CF Cruz Azul vs CF America Prediction & Picks - Liga MX

Prediction published on 10/18/25, 7:23 PM  by Carlos Zabala | Modified on 10/19/25 at 1:15 AM in Liga MX Picks

América-Cruz Azul has become one of the hottest rivalries in Liga MX, and on October 18th they will face each other in a new edition at the Estadio Olímpico Universitario, with betting odds completely even, in the context of Matchday 13 of Liga MX. América is second in the standings with 27 points, and Cruz Azul is 4th, 2 points behind.

América is coming off a winning streak in its last three league matches: 1-0 against Atlético San Luis, 4-1 against Pumas, and 3-0 against Santos Laguna. Without a doubt, América's standout player has been Zendejas; the American has had a dream season and has recorded at least one goal contribution in each of his last six matches. That's why his absence is especially concerning; due to muscle strain, he will miss the next match against Cruz Azul.

For Brazilian coach André Jardine, their absence is a significant loss, as another América starter, Isaías Violante, will also be out due to injury.

Cruz Azul, on the other hand, is only missing Montano and Argentine Piovi due to an accumulation of yellow cards. After a streak of 7 Liga MX games won in a row, Cruz Azul did not win any of the next 3; the last was a 1-1 draw against Tigres, where Sepúlveda scored a last-minute penalty in the 98th minute.