Cleveland Guardians vs Arizona Diamondbacks Prediction & Picks - MLB

USA - MLB

Cleveland Guardians
8/20/25 15:40
Arizona Diamondbacks

Prediction:

 

Under 9 runs.

-110
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 by Stephen Abiola in MLB Picks

Arizona Diamondbacks (61-66) will look to continue their improvement this month when they take on Cleveland Guardians (64-61) on Wednesday evening. The Diamondbacks, who have averaged 5.4 runs per contest in August, will want to wrap up this three-game series with a win after recovering from a 3-1 loss in the first game to defeat the Guardians 6-5 on Tuesday night. The D-Backs are 5-5 in their previous 10 assignments, sitting fourth in the NL West.

The Guardians, meanwhile, are in dire need of a series win after being swept aside 3-0 by Atlanta in their previous assignment. Their 64-61 record is good for third in the AL Central division, and they are just 0.5 games behind the Royals in second place. However, the Royals are currently playing beautiful baseball, and the Guardians must improve quickly to pip them to the coveted second spot. They don’t have any new injuries ahead of the clash against the D-Backs.

Cleveland Guardians vs Arizona Diamondbacks Form

Table

Teams % P W L
15
Cleveland Guardians
Cleveland Guardians
0.512 125 64 61
20
Arizona Diamondbacks
Arizona Diamondbacks
0.48 127 61 66

Cleveland Guardians and Arizona Diamondbacks Latest Matches

Cleveland Guardians
Cleveland Guardians Latest matches
W L L L W L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Aug 19, 2025 - MLB

Cleveland Guardians
5 :  6
Arizona Diamondbacks

Aug 18, 2025 - MLB

Cleveland Guardians
3 :  1
Arizona Diamondbacks

Aug 17, 2025 - MLB

Atlanta Braves
5 :  4
Cleveland Guardians

Aug 16, 2025 - MLB

Atlanta Braves
10 :  1
Cleveland Guardians

Aug 15, 2025 - MLB

Atlanta Braves
2 :  0
Cleveland Guardians

Aug 14, 2025 - MLB

Miami Marlins
4 :  9
Cleveland Guardians
W L W L L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Aug 17, 2025 - MLB

Atlanta Braves
5 :  4
Cleveland Guardians

Aug 16, 2025 - MLB

Atlanta Braves
10 :  1
Cleveland Guardians

Aug 15, 2025 - MLB

Atlanta Braves
2 :  0
Cleveland Guardians

Aug 14, 2025 - MLB

Miami Marlins
4 :  9
Cleveland Guardians

Aug 13, 2025 - MLB

Miami Marlins
13 :  4
Cleveland Guardians

Aug 12, 2025 - MLB

Miami Marlins
3 :  4
Cleveland Guardians
W W W L W L
Victories

4/6 (67%)

Defeats

2/6 (33%)

Aug 19, 2025 - MLB

Cleveland Guardians
5 :  6
Arizona Diamondbacks

Aug 18, 2025 - MLB

Cleveland Guardians
3 :  1
Arizona Diamondbacks

Aug 10, 2025 - MLB

Cleveland Guardians
4 :  6
Chicago White Sox

Aug 9, 2025 - MLB

Cleveland Guardians
3 :  1
Chicago White Sox

Aug 8, 2025 - MLB

Cleveland Guardians
9 :  5
Chicago White Sox

Aug 6, 2025 - MLB

Cleveland Guardians
4 :  1
New York Mets
Arizona Diamondbacks
Arizona Diamondbacks Latest matches
W L L L L W
Victories

2/6 (33%)

Defeats

4/6 (67%)

Aug 19, 2025 - MLB

Cleveland Guardians
5 :  6
Arizona Diamondbacks

Aug 18, 2025 - MLB

Cleveland Guardians
3 :  1
Arizona Diamondbacks

Aug 17, 2025 - MLB

Arizona Diamondbacks
5 :  6
Colorado Rockies

Aug 16, 2025 - MLB

Arizona Diamondbacks
7 :  10
Colorado Rockies

Aug 15, 2025 - MLB

Arizona Diamondbacks
3 :  4
Colorado Rockies

Aug 14, 2025 - MLB

Arizona Diamondbacks
8 :  2
Colorado Rockies
L W W W L W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Aug 19, 2025 - MLB

Cleveland Guardians
5 :  6
Arizona Diamondbacks

Aug 18, 2025 - MLB

Cleveland Guardians
3 :  1
Arizona Diamondbacks

Aug 10, 2025 - MLB

Colorado Rockies
6 :  13
Arizona Diamondbacks

Aug 9, 2025 - MLB

Colorado Rockies
5 :  6
Arizona Diamondbacks

Aug 8, 2025 - MLB

Colorado Rockies
1 :  6
Arizona Diamondbacks

Aug 6, 2025 - MLB

San Diego Padres
3 :  2
Arizona Diamondbacks
W W W L L L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Aug 17, 2025 - MLB

Arizona Diamondbacks
5 :  6
Colorado Rockies

Aug 16, 2025 - MLB

Arizona Diamondbacks
7 :  10
Colorado Rockies

Aug 15, 2025 - MLB

Arizona Diamondbacks
3 :  4
Colorado Rockies

Aug 14, 2025 - MLB

Arizona Diamondbacks
8 :  2
Colorado Rockies

Aug 13, 2025 - MLB

Arizona Diamondbacks
6 :  4
Texas Rangers

Aug 12, 2025 - MLB

Arizona Diamondbacks
3 :  2
Texas Rangers

Cleveland Guardians against Arizona Diamondbacks : Head to Head (H2H)

Cleveland Guardians

67 %

Arizona Diamondbacks

33 %

Aug 19, 2025 - MLB

Cleveland Guardians
5 :  6
Arizona Diamondbacks

Aug 18, 2025 - MLB

Cleveland Guardians
3 :  1
Arizona Diamondbacks

Mar 25, 2025 - MLB Spring Training

Cleveland Guardians
3 :  2
Arizona Diamondbacks

Mar 24, 2025 - MLB Spring Training

Cleveland Guardians
4 :  3
Arizona Diamondbacks

Mar 6, 2025 - MLB Spring Training

Arizona Diamondbacks
0 :  4
Cleveland Guardians

Feb 24, 2025 - MLB Spring Training

Cleveland Guardians
3 :  4
Arizona Diamondbacks

Cleveland Guardians - Arizona Diamondbacks Key Points

  1. The Guardians are 4-11 in their last 15 matches against Arizona.
  2. The total runs went under in three of the last four Arizona vs Cleveland clashes.
  3. The total runs went under in four of the last six Arizona matches.
  4. The total went under in six of the last 10 Arizona matches at home.

Our Cleveland Guardians vs Arizona Diamondbacks Prediction

Bookmakers anticipate a close game with the Diamondbacks being the slight -136 betting favorites. On paper, the Guardians are the in-form side, winning 12 of their last 18 matches all-time. They also boast an impressive record of 6-2 in their previous eight games on the road. However, their recent record has been wanting, scoring an average of 2.6 runs per game in the last five matches. While at it, their pitchers allowed an average of 5.6 runs per contest. This could be their weakest link against the Diamondbacks, who have an average of 4.4 runs in the last five fixtures. We wouldn’t want to bet on Cleveland to cover the +1 run line here.

Our prediction for Arizona Diamondbacks vs Cleveland Guardians: Under 9 runs.

Prediction:

 

Under 9 runs.

-110
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Cleveland Guardians vs Arizona Diamondbacks Picks