Duke vs Clemson Prediction & Picks - NCAA Men

USA - NCAA Men

Duke
2/14/26 12:00
Clemson

Prediction:

 

Duke -12.5

-105
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 by Travis Pulver | in Basketball Picks

The Clemson Tigers (20-5, 10-2 ACC) will try to get back on the right side of the scoreboard Saturday afternoon when they take on the No. 4 Duke Blue Devils (22-2, 11-1 ACC) at Cameron Indoor Stadium in Durham, NC. This ACC clash between two ranked teams is scheduled to get underway at 12 p.m. EST on Saturday, February 14, with coverage provided by ESPN.

Clemson had been on a roll since losing back-to-back games earlier in the season to No. 12 Alabama and No. 10 BYU, going 13-1, 10-1 ACC before facing off against Virginia Tech on Wednesday. It was a game they never really had control of, as the Hokies led 40-33 at the half en route to a 76-66 victory, handing Clemson its second conference loss of the season. As for Duke, the Blue Devils got off to an 11-0 start before losing their first game of the season, 82-81, to No. 19 Texas Tech. They didn’t lose again until running into their arch-nemesis, North Carolina, last weekend (UNC won 71-68). The Blue Devils got back on track on Tuesday, beating Pittsburgh, 70-54.

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Duke vs Clemson Form

Table

Teams % P W L Series
2 Duke
0.935 31 29 2 8
45 Clemson
0.71 31 22 9 1

Duke and Clemson Latest Matches

Duke
Duke Latest matches
W W W W L
Victories

4/5 (80%)

Defeats

1/5 (20%)

Apr 5, 2025 - NCAA Basketball

Duke
67 :  70
Houston

Mar 27, 2025 - NCAA Basketball

Duke
100 :  93
Arizona

Mar 23, 2025 - NCAA Basketball

Duke
89 :  66
Baylor

Mar 21, 2025 - NCAA Basketball

Duke
93 :  49
Mount St. Marys Mountaineers

Mar 29, 2024 - NCAA Basketball

Houston
51 :  54
Duke
W W W L
Victories

3/4 (75%)

Defeats

1/4 (25%)

Apr 5, 2025 - NCAA Basketball

Duke
67 :  70
Houston

Mar 27, 2025 - NCAA Basketball

Duke
100 :  93
Arizona

Mar 23, 2025 - NCAA Basketball

Duke
89 :  66
Baylor

Mar 21, 2025 - NCAA Basketball

Duke
93 :  49
Mount St. Marys Mountaineers
W
Victories

1/1 (100%)

Defeats

0/1 (0%)

Mar 29, 2024 - NCAA Basketball

Houston
51 :  54
Duke
Clemson
Clemson Latest matches
W L L
Victories

1/3 (33%)

Defeats

2/3 (67%)

Mar 20, 2025 - NCAA Basketball

Clemson
67 :  69
McNeese State Cowboys

Mar 30, 2024 - NCAA Basketball

Alabama
89 :  82
Clemson

Mar 28, 2024 - NCAA Basketball

Arizona
72 :  77
Clemson
L
Victories

0/1 (0%)

Defeats

1/1 (100%)

Mar 20, 2025 - NCAA Basketball

Clemson
67 :  69
McNeese State Cowboys
W L
Victories

1/2 (50%)

Defeats

1/2 (50%)

Mar 30, 2024 - NCAA Basketball

Alabama
89 :  82
Clemson

Mar 28, 2024 - NCAA Basketball

Arizona
72 :  77
Clemson

Duke - Clemson Key Points

  1. Duke has dominated the all-time series 84-30, but Clemson won the last time these two teams met on Feb. 8, 2025, 77-71.
  2. Clemson has not won in Durham since the 1994-95 season.
  3. Duke is 7-7 ATS at home while Clemson is 8-2 ATS on the road.
  4. The OVER is 5-5 for Clemson on the road and 5-9 for Duke at home.
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Our Duke vs Clemson Prediction

I hesitate to take such a large spread against such a good team. But with Clemson’s dreadful history in Durham, it feels like the right choice. Duke has an incredible home court advantage at Cameron Indoor Stadium. Clemson has a solid squad and will likely keep it interesting heading into the second half, where the Blue Devils will pull away.

Our Clemson vs. Duke Pick: Duke -12.5

Prediction:

 

Duke -12.5

-105
$200 offered for betting!

All tips are fully researched and given in good faith, but profits cannot be guaranteed.

Duke vs Clemson Picks