Detroit Tigers vs Cleveland Guardians Prediction & Picks - MLB

USA - MLB

Detroit Tigers
9/23/25 18:40
Cleveland Guardians

Prediction:

 

Under 6.5

-105
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 by Carlos Zabala in MLB Picks

Both the Tigers and Guardians rested on Monday, but starting Tuesday, they'll play the most epic series of the final week of MLB regular-season action.

In 2024, when the Tigers positioned themselves as midseason sellers, they also rallied in September with names like Torkelson, Carpenter, and Greene to sneak into the playoffs on the final day. Well, that's what's happening to the Guardians in 2025. On the contrary, AJ Hinch's team, while leading the AL for much of the season, is incredibly close to missing the playoffs, with a dismal September of just 5 wins, losing 9 of their last 10 games and their last 6 after being swept by the Braves in Atlanta.

Like the Tigers, the Guards lost Sunday by the same score of 2-6 against the Twins in Minneapolis, but Cleveland remains the hottest team of the moment; They've won nine of their last 10 games, taken all three games of their series against the Tigers in Detroit, and are in an unbeatable position to wrest the division title from the Tigers starting Tuesday at Progressive Field.

Detroit Tigers vs Cleveland Guardians Form

Table

Teams % P W L
9
Detroit Tigers
Detroit Tigers
0.545 156 85 71
11
Cleveland Guardians
Cleveland Guardians
0.538 156 84 72

Detroit Tigers and Cleveland Guardians Latest Matches

Detroit Tigers
Detroit Tigers Latest matches
L L L L L L
Victories

0/6 (0%)

Defeats

6/6 (100%)

Sep 21, 2025 - MLB

Atlanta Braves
6 :  2
Detroit Tigers

Sep 20, 2025 - MLB

Atlanta Braves
6 :  5
Detroit Tigers

Sep 19, 2025 - MLB

Atlanta Braves
10 :  1
Detroit Tigers

Sep 18, 2025 - MLB

Cleveland Guardians
3 :  1
Detroit Tigers

Sep 17, 2025 - MLB

Cleveland Guardians
4 :  0
Detroit Tigers

Sep 16, 2025 - MLB

Cleveland Guardians
7 :  5
Detroit Tigers
L L L L L L
Victories

0/6 (0%)

Defeats

6/6 (100%)

Sep 21, 2025 - MLB

Atlanta Braves
6 :  2
Detroit Tigers

Sep 20, 2025 - MLB

Atlanta Braves
6 :  5
Detroit Tigers

Sep 19, 2025 - MLB

Atlanta Braves
10 :  1
Detroit Tigers

Sep 18, 2025 - MLB

Cleveland Guardians
3 :  1
Detroit Tigers

Sep 17, 2025 - MLB

Cleveland Guardians
4 :  0
Detroit Tigers

Sep 16, 2025 - MLB

Cleveland Guardians
7 :  5
Detroit Tigers
W W L L L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Sep 14, 2025 - MLB

Detroit Tigers
2 :  0
Miami Marlins

Sep 13, 2025 - MLB

Detroit Tigers
4 :  6
Miami Marlins

Sep 12, 2025 - MLB

Detroit Tigers
2 :  8
Miami Marlins

Sep 11, 2025 - MLB

Detroit Tigers
3 :  9
New York Yankees

Sep 10, 2025 - MLB

Detroit Tigers
11 :  1
New York Yankees

Sep 9, 2025 - MLB

Detroit Tigers
12 :  2
New York Yankees
Cleveland Guardians
Cleveland Guardians Latest matches
W W W W W L
Victories

5/6 (83%)

Defeats

1/6 (17%)

Sep 21, 2025 - MLB

Cleveland Guardians
2 :  6
Minnesota Twins

Sep 20, 2025 - MLB

Cleveland Guardians
8 :  0
Minnesota Twins

Sep 20, 2025 - MLB

Cleveland Guardians
6 :  0
Minnesota Twins

Sep 19, 2025 - MLB

Cleveland Guardians
6 :  2
Minnesota Twins

Sep 18, 2025 - MLB

Cleveland Guardians
3 :  1
Detroit Tigers

Sep 17, 2025 - MLB

Cleveland Guardians
4 :  0
Detroit Tigers
W L W W W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Sep 14, 2025 - MLB

Chicago White Sox
2 :  3
Cleveland Guardians

Sep 13, 2025 - MLB

Chicago White Sox
1 :  3
Cleveland Guardians

Sep 12, 2025 - MLB

Chicago White Sox
0 :  4
Cleveland Guardians

Sep 11, 2025 - MLB

Kansas City Royals
2 :  3
Cleveland Guardians

Sep 10, 2025 - MLB

Kansas City Royals
4 :  3
Cleveland Guardians

Sep 9, 2025 - MLB

Kansas City Royals
0 :  2
Cleveland Guardians
W W W W W L
Victories

5/6 (83%)

Defeats

1/6 (17%)

Sep 21, 2025 - MLB

Cleveland Guardians
2 :  6
Minnesota Twins

Sep 20, 2025 - MLB

Cleveland Guardians
8 :  0
Minnesota Twins

Sep 20, 2025 - MLB

Cleveland Guardians
6 :  0
Minnesota Twins

Sep 19, 2025 - MLB

Cleveland Guardians
6 :  2
Minnesota Twins

Sep 18, 2025 - MLB

Cleveland Guardians
3 :  1
Detroit Tigers

Sep 17, 2025 - MLB

Cleveland Guardians
4 :  0
Detroit Tigers

Detroit Tigers against Cleveland Guardians : Head to Head (H2H)

Detroit Tigers

50 %

Cleveland Guardians

50 %

Sep 18, 2025 - MLB

Cleveland Guardians
3 :  1
Detroit Tigers

Sep 17, 2025 - MLB

Cleveland Guardians
4 :  0
Detroit Tigers

Sep 16, 2025 - MLB

Cleveland Guardians
7 :  5
Detroit Tigers

Jul 6, 2025 - MLB

Detroit Tigers
7 :  2
Cleveland Guardians

Jul 5, 2025 - MLB

Detroit Tigers
1 :  0
Cleveland Guardians

Jul 4, 2025 - MLB

Detroit Tigers
2 :  1
Cleveland Guardians

Detroit Tigers - Cleveland Guardians Key Points

  1. Kwan hit his 11th home run of the year in the Guardians' last loss
  2. Tigers, MLB team with the fewest stolen bases this season
  3. Guards' pitching ERA is the fourth-best in MLB at 3.71.
  4. Tigers, MLB team with the 10th-most home runs this season

Our Detroit Tigers vs Cleveland Guardians Prediction

The situation couldn't be more intense, and Progressive Field is expected to be packed, even on a Tuesday. A.J. Hinch lined up his starting pitching staff to have the reigning Cy Young Award winner and probable Cy Young Award winner this season, the almost infallible Tarik Skubal, pitching Tuesday.

Nothing can be blamed on Skubal for the Tigers' slump; In fact, he is coming off a 6-inning, 102 pitches against the Guardians, with 9 strikeouts and only one earned run.

But the Guards' starting staff has also responded when the moment called for it; Gavin Williams pitched five scoreless innings against the Tigers in Detroit and hopes to do the same on Tuesday.

Our prediction for Tigers vs Guardians is: Under 6.5 runs.

Prediction:

 

Under 6.5

-105
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Detroit Tigers vs Cleveland Guardians Picks