Detroit Tigers vs St. Louis Cardinals Prediction & Picks - MLB

USA - MLB

Detroit Tigers
5/20/25 19:45
St. Louis Cardinals

Prediction:

 

Over 7.5

-105
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 by Erik Gibbs in MLB Picks

The Detroit Tigers and St. Louis Cardinals continue their three-game set on Tuesday after St. Louis opened the series with an emphatic 11-4 win on Monday. Despite that setback, Detroit remains one of the top-performing teams in the American League this season, boasting a 31-16 overall record.

Prior to the series opener, the Tigers had rattled off five straight wins, including a tight one-run victory over the Toronto Blue Jays. Offensively, Detroit has been consistent, carrying a .260 team batting average and generating 253 runs on 418 hits so far this year. Their pitching staff has also been exceptional, with a combined team ERA of 3.21—among the best in the league.

The Cardinals, meanwhile, are six games over .500 and have shown flashes of strong form, though they've dropped two of their last five outings. Their recent loss to the Kansas City Royals snapped a three-game win streak. Offensively, the Cardinals are nearly neck-and-neck with Detroit, batting .262 as a team while recording 224 runs on 421 hits. They’ve also flashed some pop with 45 home runs and a team slugging percentage of .404.

Detroit Tigers vs St. Louis Cardinals Form

Table

Teams % P W L
1
Detroit Tigers
Detroit Tigers
0.646 48 31 17
10
St. Louis Cardinals
St. Louis Cardinals
0.563 48 27 21

Detroit Tigers and St. Louis Cardinals Latest Matches

Detroit Tigers
Detroit Tigers Latest matches
W W W L W L
Victories

4/6 (67%)

Defeats

2/6 (33%)

May 19, 2025 - MLB

Detroit Tigers
4 :  11
St. Louis Cardinals

May 18, 2025 - MLB

Detroit Tigers
3 :  2
Toronto Blue Jays

May 17, 2025 - MLB

Detroit Tigers
1 :  2
Toronto Blue Jays

May 16, 2025 - MLB

Detroit Tigers
5 :  4
Toronto Blue Jays

May 14, 2025 - MLB

Boston Red Sox
5 :  6
Detroit Tigers

May 13, 2025 - MLB

Boston Red Sox
9 :  10
Detroit Tigers
W L L W W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

May 14, 2025 - MLB

Boston Red Sox
5 :  6
Detroit Tigers

May 13, 2025 - MLB

Boston Red Sox
9 :  10
Detroit Tigers

May 12, 2025 - MLB

Boston Red Sox
2 :  14
Detroit Tigers

May 11, 2025 - MLB

Texas Rangers
6 :  1
Detroit Tigers

May 10, 2025 - MLB

Texas Rangers
10 :  3
Detroit Tigers

May 9, 2025 - MLB

Texas Rangers
1 :  2
Detroit Tigers
W W W L W L
Victories

4/6 (67%)

Defeats

2/6 (33%)

May 19, 2025 - MLB

Detroit Tigers
4 :  11
St. Louis Cardinals

May 18, 2025 - MLB

Detroit Tigers
3 :  2
Toronto Blue Jays

May 17, 2025 - MLB

Detroit Tigers
1 :  2
Toronto Blue Jays

May 16, 2025 - MLB

Detroit Tigers
5 :  4
Toronto Blue Jays

May 8, 2025 - MLB

Detroit Tigers
11 :  1
Colorado Rockies

May 8, 2025 - MLB

Detroit Tigers
10 :  2
Colorado Rockies
St. Louis Cardinals
St. Louis Cardinals Latest matches
L W W W L W
Victories

4/6 (67%)

Defeats

2/6 (33%)

May 19, 2025 - MLB

Detroit Tigers
4 :  11
St. Louis Cardinals

May 18, 2025 - MLB

St. Louis Cardinals
1 :  2
Kansas City Royals

May 17, 2025 - MLB

St. Louis Cardinals
1 :  0
Kansas City Royals

May 16, 2025 - MLB

St. Louis Cardinals
10 :  3
Kansas City Royals

May 14, 2025 - MLB

St. Louis Cardinals
14 :  7
Philadelphia Phillies

May 14, 2025 - MLB

St. Louis Cardinals
1 :  2
Philadelphia Phillies
W W W W W W
Victories

6/6 (100%)

Defeats

0/6 (0%)

May 19, 2025 - MLB

Detroit Tigers
4 :  11
St. Louis Cardinals

May 7, 2025 - MLB

Pittsburgh Pirates
0 :  5
St. Louis Cardinals

May 6, 2025 - MLB

Pittsburgh Pirates
1 :  2
St. Louis Cardinals

May 5, 2025 - MLB

Pittsburgh Pirates
3 :  6
St. Louis Cardinals

May 4, 2025 - MLB

New York Mets
4 :  5
St. Louis Cardinals

May 4, 2025 - MLB

New York Mets
5 :  6
St. Louis Cardinals
W L W W W L
Victories

4/6 (67%)

Defeats

2/6 (33%)

May 18, 2025 - MLB

St. Louis Cardinals
1 :  2
Kansas City Royals

May 17, 2025 - MLB

St. Louis Cardinals
1 :  0
Kansas City Royals

May 16, 2025 - MLB

St. Louis Cardinals
10 :  3
Kansas City Royals

May 14, 2025 - MLB

St. Louis Cardinals
14 :  7
Philadelphia Phillies

May 14, 2025 - MLB

St. Louis Cardinals
1 :  2
Philadelphia Phillies

May 12, 2025 - MLB

St. Louis Cardinals
3 :  2
Philadelphia Phillies

Detroit Tigers against St. Louis Cardinals : Head to Head (H2H)

Detroit Tigers

67 %

St. Louis Cardinals

33 %

May 19, 2025 - MLB

Detroit Tigers
4 :  11
St. Louis Cardinals

Apr 30, 2024 - MLB

St. Louis Cardinals
6 :  11
Detroit Tigers

Sep 10, 2020 - MLB

Detroit Tigers
6 :  3
St. Louis Cardinals

Detroit Tigers - St. Louis Cardinals Key Points

  1. The Tigers are 5-1 SU in their last 6 games.
  2. The Tigers are 8-3 SU in their last 11 games vs. the Cardinals
  3. The Over is 13-6 in the Tigers' last 19 games
  4. The Cardinals are 12-2 SU in their last 14 games

Our Detroit Tigers vs St. Louis Cardinals Prediction

Taking the mound for Detroit on Tuesday is Tarik Skubal, the reigning AL Cy Young Award winner. The 28-year-old lefty will be making his 10th start of the season and enters with a 4-2 record. Detroit has come out on top in each of his last four outings, underscoring both his consistency and the team’s confidence when he’s on the mound.

St. Louis counters with Erick Fedde, a 32-year-old right-hander also making his 10th start of the season. Fedde holds a 3-3 record and carries a 3.44 ERA, with 32 strikeouts and 25 walks. However, he’s struggled recently, allowing seven runs against Milwaukee and three more against the Mets in recent appearances.

Adding to Detroit’s advantage is the power threat in their lineup. Hitters like Spencer Torkelson, Riley Greene, and Kerry Carpenter have each tallied more home runs than any single player on the Cardinals roster. With Skubal on the mound and more offensive firepower, Detroit appears poised to bounce back from Monday’s defeat and even the series. Our prediction for St. Louis Cardinals vs. Detroit Tigers: Tigers to win.

Prediction:

 

Over 7.5

-105
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Detroit Tigers vs St. Louis Cardinals Picks