Detroit Tigers vs St. Louis Cardinals Prediction & Picks - MLB

USA - MLB

Detroit Tigers
5/21/25 13:15
St. Louis Cardinals

Prediction:

 

St. Louis Cardinals wins the match

-112
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 by Carlos Zabala in MLB Picks

In the first game of the Cardinals-Tigers series, Gray dominated Detroit's red-hot lineup for the home team. The game, which began as a pitching duel, ended 11-4. The next day, the Tigers brought in Skubal, and the current Cy Young's presence alone boosted the Tigers' odds until they closed around -180 in the pregame action.

In Game 2, Skubal dominated, scoring 4 shutouts in the first 4 innings, while also receiving offensive support from Carpenter and Greene with home runs. However, the Cardinals would have the better at-bats in each of their third at-bats against Skubal, temporarily tying the score at 4-4. Greene would again appear in the clutch for the Tigers, scoring a go-ahead double in the 9th inning. Reliever Will Vest pitched a scoreless inning and earned his 4th win of the season.

The Tigers and Cardinals will play the decisive game of the series early this afternoon at Busch Stadium. Andre Pallante is scheduled to pitch for the home team, putting together two strong outings on May 10 and 16.

Detroit Tigers vs St. Louis Cardinals Form

Table

Teams % P W L
1
Detroit Tigers
Detroit Tigers
0.653 49 32 17
11
St. Louis Cardinals
St. Louis Cardinals
0.551 49 27 22

Detroit Tigers and St. Louis Cardinals Latest Matches

Detroit Tigers
Detroit Tigers Latest matches
W W L W L W
Victories

4/6 (67%)

Defeats

2/6 (33%)

May 20, 2025 - MLB

Detroit Tigers
5 :  4
St. Louis Cardinals

May 19, 2025 - MLB

Detroit Tigers
4 :  11
St. Louis Cardinals

May 18, 2025 - MLB

Detroit Tigers
3 :  2
Toronto Blue Jays

May 17, 2025 - MLB

Detroit Tigers
1 :  2
Toronto Blue Jays

May 16, 2025 - MLB

Detroit Tigers
5 :  4
Toronto Blue Jays

May 14, 2025 - MLB

Boston Red Sox
5 :  6
Detroit Tigers
W L L W W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

May 14, 2025 - MLB

Boston Red Sox
5 :  6
Detroit Tigers

May 13, 2025 - MLB

Boston Red Sox
9 :  10
Detroit Tigers

May 12, 2025 - MLB

Boston Red Sox
2 :  14
Detroit Tigers

May 11, 2025 - MLB

Texas Rangers
6 :  1
Detroit Tigers

May 10, 2025 - MLB

Texas Rangers
10 :  3
Detroit Tigers

May 9, 2025 - MLB

Texas Rangers
1 :  2
Detroit Tigers
W W L W L W
Victories

4/6 (67%)

Defeats

2/6 (33%)

May 20, 2025 - MLB

Detroit Tigers
5 :  4
St. Louis Cardinals

May 19, 2025 - MLB

Detroit Tigers
4 :  11
St. Louis Cardinals

May 18, 2025 - MLB

Detroit Tigers
3 :  2
Toronto Blue Jays

May 17, 2025 - MLB

Detroit Tigers
1 :  2
Toronto Blue Jays

May 16, 2025 - MLB

Detroit Tigers
5 :  4
Toronto Blue Jays

May 8, 2025 - MLB

Detroit Tigers
11 :  1
Colorado Rockies
St. Louis Cardinals
St. Louis Cardinals Latest matches
W W W L W L
Victories

4/6 (67%)

Defeats

2/6 (33%)

May 20, 2025 - MLB

Detroit Tigers
5 :  4
St. Louis Cardinals

May 19, 2025 - MLB

Detroit Tigers
4 :  11
St. Louis Cardinals

May 18, 2025 - MLB

St. Louis Cardinals
1 :  2
Kansas City Royals

May 17, 2025 - MLB

St. Louis Cardinals
1 :  0
Kansas City Royals

May 16, 2025 - MLB

St. Louis Cardinals
10 :  3
Kansas City Royals

May 14, 2025 - MLB

St. Louis Cardinals
14 :  7
Philadelphia Phillies
W W W W W L
Victories

5/6 (83%)

Defeats

1/6 (17%)

May 20, 2025 - MLB

Detroit Tigers
5 :  4
St. Louis Cardinals

May 19, 2025 - MLB

Detroit Tigers
4 :  11
St. Louis Cardinals

May 7, 2025 - MLB

Pittsburgh Pirates
0 :  5
St. Louis Cardinals

May 6, 2025 - MLB

Pittsburgh Pirates
1 :  2
St. Louis Cardinals

May 5, 2025 - MLB

Pittsburgh Pirates
3 :  6
St. Louis Cardinals

May 4, 2025 - MLB

New York Mets
4 :  5
St. Louis Cardinals
W L W W W L
Victories

4/6 (67%)

Defeats

2/6 (33%)

May 18, 2025 - MLB

St. Louis Cardinals
1 :  2
Kansas City Royals

May 17, 2025 - MLB

St. Louis Cardinals
1 :  0
Kansas City Royals

May 16, 2025 - MLB

St. Louis Cardinals
10 :  3
Kansas City Royals

May 14, 2025 - MLB

St. Louis Cardinals
14 :  7
Philadelphia Phillies

May 14, 2025 - MLB

St. Louis Cardinals
1 :  2
Philadelphia Phillies

May 12, 2025 - MLB

St. Louis Cardinals
3 :  2
Philadelphia Phillies

Detroit Tigers against St. Louis Cardinals : Head to Head (H2H)

Detroit Tigers

75 %

St. Louis Cardinals

25 %

May 20, 2025 - MLB

Detroit Tigers
5 :  4
St. Louis Cardinals

May 19, 2025 - MLB

Detroit Tigers
4 :  11
St. Louis Cardinals

Apr 30, 2024 - MLB

St. Louis Cardinals
6 :  11
Detroit Tigers

Sep 10, 2020 - MLB

Detroit Tigers
6 :  3
St. Louis Cardinals

Detroit Tigers - St. Louis Cardinals Key Points

  1. The Cardinals are hitting 9.1 hits per game this season
  2. The Tigers are the second team in MLB with the fewest stolen bases this season
  3. The Cardinals' pitching allows the second fewest home runs this season, with 35
  4. The Cardinals' record at Busch Stadium is 16-7 this season

Our Detroit Tigers vs St. Louis Cardinals Prediction

Pallante has made tremendous improvement in his most recent outings, explained by the fact that the right-hander is inducing more ground balls. In his last two outings, he managed to reach the 7th inning, something he has done three times this season. He didn't issue a walk in both road outings against the Nationals and Royals. Our prediction for Cardinals vs Tigers is: Cardinals ML.

Prediction:

 

St. Louis Cardinals wins the match

-112
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Detroit Tigers vs St. Louis Cardinals Picks