Indianapolis Colts vs Denver Broncos Prediction & Picks - NFL

Prediction published on 9/14/25, 1:02 PM  by Lou Aguila | Modified on 9/16/25 at 5:57 AM in NFL Picks

The Indianapolis Colts and the Denver Broncos clash heads in Week 2 of the NFL season on Sunday at Lucas Oil Stadium.

The Colts are coming in as home underdogs at +110 despite coming off a dominant win over the Miami Dolphins 33-8 in the series opener.

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The Colts opened their season on an emphatic note, crushing the Dolphins by 25 points in week 1. Daniel Jones dazzled in his Colts debut as the quarterback completed 22 of his 29 passes for 272 yards and one TD while rushing for two more touchdowns. Indianapolis showcased its defensive might against Miami, holding the Dolphins to 133 passing yards and 78 rushing yards. They forced Miami quarterback Tua Tagovailoa to complete only 14 of his 23 passes and throw two interceptions.

The Broncos also won their first assignment, thanks to their formidable defense. Denver allowed only 133 total yards in this match while making every play difficult for 2025 No.1 overall pick Cam Ward, who finished with 112 passing yards on a 42.9% completion percentage and zero touchdowns. Denver quarterback Bo Nix threw for 176 yards with one TD, but he completed only 62 percent of his passes and recorded two interceptions. Trailing by 12-10 early in the third quarter, Denver scored the final 10 points of the game with JK Dobbins converting on a 19-yard rushing TD and Wil Lutz scoring on two field-goal attempts.