
24 :  30
Oregon Ducks

Sep 13, 2025 - NCAA

Northwestern Wildcats
14 :  34
Oregon Ducks

Sep 28, 2024 - NCAA

UCLA Bruins
13 :  34
Oregon Ducks
Indiana Hoosiers
Indiana Hoosiers Latest matches
L W W W W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Sep 27, 2025 - NCAA

Iowa Hawkeyes
15 :  20
Indiana Hoosiers

Sep 20, 2025 - NCAA

Indiana Hoosiers
63 :  10
Illinois Fighting Illini

Sep 12, 2025 - NCAA

Indiana Hoosiers
73 :  0
Indiana State Sycamores

Sep 6, 2025 - NCAA

Indiana Hoosiers
56 :  9
Kennesaw State Owls

Aug 30, 2025 - NCAA

Indiana Hoosiers
27 :  14
Old Dominion Monarchs

Dec 20, 2024 - NCAA

Notre Dame Fighting Irish
27 :  17
Indiana Hoosiers
W W W W W W
Victories

6/6 (100%)

Defeats

0/6 (0%)

Sep 20, 2025 - NCAA

Indiana Hoosiers
63 :  10
Illinois Fighting Illini

Sep 12, 2025 - NCAA

Indiana Hoosiers
73 :  0
Indiana State Sycamores

Sep 6, 2025 - NCAA

Indiana Hoosiers
56 :  9
Kennesaw State Owls

Aug 30, 2025 - NCAA

Indiana Hoosiers
27 :  14
Old Dominion Monarchs

Sep 28, 2024 - NCAA

Indiana Hoosiers
42 :  28
Maryland Terrapins

Sep 6, 2024 - NCAA

Indiana Hoosiers
77 :  3
Western Illinois Leathernecks
L W
Victories

1/2 (50%)

Defeats

1/2 (50%)

Sep 27, 2025 - NCAA

Iowa Hawkeyes
15 :  20
Indiana Hoosiers

Dec 20, 2024 - NCAA

Notre Dame Fighting Irish
27 :  17
Indiana Hoosiers

Oregon Ducks - Indiana Hoosiers Key Points

  1. Oregon is 1-1 ATS vs the Big Ten
  2. Oregon is averaging 32.0 points per game vs the Big Ten
  3. Indiana is 1-1 ATS vs the Big Ten
  4. Indiana is averaging 41.5 points per game vs the Big Ten
Up to $200 to bet on Oregon Ducks - Indiana Hoosiers! 

Limited Offer. Currently at DraftKings

Our Oregon Ducks vs Indiana Hoosiers Prediction

Oregon is about a touchdown favorite in this matchup, but Indiana looks to be the better betting option. The Hoosiers have had an explosive offense all season, averaging 47.8 points per game overall. So even though Oregon is also undefeated, the Ducks have not always been efficient and have had some slow starts this season.

This game being in Oregon certainly gives the Ducks an advantage, but Indiana’s offense has been too strong to suggest that they cannot keep this game within a touchdown. Ultimately, an Oregon win is the most likely result; however, our Indiana Hoosiers vs Oregon Ducks prediction is: Indiana Hoosiers +7.5.

Prediction:

 

Indiana Hoosiers +7.5

-115
$200 offered for betting!

All tips are fully researched and given in good faith, but profits cannot be guaranteed.

Oregon Ducks vs Indiana Hoosiers Picks