Cleveland Guardians vs Boston Red Sox Prediction & Picks - MLB

USA - MLB

Cleveland Guardians
9/2/25 18:45
Boston Red Sox

Prediction:

 

Red Sox -1.5 Runs

-122
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 by Lou Aguila in MLB Picks

The Boston Red Sox seek back-to-back wins over the Cleveland Guardians in Tuesday’s Game 2 at Fenway Park.

The Red Sox, who are 75-64 against the spread this season, pay $100 for every $122 bet if they cover a -1.5-run handicap in this upcoming game.

Current Form:

The Red Sox will try to win their third straight game after beating the Pittsburgh Pirates 5-2 in their series finale and the Guardians 6-4 in Game 1. Boston has been a consistently strong pitching team this season, but their ERA has slightly increased to 4.20 from a season average of 3.80 after surrendering 22 runs in its last five games.

The Guardians are 3-2 in their last five games, but have suffered back-to-back losses to the Mariners 2-4 and the Red Sox 6-4. Cleveland’s offense remains mediocre at best, averaging 3.9 runs per game on a .199 batting average. At 68-68, Cleveland is four games off the current holder of the final wild card spot in the American League, the Seattle Mariners, who carry a 73-65 record.

Boston has topped Cleveland in their last three meetings. The Red Sox have outgunned the Guardians in these three wins, averaging 8.67 runs per game and holding Cleveland to 3.33 runs per contest. Moreover, the Red Sox will dispatch lefty Garrett Crochet, who boasts 3.19 ERA over his last five starts. Cleveland is only hitting .218 with 3.7 runs per game against lefties this season.

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Cleveland Guardians vs Boston Red Sox Form

Table

Teams % P W L
8
Boston Red Sox
Boston Red Sox
0.554 139 77 62
16
Cleveland Guardians
Cleveland Guardians
0.5 136 68 68

Cleveland Guardians and Boston Red Sox Latest Matches

Cleveland Guardians
Cleveland Guardians Latest matches
W W W W L L
Victories

4/6 (67%)

Defeats

2/6 (33%)

Sep 1, 2025 - MLB

Cleveland Guardians
4 :  6
Boston Red Sox

Aug 31, 2025 - MLB

Seattle Mariners
4 :  2
Cleveland Guardians

Aug 30, 2025 - MLB

Seattle Mariners
3 :  4
Cleveland Guardians

Aug 29, 2025 - MLB

Seattle Mariners
4 :  5
Cleveland Guardians

Aug 27, 2025 - MLB

Tampa Bay Rays
3 :  4
Cleveland Guardians

Aug 26, 2025 - MLB

Tampa Bay Rays
0 :  3
Cleveland Guardians
L W W W W L
Victories

4/6 (67%)

Defeats

2/6 (33%)

Aug 31, 2025 - MLB

Seattle Mariners
4 :  2
Cleveland Guardians

Aug 30, 2025 - MLB

Seattle Mariners
3 :  4
Cleveland Guardians

Aug 29, 2025 - MLB

Seattle Mariners
4 :  5
Cleveland Guardians

Aug 27, 2025 - MLB

Tampa Bay Rays
3 :  4
Cleveland Guardians

Aug 26, 2025 - MLB

Tampa Bay Rays
0 :  3
Cleveland Guardians

Aug 25, 2025 - MLB

Tampa Bay Rays
9 :  0
Cleveland Guardians
L L L L L L
Victories

0/6 (0%)

Defeats

6/6 (100%)

Sep 1, 2025 - MLB

Cleveland Guardians
4 :  6
Boston Red Sox

Aug 24, 2025 - MLB

Cleveland Guardians
0 :  5
Texas Rangers

Aug 23, 2025 - MLB

Cleveland Guardians
0 :  10
Texas Rangers

Aug 22, 2025 - MLB

Cleveland Guardians
3 :  4
Texas Rangers

Aug 20, 2025 - MLB

Cleveland Guardians
2 :  3
Arizona Diamondbacks

Aug 19, 2025 - MLB

Cleveland Guardians
5 :  6
Arizona Diamondbacks
Boston Red Sox
Boston Red Sox Latest matches
W W L L W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Sep 1, 2025 - MLB

Cleveland Guardians
4 :  6
Boston Red Sox

Aug 31, 2025 - MLB

Pittsburgh Pirates
2 :  5
Boston Red Sox

Aug 30, 2025 - MLB

Pittsburgh Pirates
10 :  3
Boston Red Sox

Aug 29, 2025 - MLB

Pittsburgh Pirates
4 :  2
Boston Red Sox

Aug 28, 2025 - MLB

Boston Red Sox
3 :  2
Baltimore Orioles

Aug 27, 2025 - MLB

Boston Red Sox
3 :  2
Baltimore Orioles
L L L L W W
Victories

2/6 (33%)

Defeats

4/6 (67%)

Sep 1, 2025 - MLB

Cleveland Guardians
4 :  6
Boston Red Sox

Aug 31, 2025 - MLB

Pittsburgh Pirates
2 :  5
Boston Red Sox

Aug 30, 2025 - MLB

Pittsburgh Pirates
10 :  3
Boston Red Sox

Aug 29, 2025 - MLB

Pittsburgh Pirates
4 :  2
Boston Red Sox

Aug 19, 2025 - MLB

Baltimore Orioles
4 :  3
Boston Red Sox

Aug 18, 2025 - MLB

Baltimore Orioles
6 :  3
Boston Red Sox
W L W W W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Aug 28, 2025 - MLB

Boston Red Sox
3 :  2
Baltimore Orioles

Aug 27, 2025 - MLB

Boston Red Sox
3 :  2
Baltimore Orioles

Aug 26, 2025 - MLB

Boston Red Sox
5 :  0
Baltimore Orioles

Aug 25, 2025 - MLB

Boston Red Sox
4 :  3
Baltimore Orioles

Aug 24, 2025 - MLB

Boston Red Sox
2 :  7
New York Yankees

Aug 23, 2025 - MLB

Boston Red Sox
12 :  1
New York Yankees

Cleveland Guardians against Boston Red Sox : Head to Head (H2H)

Cleveland Guardians

33 %

Boston Red Sox

67 %

Sep 1, 2025 - MLB

Cleveland Guardians
4 :  6
Boston Red Sox

Apr 27, 2025 - MLB

Boston Red Sox
13 :  3
Cleveland Guardians

Apr 26, 2025 - MLB

Boston Red Sox
7 :  3
Cleveland Guardians

Apr 26, 2025 - MLB

Boston Red Sox
4 :  5
Cleveland Guardians

Apr 25, 2024 - MLB

Boston Red Sox
4 :  6
Cleveland Guardians

Apr 24, 2024 - MLB

Boston Red Sox
8 :  0
Cleveland Guardians

Cleveland Guardians - Boston Red Sox Key Points

  1. Cleveland is 0-6 SU in its last 6 games on the road.
  2. Cleveland is 5-11 SU in its last 16 games.
  3. Boston is 9-3 SU in its last 12 games.
  4. Boston is 5-0 SU in its last 5 games against an opponent in the American League.
Up to 500+ to bet on Cleveland Guardians - Boston Red Sox! 

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Our Cleveland Guardians vs Boston Red Sox Prediction

Boston has topped Cleveland in their last three meetings. The Red Sox have outgunned the Guardians in these three wins, averaging 8.67 runs per game and holding Cleveland to 3.33 runs per contest. Moreover, the Red Sox will dispatch lefty Garrett Crochet, who boasts 3.19 ERA over his last five starts. Cleveland is only hitting .218 with 3.7 runs per game against lefties this season.

As for the Guardians, they are 5-11 SU in its last 16 games and 0-6 SU in its last 6 games on the road. Tuesday’s starter, Slade Cecconi is sporting a 6.61 ERA across his last five starts. Cleveland’s bullpen, which is pitching a 2.81 ERA over the last five games, has been the lone bright spot for the team recently. However, dealing with a lethargic offense and six consecutive losses on the road, the Guardians face a difficult task of topping a Red Sox team that has outplayed them in their last three meetings.

Our betting prediction for the Cleveland Guardians vs. the Boston Red Sox: the Red Sox will cover -1.5 Runs.

Prediction:

 

Red Sox -1.5 Runs

-122
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All tips are fully researched and given in good faith, but profits cannot be guaranteed.

Cleveland Guardians vs Boston Red Sox Picks
Up to 500+ to bet on Cleveland Guardians - Boston Red Sox! 

Limited Offer. Currently at Caesars Sportsbook