Houston Astros vs Milwaukee Brewers Prediction & Picks - MLB

USA - MLB

Houston Astros
5/6/25 19:40
Milwaukee Brewers

Prediction:

 

Under 8.5

-120
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 by Erik Gibbs in MLB Picks

The Milwaukee Brewers and Houston Astros face off again Tuesday at American Family Field in the second game of their three-game series. The Brewers took the opener on Monday night with a convincing 5-1 win, despite the Astros entering the game as betting favorites.

Milwaukee's offense came alive early, with Brice Turang continuing his impressive start to the season and Christian Yelich providing the big blow with a two-run home run. On the mound, Tobias Myers delivered a strong performance, pitching into the sixth inning while limiting Houston’s offense. The Brewers’ bullpen was equally sharp, with Jared Koenig and Grant Anderson each pitching clean innings and preventing any real scoring threats.

The Astros, on the other hand, struggled to capitalize on opportunities. Despite tallying nine hits, they managed just one run and stranded 15 runners on base. Only three Astros baserunners reached scoring position all game.

Houston’s offensive struggles were compounded by the absence of star slugger Yordan Alvarez, who was placed on the injured list earlier in the day due to inflammation in his right hand. Without Alvarez in the lineup, the Astros’ lineup lacked the firepower needed to keep pace.

Houston Astros vs Milwaukee Brewers Form

Table

Teams % P W L
14
Milwaukee Brewers
Milwaukee Brewers
0.5 36 18 18
14
Houston Astros
Houston Astros
0.5 34 17 17

Houston Astros and Milwaukee Brewers Latest Matches

Houston Astros
Houston Astros Latest matches
L W L W L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

May 5, 2025 - MLB

Houston Astros
1 :  5
Milwaukee Brewers

May 4, 2025 - MLB

Houston Astros
4 :  5
Chicago White Sox

May 3, 2025 - MLB

Houston Astros
8 :  3
Chicago White Sox

May 2, 2025 - MLB

Houston Astros
3 :  7
Chicago White Sox

Apr 30, 2025 - MLB

Detroit Tigers
7 :  4
Houston Astros

Apr 29, 2025 - MLB

Detroit Tigers
4 :  6
Houston Astros
W W W W L W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Apr 30, 2025 - MLB

Detroit Tigers
7 :  4
Houston Astros

Apr 29, 2025 - MLB

Detroit Tigers
4 :  6
Houston Astros

Apr 28, 2025 - MLB

Detroit Tigers
5 :  8
Houston Astros

Apr 23, 2025 - MLB

Toronto Blue Jays
1 :  3
Houston Astros

Apr 22, 2025 - MLB

Toronto Blue Jays
1 :  5
Houston Astros

Apr 21, 2025 - MLB

Toronto Blue Jays
0 :  7
Houston Astros
L W L W L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

May 5, 2025 - MLB

Houston Astros
1 :  5
Milwaukee Brewers

May 4, 2025 - MLB

Houston Astros
4 :  5
Chicago White Sox

May 3, 2025 - MLB

Houston Astros
8 :  3
Chicago White Sox

May 2, 2025 - MLB

Houston Astros
3 :  7
Chicago White Sox

Apr 27, 2025 - MLB

Houston Astros
7 :  3
Kansas City Royals

Apr 26, 2025 - MLB

Houston Astros
0 :  2
Kansas City Royals
Milwaukee Brewers
Milwaukee Brewers Latest matches
W L L L W W
Victories

3/6 (50%)

Defeats

3/6 (50%)

May 5, 2025 - MLB

Houston Astros
1 :  5
Milwaukee Brewers

May 4, 2025 - MLB

Chicago Cubs
0 :  4
Milwaukee Brewers

May 3, 2025 - MLB

Chicago Cubs
6 :  2
Milwaukee Brewers

May 2, 2025 - MLB

Chicago Cubs
10 :  0
Milwaukee Brewers

May 1, 2025 - MLB

Milwaukee Brewers
0 :  8
Chicago White Sox

Apr 30, 2025 - MLB

Milwaukee Brewers
6 :  4
Chicago White Sox
W W L L W W
Victories

3/6 (50%)

Defeats

3/6 (50%)

May 5, 2025 - MLB

Houston Astros
1 :  5
Milwaukee Brewers

May 4, 2025 - MLB

Chicago Cubs
0 :  4
Milwaukee Brewers

May 3, 2025 - MLB

Chicago Cubs
6 :  2
Milwaukee Brewers

May 2, 2025 - MLB

Chicago Cubs
10 :  0
Milwaukee Brewers

Apr 20, 2025 - MLB

Athletics
1 :  14
Milwaukee Brewers

Apr 19, 2025 - MLB

Athletics
3 :  1
Milwaukee Brewers
L L W W W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

May 1, 2025 - MLB

Milwaukee Brewers
0 :  8
Chicago White Sox

Apr 30, 2025 - MLB

Milwaukee Brewers
6 :  4
Chicago White Sox

Apr 29, 2025 - MLB

Milwaukee Brewers
7 :  2
Chicago White Sox

Apr 27, 2025 - MLB

Milwaukee Brewers
7 :  1
St. Louis Cardinals

Apr 26, 2025 - MLB

Milwaukee Brewers
5 :  6
St. Louis Cardinals

Apr 25, 2025 - MLB

Milwaukee Brewers
2 :  3
St. Louis Cardinals

Houston Astros against Milwaukee Brewers : Head to Head (H2H)

Houston Astros

50 %

Milwaukee Brewers

50 %

May 5, 2025 - MLB

Houston Astros
1 :  5
Milwaukee Brewers

May 19, 2024 - MLB

Milwaukee Brewers
4 :  9
Houston Astros

May 18, 2024 - MLB

Milwaukee Brewers
4 :  2
Houston Astros

May 17, 2024 - MLB

Milwaukee Brewers
4 :  5
Houston Astros

Sep 3, 2019 - MLB

Houston Astros
2 :  4
Milwaukee Brewers

Sep 2, 2019 - MLB

Houston Astros
3 :  2
Milwaukee Brewers

Houston Astros - Milwaukee Brewers Key Points

  1. The Brewers are 17-9 covering the run line in their last 26 games
  2. The Brewers are 7-3 ATS in their last 10 games
  3. Of the 4 times the Brewers were listed as moneyline favorites in their last 10 games, they won 3
  4. The Over is 14-19-3 for the Brewers and their opponents this season

Our Houston Astros vs Milwaukee Brewers Prediction

Milwaukee will send Chad Patrick to the mound, while Houston counters with Hayden Wesneski. Patrick will be making his first start of the season, while Wesneski looks to find consistency in his role for the Astros.

While neither Patrick nor Wesneski is a proven starter this season, Patrick is an unknown quantity with upside. Wesneski has shown inconsistency, and the Brewers have been effective at capitalizing on shaky pitching. If Patrick gives Milwaukee 4–5 decent innings, their bullpen — which held Houston scoreless after the sixth in Game 1 — could shut things down again.

Statistically, the Brewers have been the more potent offensive team, ranking 10th in MLB in runs scored. The Astros, in contrast, have struggled to drive in runs, sitting 19th in total offense with just 133 runs scored so far this year.

Given the current momentum and the way both teams are trending, the Brewers appear to have the edge once again. With their offense clicking and the bullpen locking down late innings, Milwaukee is in a good position to take Game 2.

Unless Houston can break out of its offensive slump and find a spark without Alvarez, it may be another tough night. Our prediction for Milwaukee Brewers vs. Houston Astros: Brewers to win.

Prediction:

 

Under 8.5

-120
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Houston Astros vs Milwaukee Brewers Picks