Colorado Rockies vs San Diego Padres Prediction & Picks - MLB

USA - MLB

Colorado Rockies
9/12/25 21:40
San Diego Padres

Prediction:

 

The Padres -1.5 Runs

-135
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 by Lou Aguila in MLB Picks

The San Diego Padres look to continue their mastery over the Colorado Rockies as they go for another convincing win in Friday’s Game 2 at Petco Park.

The Padres, who are 8-2 in their last 10 meetings with the Rockies, are heavy favorites at -300 and listed at -135 on a -1.5 runline.

Current Form:

San Diego gets back to their winning ways after gutting out a 2-0 win over the Rockies to snap a two-game skid. At 80-67, the Padres are only 2.5 games behind the current NL West leaders, the 82-64 Los Angeles Dodgers.

The Rockies are now 1-9 in September following Thursday’s loss to the Padres. Colorado is the only MLB team this season that has yet to surpass the 40-win threshold.

Offense in the last five games:

San Diego averages 3.5 runs per game on a .218 batting average over their last five games. The Rockies are a lot worse, averaging a pathetic 0.8 runs per game on a .122 BA over their past five assignments.

Pitching & Starters:

San Diego, which has sported an elite 1.96 ERA in the last five games, will start JP Sears. Sears will try to rebound from a lousy stint against the Mariners, where he allowed three earned runs over 3.2 innings in a 6-9 loss.

The Rockies have tapped Tanner Gordon to start on Friday. Gordon is 3-2 with a 7.06 ERA in his last five starts for Colorado, who has posted a 5.49 ERA in the last five games.

Colorado Rockies vs San Diego Padres Form

Table

Teams % P W L
9
San Diego Padres
San Diego Padres
0.544 147 80 67
30
Colorado Rockies
Colorado Rockies
0.272 147 40 107

Colorado Rockies and San Diego Padres Latest Matches

Colorado Rockies
Colorado Rockies Latest matches
L L L L L L
Victories

0/6 (0%)

Defeats

6/6 (100%)

Sep 11, 2025 - MLB

Colorado Rockies
0 :  2
San Diego Padres

Sep 10, 2025 - MLB

Colorado Rockies
0 :  9
Los Angeles Dodgers

Sep 9, 2025 - MLB

Colorado Rockies
2 :  7
Los Angeles Dodgers

Sep 8, 2025 - MLB

Colorado Rockies
1 :  3
Los Angeles Dodgers

Sep 7, 2025 - MLB

San Diego Padres
8 :  1
Colorado Rockies

Sep 6, 2025 - MLB

San Diego Padres
10 :  8
Colorado Rockies
L L L W L L
Victories

1/6 (17%)

Defeats

5/6 (83%)

Sep 7, 2025 - MLB

San Diego Padres
8 :  1
Colorado Rockies

Sep 6, 2025 - MLB

San Diego Padres
10 :  8
Colorado Rockies

Sep 5, 2025 - MLB

San Diego Padres
0 :  3
Colorado Rockies

Sep 3, 2025 - MLB

San Francisco Giants
10 :  8
Colorado Rockies

Sep 2, 2025 - MLB

San Francisco Giants
7 :  4
Colorado Rockies

Sep 1, 2025 - MLB

San Francisco Giants
8 :  2
Colorado Rockies
L L L L L L
Victories

0/6 (0%)

Defeats

6/6 (100%)

Sep 11, 2025 - MLB

Colorado Rockies
0 :  2
San Diego Padres

Sep 10, 2025 - MLB

Colorado Rockies
0 :  9
Los Angeles Dodgers

Sep 9, 2025 - MLB

Colorado Rockies
2 :  7
Los Angeles Dodgers

Sep 8, 2025 - MLB

Colorado Rockies
1 :  3
Los Angeles Dodgers

Aug 28, 2025 - MLB

Colorado Rockies
3 :  4
Houston Astros

Aug 27, 2025 - MLB

Colorado Rockies
0 :  4
Houston Astros
San Diego Padres
San Diego Padres Latest matches
W W W L L W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Sep 11, 2025 - MLB

Colorado Rockies
0 :  2
San Diego Padres

Sep 10, 2025 - MLB

Cincinnati Reds
2 :  1
San Diego Padres

Sep 9, 2025 - MLB

Cincinnati Reds
4 :  2
San Diego Padres

Sep 8, 2025 - MLB

Cincinnati Reds
3 :  4
San Diego Padres

Sep 7, 2025 - MLB

San Diego Padres
8 :  1
Colorado Rockies

Sep 6, 2025 - MLB

San Diego Padres
10 :  8
Colorado Rockies
L L W L L W
Victories

2/6 (33%)

Defeats

4/6 (67%)

Sep 11, 2025 - MLB

Colorado Rockies
0 :  2
San Diego Padres

Sep 10, 2025 - MLB

Cincinnati Reds
2 :  1
San Diego Padres

Sep 9, 2025 - MLB

Cincinnati Reds
4 :  2
San Diego Padres

Sep 8, 2025 - MLB

Cincinnati Reds
3 :  4
San Diego Padres

Sep 3, 2025 - MLB

Baltimore Orioles
7 :  5
San Diego Padres

Sep 2, 2025 - MLB

Baltimore Orioles
6 :  2
San Diego Padres
W L L L W W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Sep 7, 2025 - MLB

San Diego Padres
8 :  1
Colorado Rockies

Sep 6, 2025 - MLB

San Diego Padres
10 :  8
Colorado Rockies

Sep 5, 2025 - MLB

San Diego Padres
0 :  3
Colorado Rockies

Aug 31, 2025 - MLB

San Diego Padres
2 :  7
Minnesota Twins

Aug 30, 2025 - MLB

San Diego Padres
12 :  3
Minnesota Twins

Aug 29, 2025 - MLB

San Diego Padres
4 :  7
Minnesota Twins

Colorado Rockies against San Diego Padres : Head to Head (H2H)

Colorado Rockies

33 %

San Diego Padres

67 %

Sep 11, 2025 - MLB

Colorado Rockies
0 :  2
San Diego Padres

Sep 7, 2025 - MLB

San Diego Padres
8 :  1
Colorado Rockies

Sep 6, 2025 - MLB

San Diego Padres
10 :  8
Colorado Rockies

Sep 5, 2025 - MLB

San Diego Padres
0 :  3
Colorado Rockies

May 11, 2025 - MLB

San Diego Padres
3 :  9
Colorado Rockies

May 10, 2025 - MLB

San Diego Padres
21 :  0
Colorado Rockies

Colorado Rockies - San Diego Padres Key Points

  1. Colorado is 2-8 SU in its last 10 games against San Diego.
  2. Colorado is 0-5 SU in its last 5 games on the road.
  3. San Diego is 4-2 SU in its last 6 games.
  4. San Diego is 6-0 SU in its last 6 games when playing at home against Colorado.

Our Colorado Rockies vs San Diego Padres Prediction

The Padres are a no-brainer pick in this one. The trends and numbers are firmly on their side. Despite their mediocre offense, San Diego remains a formidable World Series contender because of their super elite pitching. Sears has been shaky in his first three mound appearances since joining the Padres, but I expect him to regain his groove and make an impact for San Diego for the remainder of the regular season and into the postseason.

The Rockies’ only two wins over San Diego happened on May 11 (9-3) and last September 5 (3-0). The Padres, who are in a neck-to-neck race with the Dodgers for the NL West title, will certainly not allow it a third time.

Our betting prediction for Colorado Rockies vs. San Diego Padres: the Padres -1.5 Runs

Prediction:

 

The Padres -1.5 Runs

-135
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Colorado Rockies vs San Diego Padres Picks