Ohio State Buckeyes vs Indiana Hoosiers Prediction & Picks - NCAA

USA - NCAA

Ohio State Buckeyes
12/6/25 20:00
Indiana Hoosiers

Prediction:

 

Indiana Hoosiers +4

-110
$300 offered for betting!

New customers only | Commercial content | 21+ age limit | T&Cs apply

 by Matt Lowrimore | in NCAA Picks

Perhaps the most anticipated Conference Championship game will see the 2nd-ranked Indiana Hoosiers take on the 1st-ranked Ohio State Buckeyes. Let’s take a look at the match statistics and predictions for this game between the Hoosiers and the Buckeyes.

Indiana enters this game with a record of 12-0 and finished the regular season 9-0 in the Big Ten. The Hoosiers most recently beat the Purdue Boilermakers in Week 14 by a score of 56-3. Indiana’s offense had a total of 548 yards, while its defense allowed 282 yards. Quarterback Fernando Mendoza threw for 117 yards and two touchdowns, while running back Roman Hemby led the team in rushing with 152 yards and one touchdown.

As for Ohio State, they enter this game with a record of 12-0 and also finished the regular season 9-0 in the Big Ten. The Buckeyes most recently beat the Michigan Wolverines in Week 14 by a score of 27-9. Ohio State’s offense had a total of 419 yards, while its defense allowed 163 yards. Quarterback Julian Sayin threw for 233 yards, three touchdowns, and one interception, while running back Bo Jackson led the team in rushing with 117 yards.

Ohio State Buckeyes vs Indiana Hoosiers Form

Ohio State Buckeyes and Indiana Hoosiers Latest Matches

Ohio State Buckeyes
Ohio State Buckeyes Latest matches
W W W W W W
Victories

6/6 (100%)

Defeats

0/6 (0%)

Nov 29, 2025 - NCAA

Michigan Wolverines
9 :  27
Ohio State Buckeyes

Nov 22, 2025 - NCAA

Ohio State Buckeyes
42 :  9
Rutgers Scarlet Knights

Nov 15, 2025 - NCAA

Ohio State Buckeyes
48 :  10
UCLA Bruins

Nov 8, 2025 - NCAA

Purdue Boilermakers
10 :  34
Ohio State Buckeyes

Nov 1, 2025 - NCAA

Ohio State Buckeyes
38 :  14
Penn State Nittany Lions

Oct 18, 2025 - NCAA

Wisconsin Badgers
0 :  34
Ohio State Buckeyes
W W W W W W
Victories

6/6 (100%)

Defeats

0/6 (0%)

Nov 22, 2025 - NCAA

Ohio State Buckeyes
42 :  9
Rutgers Scarlet Knights

Nov 15, 2025 - NCAA

Ohio State Buckeyes
48 :  10
UCLA Bruins

Nov 1, 2025 - NCAA

Ohio State Buckeyes
38 :  14
Penn State Nittany Lions

Oct 4, 2025 - NCAA

Ohio State Buckeyes
42 :  3
Minnesota Golden Gophers

Sep 13, 2025 - NCAA

Ohio State Buckeyes
37 :  9
Ohio Bobcats

Sep 6, 2025 - NCAA

Ohio State Buckeyes
70 :  0
Grambling State Tigers
W W W W W W
Victories

6/6 (100%)

Defeats

0/6 (0%)

Nov 29, 2025 - NCAA

Michigan Wolverines
9 :  27
Ohio State Buckeyes

Nov 8, 2025 - NCAA

Purdue Boilermakers
10 :  34
Ohio State Buckeyes

Oct 18, 2025 - NCAA

Wisconsin Badgers
0 :  34
Ohio State Buckeyes

Oct 11, 2025 - NCAA

Illinois Fighting Illini
16 :  34
Ohio State Buckeyes

Sep 27, 2025 - NCAA

Washington Huskies
6 :  24
Ohio State Buckeyes

Jan 20, 2025 - NCAA

Notre Dame Fighting Irish
23 :  34
Ohio State Buckeyes
Indiana Hoosiers
Indiana Hoosiers Latest matches
W W W W W W
Victories

6/6 (100%)

Defeats

0/6 (0%)

Nov 28, 2025 - NCAA

Purdue Boilermakers
3 :  56
Indiana Hoosiers

Nov 15, 2025 - NCAA

Indiana Hoosiers
31 :  7
Wisconsin Badgers

Nov 8, 2025 - NCAA

Penn State Nittany Lions
24 :  27
Indiana Hoosiers

Nov 1, 2025 - NCAA

Maryland Terrapins
10 :  55
Indiana Hoosiers

Oct 25, 2025 - NCAA

Indiana Hoosiers
56 :  6
UCLA Bruins

Oct 18, 2025 - NCAA

Indiana Hoosiers
38 :  13
Michigan State Spartans
W W W W W W
Victories

6/6 (100%)

Defeats

0/6 (0%)

Nov 15, 2025 - NCAA

Indiana Hoosiers
31 :  7
Wisconsin Badgers

Oct 25, 2025 - NCAA

Indiana Hoosiers
56 :  6
UCLA Bruins

Oct 18, 2025 - NCAA

Indiana Hoosiers
38 :  13
Michigan State Spartans

Sep 20, 2025 - NCAA

Indiana Hoosiers
63 :  10
Illinois Fighting Illini

Sep 12, 2025 - NCAA

Indiana Hoosiers
73 :  0
Indiana State Sycamores

Sep 6, 2025 - NCAA

Indiana Hoosiers
56 :  9
Kennesaw State Owls
L W W W W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Nov 28, 2025 - NCAA

Purdue Boilermakers
3 :  56
Indiana Hoosiers

Nov 8, 2025 - NCAA

Penn State Nittany Lions
24 :  27
Indiana Hoosiers

Nov 1, 2025 - NCAA

Maryland Terrapins
10 :  55
Indiana Hoosiers

Oct 11, 2025 - NCAA

Oregon Ducks
20 :  30
Indiana Hoosiers

Sep 27, 2025 - NCAA

Iowa Hawkeyes
15 :  20
Indiana Hoosiers

Dec 20, 2024 - NCAA

Notre Dame Fighting Irish
27 :  17
Indiana Hoosiers

Ohio State Buckeyes - Indiana Hoosiers Key Points

  1. Indiana is allowing 12.0 points per game vs the Big Ten
  2. Indiana is averaging 41.8 points per game vs the Big Ten
  3. Ohio State is allowing 8.5 points per game vs the Big Ten
  4. Ohio State is averaging 35.8 points per game vs the Big Ten

Our Ohio State Buckeyes vs Indiana Hoosiers Prediction

Ohio State is the small favorite to win the Big Ten Championship; however, Indiana looks to be the best betting option to keep this game close. The Buckeyes have been dominant all season, averaging 35.8 points per game against Big Ten opponents. More importantly, their defense is allowing just 8.5 points per game against Big Ten opponents. 

If any team is going to score on Ohio State, Indiana looks to be the best candidate. The Hoosiers are averaging nearly 42 points per game against Big Ten opponents, while their defense is allowing an average of 12 points per game.

It is also worth noting that Ohio State’s Offensive Coordinator, Brian Hartline, just accepted a Head Coaching job at South Florida. This likely means he will not be calling the plays in this Championship game, and could have a negative effect on the Buckeyes’ game plan. 

Because these teams look to be evenly matched, our Indiana Hoosiers vs Ohio State Buckeyes prediction is: Indiana Hoosiers +4.

Prediction:

 

Indiana Hoosiers +4

-110
$300 offered for betting!

Claim $300 for your Ohio State Buckeyes vs Indiana Hoosiers wager!

DK Welcome Bonus

Would you like to bet on Ohio State Buckeyes vs Indiana Hoosiers? For this NCAA match, DK treats you to an exclusive offer: a bonus of $300, no promo code needed! Take advantage while you still can!

Not registered yet? You can create your account now with our link below. A bonus of $300 awaits you on the Ohio State Buckeyes vs Indiana Hoosiers match!

$300 available for Ohio State Buckeyes vs Indiana Hoosiers

All tips are fully researched and given in good faith, but profits cannot be guaranteed.

Ohio State Buckeyes vs Indiana Hoosiers Picks