Cleveland Guardians vs San Francisco Giants Prediction & Picks - MLB

USA - MLB

Cleveland Guardians
6/18/25 21:45
San Francisco Giants

Prediction:

 

Over 8 runs.

+100
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 by Carlos Zabala in MLB Picks

The Guardians ended their losing streak and, after being swept by the Mariners, were able to score a Game 1 victory over the Giants 3-2 in the San Francisco Bay Area. The bullpen performed commendably. Festa, Smith, Gaddis, and Clase combined to get the final 12 outs and claim a victory as betting underdogs, as the Giants had closed as -155 favorites before the first pitch on Tuesday. However, they lost.

The previous game at Oracle Park also saw the warm welcome from Giants fans to Rafael Devers. In the acquisition that shook the entire MLB, the Dominican traveled to the other coast of the United States to meet his new teammates and introduce himself to the press. Within hours, he was batting third for the Giants. He went 2-for-5, struck out twice, but his hit was a double that drove in one of the Giants' two runs.

Veteran Verlander will return to pitching Wednesday for the Giants. He will come off the 15-day IL, is expected to throw around 80 pitches, and will be looking for his first W of the season. Logan Allen, the Guardians' choice to pitch Wednesday, has a 4.28 ERA.

Cleveland Guardians vs San Francisco Giants Form

Table

Teams % P W L
8
San Francisco Giants
San Francisco Giants
0.562 73 41 32
16
Cleveland Guardians
Cleveland Guardians
0.507 71 36 35

Cleveland Guardians and San Francisco Giants Latest Matches

Cleveland Guardians
Cleveland Guardians Latest matches
L W L L L W
Victories

2/6 (33%)

Defeats

4/6 (67%)

Jun 17, 2025 - MLB

Cleveland Guardians
3 :  2
San Francisco Giants

Jun 15, 2025 - MLB

Cleveland Guardians
0 :  6
Seattle Mariners

Jun 14, 2025 - MLB

Cleveland Guardians
3 :  4
Seattle Mariners

Jun 13, 2025 - MLB

Cleveland Guardians
2 :  7
Seattle Mariners

Jun 11, 2025 - MLB

Cincinnati Reds
2 :  11
Cleveland Guardians

Jun 10, 2025 - MLB

Cincinnati Reds
1 :  0
Cleveland Guardians
L L W L L W
Victories

2/6 (33%)

Defeats

4/6 (67%)

Jun 11, 2025 - MLB

Cincinnati Reds
2 :  11
Cleveland Guardians

Jun 10, 2025 - MLB

Cincinnati Reds
1 :  0
Cleveland Guardians

Jun 9, 2025 - MLB

Cincinnati Reds
7 :  4
Cleveland Guardians

Jun 8, 2025 - MLB

Houston Astros
2 :  4
Cleveland Guardians

Jun 7, 2025 - MLB

Houston Astros
5 :  3
Cleveland Guardians

Jun 6, 2025 - MLB

Houston Astros
4 :  2
Cleveland Guardians
W L L L L W
Victories

2/6 (33%)

Defeats

4/6 (67%)

Jun 17, 2025 - MLB

Cleveland Guardians
3 :  2
San Francisco Giants

Jun 15, 2025 - MLB

Cleveland Guardians
0 :  6
Seattle Mariners

Jun 14, 2025 - MLB

Cleveland Guardians
3 :  4
Seattle Mariners

Jun 13, 2025 - MLB

Cleveland Guardians
2 :  7
Seattle Mariners

Jun 5, 2025 - MLB

Cleveland Guardians
0 :  4
New York Yankees

Jun 4, 2025 - MLB

Cleveland Guardians
4 :  0
New York Yankees
San Francisco Giants
San Francisco Giants Latest matches
W L W L L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Jun 17, 2025 - MLB

Cleveland Guardians
3 :  2
San Francisco Giants

Jun 15, 2025 - MLB

San Francisco Giants
4 :  5
Los Angeles Dodgers

Jun 14, 2025 - MLB

San Francisco Giants
5 :  11
Los Angeles Dodgers

Jun 13, 2025 - MLB

San Francisco Giants
6 :  2
Los Angeles Dodgers

Jun 12, 2025 - MLB

San Francisco Giants
7 :  8
Colorado Rockies

Jun 11, 2025 - MLB

San Francisco Giants
10 :  7
Colorado Rockies
W W W W W L
Victories

5/6 (83%)

Defeats

1/6 (17%)

Jun 17, 2025 - MLB

Cleveland Guardians
3 :  2
San Francisco Giants

Jun 8, 2025 - MLB

Atlanta Braves
3 :  4
San Francisco Giants

Jun 7, 2025 - MLB

Atlanta Braves
2 :  3
San Francisco Giants

Jun 6, 2025 - MLB

Atlanta Braves
4 :  5
San Francisco Giants

Jun 5, 2025 - MLB

San Diego Padres
2 :  3
San Francisco Giants

Jun 4, 2025 - MLB

San Diego Padres
5 :  6
San Francisco Giants
W L W W L L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Jun 15, 2025 - MLB

San Francisco Giants
4 :  5
Los Angeles Dodgers

Jun 14, 2025 - MLB

San Francisco Giants
5 :  11
Los Angeles Dodgers

Jun 13, 2025 - MLB

San Francisco Giants
6 :  2
Los Angeles Dodgers

Jun 12, 2025 - MLB

San Francisco Giants
7 :  8
Colorado Rockies

Jun 11, 2025 - MLB

San Francisco Giants
10 :  7
Colorado Rockies

Jun 10, 2025 - MLB

San Francisco Giants
6 :  5
Colorado Rockies

Cleveland Guardians against San Francisco Giants : Head to Head (H2H)

Cleveland Guardians

50 %

San Francisco Giants

50 %

Jun 17, 2025 - MLB

Cleveland Guardians
3 :  2
San Francisco Giants

Mar 21, 2025 - MLB Spring Training

Cleveland Guardians
4 :  5
San Francisco Giants

Mar 12, 2025 - MLB Spring Training

San Francisco Giants
11 :  2
Cleveland Guardians

Jul 7, 2024 - MLB

San Francisco Giants
4 :  5
Cleveland Guardians

Jul 6, 2024 - MLB

San Francisco Giants
4 :  5
Cleveland Guardians

Jul 5, 2024 - MLB

San Francisco Giants
4 :  2
Cleveland Guardians

Cleveland Guardians - San Francisco Giants Key Points

  1. Giants' ERA is the third-best in MLB at 3.27
  2. The Giants' pitching has the second-fewest HRs allowed in 2025
  3. Devers is hitting 504 slugging percentage this season
  4. Giants struck out 10 times in Game 1 against the Guardians

Our Cleveland Guardians vs San Francisco Giants Prediction

Tuesday was undoubtedly a great game. Clase managed to record another save despite allowing the bases to be loaded. He managed to strike out Casey Schmidt with the bases loaded to win the game. Wednesday's pitching duel between Allen and Verlander certainly looks like a good one for both teams to hit and run. In 2 of the Giants' 3 games in their last two series, the games resulted in a Game Total of OVER. Our prediction for Giants vs Guardians is: Over 8 runs.

Prediction:

 

Over 8 runs.

+100
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Cleveland Guardians vs San Francisco Giants Picks