LSU Tigers vs Clemson Tigers Prediction & Picks - NCAA
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by Matt Lowrimore | in NCAA Picks
Plenty of Week 1 College Football games are scheduled for this weekend, one of which will include a highly anticipated matchup between the Clemson Tigers and the LSU Tigers. Let’s take a look at the match statistics and predictions for this game between Clemson and LSU.
LSU enters this game having finished the 2025-2026 season with a record of 7-6. This was a hugely disappointing season for the Tigers, who began last year as a top-10 team in the country. Further, it led to the decision to replace their head coach and hire Lane Kiffin from Ole Miss.
As for Clemson, they also enter this game having finished the 2025-206 season with a record of 7-6. Considering the Tigers began last season as a top-5 team in the country, their season was also a failure and one they will want to bounce back from, starting with LSU in this matchup.
It is also worth noting that these teams met last year in Week 1, with LSU winning by a score of 17-10, suggesting we could also see a low-scoring game this year as well.
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LSU Tigers vs Clemson Tigers Form
LSU Tigers and Clemson Tigers Latest Matches
2/6 (33%)
4/6 (67%)
Dec 27, 2025 - NCAA Division I, FBS, Playoffs
Nov 29, 2025 - NCAA
Nov 22, 2025 - NCAA
Nov 15, 2025 - NCAA
Nov 8, 2025 - NCAA
Oct 25, 2025 - NCAA
5/6 (83%)
1/6 (17%)
Nov 22, 2025 - NCAA
Nov 15, 2025 - NCAA
Oct 25, 2025 - NCAA
Oct 11, 2025 - NCAA
Sep 20, 2025 - NCAA
Sep 13, 2025 - NCAA
1/6 (17%)
5/6 (83%)
Dec 27, 2025 - NCAA Division I, FBS, Playoffs
Nov 29, 2025 - NCAA
Nov 8, 2025 - NCAA
Oct 18, 2025 - NCAA
Sep 27, 2025 - NCAA
Aug 30, 2025 - NCAA
4/6 (67%)
2/6 (33%)
Dec 27, 2025 - NCAA Division I, FBS, Playoffs
Nov 29, 2025 - NCAA
Nov 22, 2025 - NCAA
Nov 14, 2025 - NCAA
Nov 8, 2025 - NCAA
Nov 1, 2025 - NCAA
2/6 (33%)
4/6 (67%)
Dec 27, 2025 - NCAA Division I, FBS, Playoffs
Nov 22, 2025 - NCAA
Nov 8, 2025 - NCAA
Nov 1, 2025 - NCAA
Oct 18, 2025 - NCAA
Sep 20, 2025 - NCAA
4/6 (67%)
2/6 (33%)
Nov 29, 2025 - NCAA
Nov 14, 2025 - NCAA
Oct 11, 2025 - NCAA
Oct 4, 2025 - NCAA
Sep 13, 2025 - NCAA
Dec 21, 2024 - NCAA
LSU Tigers against Clemson Tigers : Head to Head (H2H)
100 %
0 %
Aug 30, 2025 - NCAA
LSU Tigers - Clemson Tigers Key Points
- Clemson averaged 27.2 points per game in 2025-2026
- Clemson allowed an average of 20.5 points per game in 2025-2026
- LSU averaged 22.8 points per game in 2025-2026
- LSU allowed 19.8 points per game in 2025-2026
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Our LSU Tigers vs Clemson Tigers Prediction
LSU is a double-digit favorite in this game; however, Clemson looks to be the best betting option. This goes directly to how inconsistent both teams were last season. Especially LSU, which only won two games by more than 10 points. Clemson, on the other hand, only lost two games by more than 10 points, showing they can be a competitive team even when the wins are not coming as often as they have in the past.
As previously mentioned, LSU beat Clemson by a score of 17-10 in Week 1 of the season last year. We expect a similar result in this matchup with LSU still adjusting to Lane Kiffin’s style of play.
Kiffin is known for having elite offenses, but Clemson’s defense still looks to be among the top units in the country. For that reason, our Clemson Tigers vs LSU Tigers prediction is: Clemson Tigers +10.5 Alternate Spread.
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All tips are fully researched and given in good faith, but profits cannot be guaranteed.
