Buffalo Bills vs Cincinnati Bengals Prediction & Picks - NFL

USA - NFL

Buffalo Bills
12/7/25 13:00
Cincinnati Bengals

Prediction:

 

The Bengals +5.5 points

-102
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 by Lou Aguila | in NFL Picks

The Buffalo Bills look to stay in the hunt for the AFC East title as they take on the Cincinnati Bengals on Sunday at Highmark Stadium.

The Bills are -5.5 point favorites against the Bengals, who snapped a four-game losing streak last week.

Current Form:

Buffalo improved to 8-4 after trouncing the Pittsburgh Steelers 26-7 last week. Quarterback Josh Allen threw for 123 yards with one touchdown and one interception, and running back James Cook ran for 144 yards on 33 carries. But it was the Bills’ suffocating defense that made the biggest difference in this match. Buffalo, which averages 21.6 points allowed per game this season, contained the Steelers to just 166 total yards and 7 points.

Cincinnati ended its four-game skid with a 32-14 win over the Baltimore Ravens last week. Joe Burrow made his triumphant return from injury as the Pro Bowl quarterback outdueled Ravens quarterback Lamar Jackson, throwing for 261 yards with two touchdowns. The Bengals' defense also showed up, forcing the Ravens to commit 5 turnovers in this match.

Buffalo Bills vs Cincinnati Bengals Form

Table

Teams Pts P W L
8
Buffalo Bills
Buffalo Bills
0.706 17 12 5
23
Cincinnati Bengals
Cincinnati Bengals
0.353 17 6 11

Buffalo Bills and Cincinnati Bengals Latest Matches

Buffalo Bills
Buffalo Bills Latest matches
W W L W L W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Nov 30, 2025 - NFL

Pittsburgh Steelers
7 :  26
Buffalo Bills

Nov 20, 2025 - NFL

Houston Texans
23 :  19
Buffalo Bills

Nov 16, 2025 - NFL

Buffalo Bills
44 :  32
Tampa Bay Buccaneers

Nov 9, 2025 - NFL

Miami Dolphins
30 :  13
Buffalo Bills

Nov 2, 2025 - NFL

Buffalo Bills
28 :  21
Kansas City Chiefs

Oct 26, 2025 - NFL

Carolina Panthers
9 :  40
Buffalo Bills
W W W L W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Nov 16, 2025 - NFL

Buffalo Bills
44 :  32
Tampa Bay Buccaneers

Nov 2, 2025 - NFL

Buffalo Bills
28 :  21
Kansas City Chiefs

Oct 5, 2025 - NFL

Buffalo Bills
20 :  23
New England Patriots

Sep 28, 2025 - NFL

Buffalo Bills
31 :  19
New Orleans Saints

Sep 18, 2025 - NFL

Buffalo Bills
31 :  21
Miami Dolphins

Sep 7, 2025 - NFL

Buffalo Bills
41 :  40
Baltimore Ravens
W L W L L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Nov 30, 2025 - NFL

Pittsburgh Steelers
7 :  26
Buffalo Bills

Nov 20, 2025 - NFL

Houston Texans
23 :  19
Buffalo Bills

Nov 9, 2025 - NFL

Miami Dolphins
30 :  13
Buffalo Bills

Oct 26, 2025 - NFL

Carolina Panthers
9 :  40
Buffalo Bills

Oct 13, 2025 - NFL

Atlanta Falcons
24 :  14
Buffalo Bills

Sep 14, 2025 - NFL

New York Jets
10 :  30
Buffalo Bills
Cincinnati Bengals
Cincinnati Bengals Latest matches
W L L L L W
Victories

2/6 (33%)

Defeats

4/6 (67%)

Nov 27, 2025 - NFL

Baltimore Ravens
14 :  32
Cincinnati Bengals

Nov 23, 2025 - NFL

Cincinnati Bengals
20 :  26
New England Patriots

Nov 16, 2025 - NFL

Pittsburgh Steelers
34 :  12
Cincinnati Bengals

Nov 2, 2025 - NFL

Cincinnati Bengals
42 :  47
Chicago Bears

Oct 26, 2025 - NFL

Cincinnati Bengals
38 :  39
New York Jets

Oct 16, 2025 - NFL

Cincinnati Bengals
33 :  31
Pittsburgh Steelers
W L W L L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Nov 23, 2025 - NFL

Cincinnati Bengals
20 :  26
New England Patriots

Nov 2, 2025 - NFL

Cincinnati Bengals
42 :  47
Chicago Bears

Oct 26, 2025 - NFL

Cincinnati Bengals
38 :  39
New York Jets

Oct 16, 2025 - NFL

Cincinnati Bengals
33 :  31
Pittsburgh Steelers

Oct 5, 2025 - NFL

Cincinnati Bengals
24 :  37
Detroit Lions

Sep 14, 2025 - NFL

Cincinnati Bengals
31 :  27
Jacksonville Jaguars
W L L L L W
Victories

2/6 (33%)

Defeats

4/6 (67%)

Nov 27, 2025 - NFL

Baltimore Ravens
14 :  32
Cincinnati Bengals

Nov 16, 2025 - NFL

Pittsburgh Steelers
34 :  12
Cincinnati Bengals

Oct 12, 2025 - NFL

Green Bay Packers
27 :  18
Cincinnati Bengals

Sep 29, 2025 - NFL

Denver Broncos
28 :  3
Cincinnati Bengals

Sep 21, 2025 - NFL

Minnesota Vikings
48 :  10
Cincinnati Bengals

Sep 7, 2025 - NFL

Cleveland Browns
16 :  17
Cincinnati Bengals

Buffalo Bills against Cincinnati Bengals : Head to Head (H2H)

Buffalo Bills

0 %

Cincinnati Bengals

100 %

Nov 5, 2023 - NFL

Cincinnati Bengals
24 :  18
Buffalo Bills

Jan 22, 2023 - NFL

Buffalo Bills
10 :  27
Cincinnati Bengals

Buffalo Bills - Cincinnati Bengals Key Points

  1. Buffalo is 4-2 ATS in its last 6 games.
  2. Buffalo is 13-6 SU in its last 19 games.
  3. Cincinnati is 5-1 ATS in its last 6 games against Buffalo.
  4. Cincinnati is 6-2 SU in its last 8 games against Buffalo.

Our Buffalo Bills vs Cincinnati Bengals Prediction

Fearless Forecast: I am taking the Bengals to cover the spread at +5.0 points. Joe Burrow’s fantastic return gives me confidence that Cincinnati will be a far tougher matchup for any team throughout the remainder of the season. Burrow is the engine of the Bengals' offense, and it showed right away with their win over the Ravens. As for the Bills, they are 15-1 in their last 16 home games and 4-2 ATS in their last 6 games. It would be intriguing to see how the Bills’ D will be able to shut down the Bengals now that they have their starting quarterback back. I believe Burrow will dazzle anew, giving the Bengals a shot at winning this match down the stretch.

Our betting prediction for the Cincinnati Bengals vs. the Buffalo Bills: The Bengals +5.5 points

Prediction:

 

The Bengals +5.5 points

-102
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Buffalo Bills vs Cincinnati Bengals Picks