Daniil Medvedev vs Reilly Opelka Prediction & Picks - ATP Washington Citi Open

Prediction published on 7/23/25, 9:20 AM  by Lou Aguila in Tennis Picks

Reilly Opelka of the United States will take on Daniil Medvedev of Russia in the second round of the 2025 Mubadala CITI Open on Wednesday. The American is gunning for a repeat of his grass-court victory over the former world’s No.1 in 's-Hertogenbosch almost a month ago.

Opelka barged into the second round of the first marquee event in the North American hard-court season, as he outlasted Murphy Cassone 7-6(4) 6-7(5) 6-3 in a thrilling three-set tussle in the first round. Opelka utilized his booming serves to win 53 points off the first serves along with 23 aces. He only conceded one service break in the match while capturing three breakpoints – including a break in the second game of the third set that enabled him to build a decisive 3-0 lead.

Medvedev will be playing in his first match since losing to Benjamin Bonzi of France 7-6(2) 3-6 7-6(3) 6-2 in the first round of the 2025 Wimbledon Open. Medvedev’s early round exit sent shockwaves throughout the tournament, as players and tennis experts alike never expected the two-time Wimbledon Open finalist to crash out in his opening match. However, the return to the hard court offers Medvedev an opportunity to rebuild and gain stronger results on the surface where he has held an outstanding 75 percent win rate throughout his career.