Cleveland Cavaliers vs New York Knicks Prediction & Picks - NBA

USA - NBA

Cleveland Cavaliers
10/22/25 19:00
New York Knicks

Prediction:

 

Cleveland Cavaliers +2.5

-110
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 by Matt Lowrimore in NBA Picks

The NBA is finally back, and a full slate of games is scheduled for Wednesday night, including a matchup between the New York Knicks and the Cleveland Cavaliers. Let’s take a look at the match statistics and predictions for this game between the Knicks and the Cavaliers.

Cleveland enters this game having finished 64-18 last season and was first in the Eastern Conference. The Cavaliers advanced to the Eastern Conference Semifinals before losing to the Indiana Pacers in five games. Cleveland still has a strong lineup, led by Donovan Mitchell, who averaged 24.0 points per game last season. 

As for New York, they enter this game having finished 51-31 last season and were third in the Eastern Conference. The Knicks advanced to the Eastern Conference Finals before losing to the Indiana Pacers in six games. New York also still boasts a strong lineup, led by Jalen Brunson, who averaged 26.0 points per game last season.

Cleveland Cavaliers vs New York Knicks Form

Table

Teams % P W L
1
New York Knicks
New York Knicks
0 0 0 0
1
Cleveland Cavaliers
Cleveland Cavaliers
0 0 0 0

Cleveland Cavaliers and New York Knicks Latest Matches

Cleveland Cavaliers
Cleveland Cavaliers Latest matches
L L W W L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Jul 19, 2025 - NBA Summer League

Cleveland Cavaliers
71 :  82
Golden State Warriors

Jul 16, 2025 - NBA Summer League

Sacramento Kings
94 :  86
Cleveland Cavaliers

Jul 13, 2025 - NBA Summer League

Miami Heat
72 :  92
Cleveland Cavaliers

Jul 12, 2025 - NBA Summer League

Cleveland Cavaliers
93 :  83
Milwaukee Bucks

Jul 10, 2025 - NBA Summer League

Cleveland Cavaliers
115 :  116
Indiana Pacers

May 13, 2025 - NBA

Indiana Pacers
114 :  105
Cleveland Cavaliers
W L L L W L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Jul 16, 2025 - NBA Summer League

Sacramento Kings
94 :  86
Cleveland Cavaliers

Jul 13, 2025 - NBA Summer League

Miami Heat
72 :  92
Cleveland Cavaliers

May 13, 2025 - NBA

Indiana Pacers
114 :  105
Cleveland Cavaliers

May 6, 2025 - NBA

Indiana Pacers
120 :  119
Cleveland Cavaliers

May 4, 2025 - NBA

Indiana Pacers
121 :  112
Cleveland Cavaliers

Apr 23, 2025 - NBA

Miami Heat
112 :  121
Cleveland Cavaliers
W W L L W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Jul 19, 2025 - NBA Summer League

Cleveland Cavaliers
71 :  82
Golden State Warriors

Jul 12, 2025 - NBA Summer League

Cleveland Cavaliers
93 :  83
Milwaukee Bucks

Jul 10, 2025 - NBA Summer League

Cleveland Cavaliers
115 :  116
Indiana Pacers

May 11, 2025 - NBA

Cleveland Cavaliers
109 :  129
Indiana Pacers

May 9, 2025 - NBA

Cleveland Cavaliers
126 :  104
Indiana Pacers

Apr 28, 2025 - NBA

Cleveland Cavaliers
138 :  83
Miami Heat
New York Knicks
New York Knicks Latest matches
L L L W L L
Victories

1/6 (17%)

Defeats

5/6 (83%)

Jul 19, 2025 - NBA Summer League

Washington Wizards
94 :  85
New York Knicks

Jul 17, 2025 - NBA Summer League

Indiana Pacers
91 :  88
New York Knicks

Jul 15, 2025 - NBA Summer League

Brooklyn Nets
93 :  97
New York Knicks

Jul 13, 2025 - NBA Summer League

New York Knicks
81 :  94
Boston Celtics

Jul 11, 2025 - NBA Summer League

New York Knicks
86 :  104
Detroit Pistons

May 31, 2025 - NBA

New York Knicks
108 :  125
Indiana Pacers
L L W W L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Jul 19, 2025 - NBA Summer League

Washington Wizards
94 :  85
New York Knicks

Jul 17, 2025 - NBA Summer League

Indiana Pacers
91 :  88
New York Knicks

Jul 15, 2025 - NBA Summer League

Brooklyn Nets
93 :  97
New York Knicks

May 29, 2025 - NBA

Indiana Pacers
94 :  111
New York Knicks

May 23, 2025 - NBA

Indiana Pacers
114 :  109
New York Knicks

May 21, 2025 - NBA

Indiana Pacers
138 :  135
New York Knicks
L W L L L L
Victories

1/6 (17%)

Defeats

5/6 (83%)

Jul 13, 2025 - NBA Summer League

New York Knicks
81 :  94
Boston Celtics

Jul 11, 2025 - NBA Summer League

New York Knicks
86 :  104
Detroit Pistons

May 31, 2025 - NBA

New York Knicks
108 :  125
Indiana Pacers

May 27, 2025 - NBA

New York Knicks
121 :  130
Indiana Pacers

May 25, 2025 - NBA

New York Knicks
106 :  100
Indiana Pacers

May 14, 2025 - NBA

New York Knicks
102 :  127
Boston Celtics

Cleveland Cavaliers against New York Knicks : Head to Head (H2H)

Cleveland Cavaliers

83 %

New York Knicks

17 %

Apr 11, 2025 - NBA

Cleveland Cavaliers
108 :  102
New York Knicks

Apr 2, 2025 - NBA

New York Knicks
105 :  124
Cleveland Cavaliers

Feb 21, 2025 - NBA

New York Knicks
105 :  142
Cleveland Cavaliers

Oct 28, 2024 - NBA

Cleveland Cavaliers
110 :  104
New York Knicks

Mar 3, 2024 - NBA

New York Knicks
107 :  98
Cleveland Cavaliers

Nov 1, 2023 - NBA

Cleveland Cavaliers
95 :  89
New York Knicks

Cleveland Cavaliers - New York Knicks Key Points

  1. Cleveland’s Darius Garland is OUT
  2. Cleveland’s De’Andre Hunter is a Game-Time Decision
  3. New York’s Karl-Anthony Towns is a Game-Time Decision
  4. New York’s OG Anunoby is a Game-Time Decision

Our Cleveland Cavaliers vs New York Knicks Prediction

Cleveland is the short underdog in this game, but looks to be a solid betting option. The Cavaliers are dealing with some injuries to start the season, that being De’Andre Hunter and Darius Garland.

That said, New York is also dealing with some injuries, that being OG Anunoby and Karl-Anthony Towns, among a few others. 

The Cavaliers swept the Knicks in the regular season last year, winning these four games by an average margin of 17 points per game.

The start of a new season can always take time for teams to get up to speed; however, because the Cavs dominated the Knicks in their recent meetings, our New York Knicks vs Cleveland Cavaliers prediction is: Cleveland Cavaliers +2.5.

Prediction:

 

Cleveland Cavaliers +2.5

-110
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All tips are fully researched and given in good faith, but profits cannot be guaranteed.

Cleveland Cavaliers vs New York Knicks Picks