Chicago White Sox vs New York Yankees Prediction & Picks - MLB

USA - MLB

Chicago White Sox
9/24/25 19:05
New York Yankees

Prediction:

 

Total Under 7.0 Runs

-102
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 by Lou Aguila in MLB Picks

The New York Yankees aim to extend their winning streak to four games as they take on the Chicago White Sox in Game 2 of their series at Yankee Stadium.

The Yankees, who have received 72 percent of the bets, are heavy moneyline favorites at -375 and -166 on the -1.5 run line. The total is over/under 8.0 runs, which offers more intrigue since the total has gone OVER in three of the Yankees’ last 10 games.

Current Form:

The Yankees have won their last three games, including a close 3-2 win over the White Sox in the series opener. New York, 7-3 in their last 10 games, is within one game of the Toronto Blue Jays, who still hold the No.1 spot in the AL East with an 89-68 record.

New York has averaged 5.0 runs per game on a .251 BA over the last five games. During this stretch, the Yankees have posted an elite 1.20 ERA, and the bullpen finally made an impact with a 0.63 ERA over the last five games.

The White Sox have dropped their last three games and nine of their last 10. Chicago owns the worst record in the American League at 58-99 and the second-worst record in the MLB behind the 43-114 Colorado Rockies.

Chicago has pitched a solid 3.98 ERA in the last five games. However, they have only batted .188 at the plate, averaging 2.5 runs per game in this five-game spell.

Chicago White Sox vs New York Yankees Form

Table

Teams % P W L
4
New York Yankees
New York Yankees
0.567 157 89 68
29
Chicago White Sox
Chicago White Sox
0.369 157 58 99

Chicago White Sox and New York Yankees Latest Matches

Chicago White Sox
Chicago White Sox Latest matches
L L W L L L
Victories

1/6 (17%)

Defeats

5/6 (83%)

Sep 23, 2025 - MLB

Chicago White Sox
2 :  3
New York Yankees

Sep 21, 2025 - MLB

San Diego Padres
3 :  2
Chicago White Sox

Sep 20, 2025 - MLB

San Diego Padres
7 :  3
Chicago White Sox

Sep 19, 2025 - MLB

San Diego Padres
3 :  4
Chicago White Sox

Sep 17, 2025 - MLB

Baltimore Orioles
3 :  1
Chicago White Sox

Sep 16, 2025 - MLB

Baltimore Orioles
8 :  7
Chicago White Sox
L L L W L L
Victories

1/6 (17%)

Defeats

5/6 (83%)

Sep 21, 2025 - MLB

San Diego Padres
3 :  2
Chicago White Sox

Sep 20, 2025 - MLB

San Diego Padres
7 :  3
Chicago White Sox

Sep 19, 2025 - MLB

San Diego Padres
3 :  4
Chicago White Sox

Sep 17, 2025 - MLB

Baltimore Orioles
3 :  1
Chicago White Sox

Sep 16, 2025 - MLB

Baltimore Orioles
8 :  7
Chicago White Sox

Sep 15, 2025 - MLB

Baltimore Orioles
4 :  1
Chicago White Sox
L W L L L L
Victories

1/6 (17%)

Defeats

5/6 (83%)

Sep 23, 2025 - MLB

Chicago White Sox
2 :  3
New York Yankees

Sep 14, 2025 - MLB

Chicago White Sox
2 :  3
Cleveland Guardians

Sep 13, 2025 - MLB

Chicago White Sox
1 :  3
Cleveland Guardians

Sep 12, 2025 - MLB

Chicago White Sox
0 :  4
Cleveland Guardians

Sep 7, 2025 - MLB

Chicago White Sox
6 :  4
Detroit Tigers

Sep 6, 2025 - MLB

Chicago White Sox
0 :  6
Detroit Tigers
New York Yankees
New York Yankees Latest matches
W W L W W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Sep 23, 2025 - MLB

Chicago White Sox
2 :  3
New York Yankees

Sep 21, 2025 - MLB

New York Yankees
7 :  1
Baltimore Orioles

Sep 20, 2025 - MLB

New York Yankees
6 :  1
Baltimore Orioles

Sep 19, 2025 - MLB

New York Yankees
2 :  4
Baltimore Orioles

Sep 18, 2025 - MLB

New York Yankees
7 :  0
Baltimore Orioles

Sep 17, 2025 - MLB

New York Yankees
10 :  5
Minnesota Twins
W W L L W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Sep 23, 2025 - MLB

Chicago White Sox
2 :  3
New York Yankees

Sep 11, 2025 - MLB

Detroit Tigers
3 :  9
New York Yankees

Sep 10, 2025 - MLB

Detroit Tigers
11 :  1
New York Yankees

Sep 9, 2025 - MLB

Detroit Tigers
12 :  2
New York Yankees

Sep 7, 2025 - MLB

Toronto Blue Jays
3 :  4
New York Yankees

Sep 6, 2025 - MLB

Toronto Blue Jays
1 :  3
New York Yankees
W W W L W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Sep 21, 2025 - MLB

New York Yankees
7 :  1
Baltimore Orioles

Sep 20, 2025 - MLB

New York Yankees
6 :  1
Baltimore Orioles

Sep 19, 2025 - MLB

New York Yankees
2 :  4
Baltimore Orioles

Sep 18, 2025 - MLB

New York Yankees
7 :  0
Baltimore Orioles

Sep 17, 2025 - MLB

New York Yankees
10 :  5
Minnesota Twins

Sep 16, 2025 - MLB

New York Yankees
10 :  9
Minnesota Twins

Chicago White Sox against New York Yankees : Head to Head (H2H)

Chicago White Sox

17 %

New York Yankees

83 %

Sep 23, 2025 - MLB

Chicago White Sox
2 :  3
New York Yankees

Aug 31, 2025 - MLB

New York Yankees
2 :  3
Chicago White Sox

Aug 30, 2025 - MLB

New York Yankees
5 :  3
Chicago White Sox

Aug 29, 2025 - MLB

New York Yankees
10 :  2
Chicago White Sox

Aug 28, 2025 - MLB

New York Yankees
10 :  4
Chicago White Sox

Aug 14, 2024 - MLB

New York Yankees
10 :  2
Chicago White Sox

Chicago White Sox - New York Yankees Key Points

  1. The total has gone UNDER in 9 of Chicago White Sox's last 11 games.
  2. The total has gone UNDER in 5 of Chicago White Sox's last 6 games on the road.
  3. The total has gone UNDER in 5 of NY Yankees' last 5 games.
  4. The total has gone UNDER in 5 of NY Yankees' last 6 games against an opponent in the American League.

Our Chicago White Sox vs New York Yankees Prediction

The Yankees are a no-brainer pick to win outright and cover the spread, having received over 70 percent of the bets, according to Covers.com. As for the total, the Under (-102) might be an intriguing pick as these two teams have only combined for an average of 6.0 runs per game in their last three meetings. Max Fried, who has carried a 1.89 ERA over his last five starts, is scheduled to face the White Sox for the first time in six year. The last time he pitched against Chicago, Fried allowed three earned runs and recorded 11 strikeouts to power his former team, the Atlanta Braves, to a 10-7 win over the White Sox on August 30, 2019. Relief pitcher Fraser Ellard will start for Chicago, who surrendered zero earned runs in two short mound appearances.

The White Sox’s pitching numbers over the last five games (3.98 ERA) might be good enough to hold the Yankees under five runs in this game, but their listless offense, which generates 2.5 runs per game in the last five games, makes it difficult for them to score an upset against the Yankees.

Fearless Forecast: Yankees 4, White Sox 0

Our fearless forecast for the New York Yankees vs. the Chicago White Sox: Total Under 8.0 Runs

Prediction:

 

Total Under 7.0 Runs

-102
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Chicago White Sox vs New York Yankees Picks