Chicago White Sox vs New York Yankees Prediction & Picks - MLB

Prediction published on 9/25/25, 3:22 PM  by Lou Aguila | Modified on 9/29/25 at 5:09 AM in MLB Picks

The New York Yankees will host the Chicago White Sox anew in the second game of their series on Thursday at Yankee Stadium.

The Yankees, 7-1 in their last 8 games and 6-0 in their last six meetings against the White Sox, are listed at -300 moneyline and -137 on a -1.5 runline.

Current Form:

With only a handful of games left on their schedule, the Yankees (90-88) are still battling the Toronto Blue Jays (90-68) for the No.1 spot in the AL East. New York, which is 14-7 this September, can overtake the Blue Jays if it wins Game 2 against the White Sox and Toronto loses another game against the Red Sox on Thursday. Over their last five games, the Yankees have pitched to a 1.40 ERA and averaged 5.4 runs per game.

The White Sox have lost their last four games. They opened the week with back-to-back losses to World Series contenders, the San Diego Padres, before dropping two more games against last year’s World Series runner-up, the Yankees. Chicago has performed miserably on the mound and at the plate in their last five games, during which they have batted .190 with 2.5 runs per game and posted a 5.09 ERA.