Cleveland Guardians vs Minnesota Twins Prediction & Picks - MLB

USA - MLB

Cleveland Guardians
5/21/25 14:40
Minnesota Twins

Prediction:

 

Twins will win

-118
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 by Lou Aguila in MLB Picks

The Minnesota Twins will slug it out with the Cleveland Guardians on the back of a double-header on Wednesday at Target Field.

The Twins will march into Wednesday’s double-header schedule with a 1-4 record over their last 5 games. Minnesota’s 13-game win streak came to an end at the hands of the Milwaukee Brewers 2-5 on Sunday, and they are trying to avoid back-to-back defeats when Game 1 of their series against the Guardians resume on Wednesday after it was postponed in the fourth inning due to rain.

The Guardians are seeking their first win in five games after last week’s slump extended over the weekend. Cleveland’s level play on the mound and behind the plate has significantly dropped over their last five games, during which they have batted .226 with 2.6 runs per game and pitched a 4.29 ERA.

Cleveland Guardians vs Minnesota Twins Form

Table

Teams % P W L
10
Minnesota Twins
Minnesota Twins
0.553 47 26 21
12
Cleveland Guardians
Cleveland Guardians
0.543 46 25 21

Cleveland Guardians and Minnesota Twins Latest Matches

Cleveland Guardians
Cleveland Guardians Latest matches
W W L L L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

May 18, 2025 - MLB

Cleveland Guardians
1 :  3
Cincinnati Reds

May 17, 2025 - MLB

Cleveland Guardians
1 :  4
Cincinnati Reds

May 16, 2025 - MLB

Cleveland Guardians
4 :  5
Cincinnati Reds

May 14, 2025 - MLB

Milwaukee Brewers
9 :  5
Cleveland Guardians

May 13, 2025 - MLB

Milwaukee Brewers
0 :  2
Cleveland Guardians

May 12, 2025 - MLB

Milwaukee Brewers
0 :  5
Cleveland Guardians
W L L W W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

May 14, 2025 - MLB

Milwaukee Brewers
9 :  5
Cleveland Guardians

May 13, 2025 - MLB

Milwaukee Brewers
0 :  2
Cleveland Guardians

May 12, 2025 - MLB

Milwaukee Brewers
0 :  5
Cleveland Guardians

May 11, 2025 - MLB

Philadelphia Phillies
3 :  0
Cleveland Guardians

May 10, 2025 - MLB

Philadelphia Phillies
7 :  1
Cleveland Guardians

May 9, 2025 - MLB

Philadelphia Phillies
0 :  6
Cleveland Guardians
L W W L L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

May 18, 2025 - MLB

Cleveland Guardians
1 :  3
Cincinnati Reds

May 17, 2025 - MLB

Cleveland Guardians
1 :  4
Cincinnati Reds

May 16, 2025 - MLB

Cleveland Guardians
4 :  5
Cincinnati Reds

May 7, 2025 - MLB

Cleveland Guardians
8 :  6
Washington Nationals

May 6, 2025 - MLB

Cleveland Guardians
9 :  1
Washington Nationals

May 6, 2025 - MLB

Cleveland Guardians
9 :  10
Washington Nationals
Minnesota Twins
Minnesota Twins Latest matches
W W W W W L
Victories

5/6 (83%)

Defeats

1/6 (17%)

May 18, 2025 - MLB

Minnesota Twins
2 :  5
Milwaukee Brewers

May 17, 2025 - MLB

Minnesota Twins
7 :  0
Milwaukee Brewers

May 16, 2025 - MLB

Minnesota Twins
3 :  0
Milwaukee Brewers

May 15, 2025 - MLB

Minnesota Twins
4 :  0
Baltimore Orioles

May 14, 2025 - MLB

Minnesota Twins
8 :  6
Baltimore Orioles

May 14, 2025 - MLB

Minnesota Twins
6 :  3
Baltimore Orioles
W W W W W W
Victories

6/6 (100%)

Defeats

0/6 (0%)

May 11, 2025 - MLB

San Francisco Giants
6 :  7
Minnesota Twins

May 10, 2025 - MLB

San Francisco Giants
1 :  2
Minnesota Twins

May 9, 2025 - MLB

San Francisco Giants
1 :  3
Minnesota Twins

May 8, 2025 - MLB

Baltimore Orioles
2 :  5
Minnesota Twins

May 7, 2025 - MLB

Baltimore Orioles
2 :  5
Minnesota Twins

May 6, 2025 - MLB

Baltimore Orioles
1 :  9
Minnesota Twins
W W W W W L
Victories

5/6 (83%)

Defeats

1/6 (17%)

May 18, 2025 - MLB

Minnesota Twins
2 :  5
Milwaukee Brewers

May 17, 2025 - MLB

Minnesota Twins
7 :  0
Milwaukee Brewers

May 16, 2025 - MLB

Minnesota Twins
3 :  0
Milwaukee Brewers

May 15, 2025 - MLB

Minnesota Twins
4 :  0
Baltimore Orioles

May 14, 2025 - MLB

Minnesota Twins
8 :  6
Baltimore Orioles

May 14, 2025 - MLB

Minnesota Twins
6 :  3
Baltimore Orioles

Cleveland Guardians against Minnesota Twins : Head to Head (H2H)

Cleveland Guardians

83 %

Minnesota Twins

17 %

May 1, 2025 - MLB

Minnesota Twins
3 :  4
Cleveland Guardians

Apr 30, 2025 - MLB

Minnesota Twins
2 :  4
Cleveland Guardians

Apr 29, 2025 - MLB

Minnesota Twins
1 :  2
Cleveland Guardians

Apr 28, 2025 - MLB

Minnesota Twins
11 :  1
Cleveland Guardians

Sep 19, 2024 - MLB

Minnesota Twins
2 :  3
Cleveland Guardians

Sep 18, 2024 - MLB

Minnesota Twins
4 :  5
Cleveland Guardians

Cleveland Guardians - Minnesota Twins Key Points

  1. Minnesota is 9-0 SU in its last 9 games at home.
  2. Cleveland is 1-4 SU in its last 5 games.
  3. Cleveland is 2-4 SU in its last 6 games on the road.
  4. Minnesota is 13-1 SU in its last 14 games.

Our Cleveland Guardians vs Minnesota Twins Prediction

Fearless Forecast: Minnesota takes Game 2 with another dazzling game from Chris Paddack

Why we should bet on the Twins to win: Minnesota is starting Chris Paddack (2.15 ERA), who pitched the Twins to a win in his last 3 starts. Despite losing his first two starts vs. the Guardians, Paddack actually played decently as he allowed a total of 3 earned runs in 13.0 total pitched innings.

Why we should NOT bet on the Guardians to win: Apart from they are only 11-13 on the road this season, Cleveland is averaging 2.7 runs per game over their last five games, which should be a cause for concern for a team that is also struggling to contain opponents. Wednesday’s starter, Gavin Williams, allowed two earned runs in a 5-9 loss to the Brewers and threw 4 earned runs in a 4-11 loss to Minnesota on April 28.

Our betting prediction for the Minnesota Twins vs. the Cleveland Guardians: The Twins will win.

Prediction:

 

Twins will win

-118
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Cleveland Guardians vs Minnesota Twins Picks