Houston Cougars vs Colorado Buffaloes Prediction & Picks - NCAA

USA - NCAA

Houston Cougars
9/12/25 19:30
Colorado Buffaloes

Prediction:

 

Houston Cougars ML

-218
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 by Matt Lowrimore | in NCAA Picks

Week 3 of the college football season will feature several games on Friday night, one of which will see the Colorado Buffaloes take on the Houston Cougars in a Big 12 matchup. Let's take a look at the match statistics and predictions for this game between the Buffaloes and Cougars.

Colorado enters this game with a record of 1-1, and this will be their first Big 12 game this season. The Buffaloes most recently beat the Delaware Blue Hens in Week 2 by a score of 31-7. Colorado's offense posted a total of 398 yards, while its defense allowed 396 yards. Quarterback Ryan Staub threw for 157 yards and two touchdowns, while running back Simeon Price led the team in rushing with 55 yards.

As for Houston, they enter this game with a record of 2-0, and this will also be their first game in the Big 12. The Cougars most recently beat the Rice Owls in Week 2 by a score of 35-9. Houston's offense posted a total of 395 yards, while its defense allowed 205 yards. Quarterback Conner Weigman threw for 188 yards and one touchdown, while running back Dean Conners led the team in rushing with 132 yards and two touchdowns.

Houston Cougars vs Colorado Buffaloes Form

Table

Houston Cougars and Colorado Buffaloes Latest Matches

Houston Cougars
Houston Cougars Latest matches
W W
Victories

2/2 (100%)

Defeats

0/2 (0%)

Sep 6, 2025 - NCAA

Rice Owls
9 :  35
Houston Cougars

Aug 28, 2025 - NCAA

Houston Cougars
27 :  0
Stephen F. Austin Lumberjacks
W
Victories

1/1 (100%)

Defeats

0/1 (0%)

Aug 28, 2025 - NCAA

Houston Cougars
27 :  0
Stephen F. Austin Lumberjacks
W
Victories

1/1 (100%)

Defeats

0/1 (0%)

Sep 6, 2025 - NCAA

Rice Owls
9 :  35
Houston Cougars
Colorado Buffaloes
Colorado Buffaloes Latest matches
W W L W L W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Sep 6, 2025 - NCAA

Colorado Buffaloes
31 :  7
Delaware Blue Hens

Aug 29, 2025 - NCAA

Colorado Buffaloes
20 :  27
Georgia Tech Yellow Jackets

Oct 19, 2024 - NCAA

Arizona Wildcats
7 :  34
Colorado Buffaloes

Oct 12, 2024 - NCAA

Colorado Buffaloes
28 :  31
Kansas State Wildcats

Sep 28, 2024 - NCAA

UCF Knights
21 :  48
Colorado Buffaloes

Sep 21, 2024 - NCAA

Colorado Buffaloes
38 :  31
Baylor Bears
W W L L W
Victories

3/5 (60%)

Defeats

2/5 (40%)

Sep 6, 2025 - NCAA

Colorado Buffaloes
31 :  7
Delaware Blue Hens

Aug 29, 2025 - NCAA

Colorado Buffaloes
20 :  27
Georgia Tech Yellow Jackets

Oct 12, 2024 - NCAA

Colorado Buffaloes
28 :  31
Kansas State Wildcats

Sep 21, 2024 - NCAA

Colorado Buffaloes
38 :  31
Baylor Bears

Aug 29, 2024 - NCAA

Colorado Buffaloes
31 :  26
North Dakota State Bison
L W W W
Victories

3/4 (75%)

Defeats

1/4 (25%)

Oct 19, 2024 - NCAA

Arizona Wildcats
7 :  34
Colorado Buffaloes

Sep 28, 2024 - NCAA

UCF Knights
21 :  48
Colorado Buffaloes

Sep 14, 2024 - NCAA

Colorado State Rams
9 :  28
Colorado Buffaloes

Sep 7, 2024 - NCAA

Nebraska Cornhuskers
28 :  10
Colorado Buffaloes

Houston Cougars - Colorado Buffaloes Key Points

  1. Houston is 2-0 ATS this season
  2. Colorado is 1-1 ATS this season
  3. Houston is allowing 4.5 points per game this season
  4. Colorado is allowing an average of 429.5 total yards per game this season

Our Houston Cougars vs Colorado Buffaloes Prediction

Despite winning their Week 2 game against an inferior opponent, the Colorado defense still looks to be a liability. They only allowed seven points in Week 2, but still managed to allow nearly 400 total yards. The Buffaloes' rushing defense did a much better job than in Week 1, where they allowed 320 yards on the ground to Georgia Tech, but their passing defense allowed 312 yards to Delaware.

 As for Houston, their defense has been elite so far this season, having allowed an average of 4.5 points per game through the first two weeks. Additionally, Houston has been balanced offensively this season, plus they will be playing at home in this game. For that reason, our Colorado Buffaloes vs Houston Cougars prediction is: Houston Cougars ML.

Prediction:

 

Houston Cougars ML

-218
$200 offered for betting!

All tips are fully researched and given in good faith, but profits cannot be guaranteed.

Houston Cougars vs Colorado Buffaloes Picks