Chicago White Sox vs Cleveland Guardians Prediction & Picks - MLB

USA - MLB

Chicago White Sox
4/9/25 18:10
Cleveland Guardians

Prediction:

 

Over 7.5 runs.

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 by Carlos Zabala in MLB Picks

For the White Sox, who lost 121 games in 2024, the start of 2025 is already off to a discouraging start. Their record through the first 10 games of the new season is 2-8, and even Smith's no-hitter until the sixth inning didn't help, as the White Sox offense also had a poor night, allowing just three hits.

Finally, Clevinger, out of control, couldn't hold a scoreless run in the bottom of the ninth, and the Guardians took the first game of the series against the White Sox with a bases-loaded walk that resulted in a walk-off. This was the first time a 1-0 game has been resolved this way in MLB since 2009.

For the Guardians, Santana's hit reached 1.800, and Clase once again showed his prowess as a reliever, holding a scoreless run in the ninth inning, with Luis Robert left on third after reaching base on an error. The dominant closer earned his second win of the season.

The White Sox starter in Game 2 will be Sean Burke, who had a solid Opening Day in Chicago, pitching six innings without allowing an ER, but then struggled at Target Field against the Twins, allowing six ERs in 4.1 IP.

Chicago White Sox vs Cleveland Guardians Form

Table

Teams % P W L
10
Cleveland Guardians
Cleveland Guardians
0.543 162 88 74
29
Chicago White Sox
Chicago White Sox
0.37 162 60 102

Chicago White Sox and Cleveland Guardians Latest Matches

Chicago White Sox
Chicago White Sox Latest matches
L L L L L L
Victories

0/6 (0%)

Defeats

6/6 (100%)

Apr 8, 2025 - MLB

Chicago White Sox
0 :  1
Cleveland Guardians

Apr 6, 2025 - MLB

Chicago White Sox
3 :  4
Detroit Tigers

Apr 5, 2025 - MLB

Chicago White Sox
2 :  7
Detroit Tigers

Apr 4, 2025 - MLB

Chicago White Sox
4 :  7
Detroit Tigers

Apr 2, 2025 - MLB

Minnesota Twins
6 :  1
Chicago White Sox

Apr 1, 2025 - MLB

Minnesota Twins
8 :  3
Chicago White Sox
W L L W L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Apr 2, 2025 - MLB

Minnesota Twins
6 :  1
Chicago White Sox

Apr 1, 2025 - MLB

Minnesota Twins
8 :  3
Chicago White Sox

Mar 31, 2025 - MLB

Minnesota Twins
0 :  9
Chicago White Sox

Mar 30, 2025 - MLB

Los Angeles Angels
3 :  2
Chicago White Sox

Mar 29, 2025 - MLB

Los Angeles Angels
1 :  0
Chicago White Sox

Mar 27, 2025 - MLB

Los Angeles Angels
1 :  8
Chicago White Sox
W L L L L L
Victories

1/6 (17%)

Defeats

5/6 (83%)

Apr 8, 2025 - MLB

Chicago White Sox
0 :  1
Cleveland Guardians

Apr 6, 2025 - MLB

Chicago White Sox
3 :  4
Detroit Tigers

Apr 5, 2025 - MLB

Chicago White Sox
2 :  7
Detroit Tigers

Apr 4, 2025 - MLB

Chicago White Sox
4 :  7
Detroit Tigers

Mar 22, 2025 - MLB Spring Training

Chicago White Sox
4 :  10
Colorado Rockies

Mar 21, 2025 - MLB Spring Training

Chicago White Sox
8 :  5
Cincinnati Reds
Cleveland Guardians
Cleveland Guardians Latest matches
L L W L L W
Victories

2/6 (33%)

Defeats

4/6 (67%)

Apr 8, 2025 - MLB

Chicago White Sox
0 :  1
Cleveland Guardians

Apr 6, 2025 - MLB

Cleveland Guardians
2 :  6
Los Angeles Angels

Apr 5, 2025 - MLB

Cleveland Guardians
4 :  10
Los Angeles Angels

Apr 4, 2025 - MLB

Cleveland Guardians
8 :  6
Los Angeles Angels

Apr 2, 2025 - MLB

Cleveland Guardians
2 :  5
San Diego Padres

Apr 1, 2025 - MLB

Cleveland Guardians
0 :  7
San Diego Padres
L W W L W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Apr 8, 2025 - MLB

Chicago White Sox
0 :  1
Cleveland Guardians

Mar 22, 2025 - MLB Spring Training

San Diego Padres
8 :  12
Cleveland Guardians

Mar 19, 2025 - MLB Spring Training

Athletics
8 :  3
Cleveland Guardians

Mar 17, 2025 - MLB Spring Training

Cincinnati Reds
0 :  3
Cleveland Guardians

Mar 14, 2025 - MLB Spring Training

Seattle Mariners
7 :  8
Cleveland Guardians

Mar 12, 2025 - MLB Spring Training

San Francisco Giants
11 :  2
Cleveland Guardians
L L L W L L
Victories

1/6 (17%)

Defeats

5/6 (83%)

Apr 6, 2025 - MLB

Cleveland Guardians
2 :  6
Los Angeles Angels

Apr 5, 2025 - MLB

Cleveland Guardians
4 :  10
Los Angeles Angels

Apr 4, 2025 - MLB

Cleveland Guardians
8 :  6
Los Angeles Angels

Apr 2, 2025 - MLB

Cleveland Guardians
2 :  5
San Diego Padres

Apr 1, 2025 - MLB

Cleveland Guardians
0 :  7
San Diego Padres

Mar 31, 2025 - MLB

Cleveland Guardians
2 :  7
San Diego Padres

Chicago White Sox against Cleveland Guardians : Head to Head (H2H)

Chicago White Sox

33 %

Cleveland Guardians

67 %

Apr 8, 2025 - MLB

Chicago White Sox
0 :  1
Cleveland Guardians

Mar 9, 2025 - MLB Spring Training

Chicago White Sox
0 :  1
Cleveland Guardians

Feb 27, 2025 - MLB Spring Training

Cleveland Guardians
2 :  4
Chicago White Sox

Sep 9, 2024 - MLB

Cleveland Guardians
5 :  3
Chicago White Sox

Jul 4, 2024 - MLB

Chicago White Sox
4 :  8
Cleveland Guardians

Jul 3, 2024 - MLB

Chicago White Sox
8 :  2
Cleveland Guardians

Chicago White Sox - Cleveland Guardians Key Points

  1. Burke hasn't thrown any walks this season
  2. 53-33 was the Guardians' record in Cleveland in 2024
  3. White Sox have only recorded 5 stolen bases this season
  4. The Guardians have won 7 of their last 8 games against the White Sox

Our Chicago White Sox vs Cleveland Guardians Prediction

Logan Allen struggled severely with his run in his season debut, recording 5 BBs against the Padres at Petco Park, along with 7 hits and 4 earned runs in a game the Guardians lost 0-7. It would be unusual for the Guardians' lineup to string together two games with fewer than 5 hits in a row, but Allen's run in the game isn't a guarantee either. It might be best to aim for a high-run game on Wednesday. Our prediction for Guardians vs White Sox is: Over 7.5 runs.

Prediction:

 

Over 7.5 runs.

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Chicago White Sox vs Cleveland Guardians Picks