Detroit Tigers vs New York Yankees Prediction & Picks - MLB

Prediction published on 9/10/25, 3:45 PM  by Lou Aguila in MLB Picks

The Detroit Tigers have beaten the New York Yankees in five of their last six meetings.

Listed at +140 moneyline, will the Tigers continue their mastery over the Bronx Bombers on Wednesday at Yankee Stadium?

Current Form:

The Tigers are gradually locking up the No.1 spot in the AL Central with each win they earn this September. At 83-62, Detroit holds an 8.5-game lead on the 74-70 Cleveland Guardians in the division standings. The Tigers’ elite pitching continues to be the team’s biggest weapon, as they have maintained a 3.40 ERA in the last five games. Moreover, Detroit has also raised its run production over this five-game stretch to 7.0 runs on a .229 batting average after scoring 12 runs in Tuesday’s blowout win over the Yankees (12-2).

After beating the Toronto Blue Jays in the final two games of their three-game series, the Yankees could not sustain their strong performance from that series, falling to the Tigers in Game 1 by 10 runs. The loss further put the spotlight on the Yankees’ erratic offense over the last 5 games, during which they have only batted .169 with 3.3 runs per game. New York’s ERA in this stretch has also surged to 5.00 after giving up a combined 19 runs in the two losses they had in this five-game stretch.