Chicago Cubs vs San Francisco Giants Prediction & Picks - MLB

USA - MLB

Chicago Cubs
8/28/25 15:45
San Francisco Giants

Prediction:

 

The Giants will win

-109
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 by Lou Aguila in MLB Picks

The San Francisco Giants are expected to march into Thursday’s series finale with the Chicago Cubs as slight -108 home underdogs despite topping the visiting team in the first two games at Oracle Park.

The Giants are making their final push towards postseason qualification with barely four weeks left in the regular season. San Francisco is still three games below .500 at 65-68, but they are just seven games off the current holder of the No.3 wildcard spot in the National League, the 72-61 New York Mets. The Giants have put up strong numbers on both ends in their last five games, pitching a 2.82 ERA and averaging 6.7 runs per game.

Meanwhile, the Cubs’ pitching might have hardly been felt by the Giants in the first two games of this series. Chicago, boasting a 3.84 ERA in the season, surrendered five runs in Game 1 before squandering 12 runs in Game 2. The Cubs’ offensive firepower has noticeably diminished in the series, scoring a total of five runs after two games.

Chicago Cubs vs San Francisco Giants Form

Table

Teams % P W L
5
Chicago Cubs
Chicago Cubs
0.57 135 77 58
17
San Francisco Giants
San Francisco Giants
0.496 135 67 68

Chicago Cubs and San Francisco Giants Latest Matches

Chicago Cubs
Chicago Cubs Latest matches
L W W W L L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Aug 27, 2025 - MLB

Chicago Cubs
3 :  12
San Francisco Giants

Aug 26, 2025 - MLB

Chicago Cubs
2 :  5
San Francisco Giants

Aug 24, 2025 - MLB

Chicago Cubs
4 :  3
Los Angeles Angels

Aug 23, 2025 - MLB

Chicago Cubs
12 :  1
Los Angeles Angels

Aug 22, 2025 - MLB

Chicago Cubs
3 :  2
Los Angeles Angels

Aug 21, 2025 - MLB

Milwaukee Brewers
4 :  1
Chicago Cubs
W L W W W L
Victories

4/6 (67%)

Defeats

2/6 (33%)

Aug 21, 2025 - MLB

Milwaukee Brewers
4 :  1
Chicago Cubs

Aug 20, 2025 - MLB

Milwaukee Brewers
3 :  4
Chicago Cubs

Aug 19, 2025 - MLB

Milwaukee Brewers
1 :  4
Chicago Cubs

Aug 19, 2025 - MLB

Milwaukee Brewers
4 :  6
Chicago Cubs

Aug 18, 2025 - MLB

Milwaukee Brewers
7 :  0
Chicago Cubs

Aug 17, 2025 - MLB

Pittsburgh Pirates
3 :  4
Chicago Cubs
L W W W L L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Aug 27, 2025 - MLB

Chicago Cubs
3 :  12
San Francisco Giants

Aug 26, 2025 - MLB

Chicago Cubs
2 :  5
San Francisco Giants

Aug 24, 2025 - MLB

Chicago Cubs
4 :  3
Los Angeles Angels

Aug 23, 2025 - MLB

Chicago Cubs
12 :  1
Los Angeles Angels

Aug 22, 2025 - MLB

Chicago Cubs
3 :  2
Los Angeles Angels

Aug 14, 2025 - MLB

Chicago Cubs
1 :  2
Toronto Blue Jays
San Francisco Giants
San Francisco Giants Latest matches
L W L W W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Aug 27, 2025 - MLB

Chicago Cubs
3 :  12
San Francisco Giants

Aug 26, 2025 - MLB

Chicago Cubs
2 :  5
San Francisco Giants

Aug 24, 2025 - MLB

San Francisco Giants
4 :  3
Milwaukee Brewers

Aug 23, 2025 - MLB

San Francisco Giants
7 :  1
Milwaukee Brewers

Aug 22, 2025 - MLB

San Francisco Giants
4 :  5
Milwaukee Brewers

Aug 21, 2025 - MLB

San Francisco Giants
4 :  8
San Diego Padres
L L L W W W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Aug 27, 2025 - MLB

Chicago Cubs
3 :  12
San Francisco Giants

Aug 26, 2025 - MLB

Chicago Cubs
2 :  5
San Francisco Giants

Aug 17, 2025 - MLB

Tampa Bay Rays
1 :  7
San Francisco Giants

Aug 16, 2025 - MLB

Tampa Bay Rays
2 :  1
San Francisco Giants

Aug 15, 2025 - MLB

Tampa Bay Rays
7 :  6
San Francisco Giants

Aug 13, 2025 - MLB

San Diego Padres
11 :  1
San Francisco Giants
L L L L W W
Victories

2/6 (33%)

Defeats

4/6 (67%)

Aug 24, 2025 - MLB

San Francisco Giants
4 :  3
Milwaukee Brewers

Aug 23, 2025 - MLB

San Francisco Giants
7 :  1
Milwaukee Brewers

Aug 22, 2025 - MLB

San Francisco Giants
4 :  5
Milwaukee Brewers

Aug 21, 2025 - MLB

San Francisco Giants
4 :  8
San Diego Padres

Aug 20, 2025 - MLB

San Francisco Giants
1 :  8
San Diego Padres

Aug 19, 2025 - MLB

San Francisco Giants
1 :  5
San Diego Padres

Chicago Cubs against San Francisco Giants : Head to Head (H2H)

Chicago Cubs

17 %

San Francisco Giants

83 %

Aug 27, 2025 - MLB

Chicago Cubs
3 :  12
San Francisco Giants

Aug 26, 2025 - MLB

Chicago Cubs
2 :  5
San Francisco Giants

May 7, 2025 - MLB

San Francisco Giants
3 :  1
Chicago Cubs

May 6, 2025 - MLB

San Francisco Giants
14 :  5
Chicago Cubs

May 5, 2025 - MLB

San Francisco Giants
2 :  9
Chicago Cubs

Mar 9, 2025 - MLB Spring Training

San Francisco Giants
8 :  6
Chicago Cubs

Chicago Cubs - San Francisco Giants Key Points

  1. Chicago Cubs is 1-4 SU in its last 5 games against San Francisco.
  2. Chicago Cubs is 1-6 SU in its last 7 games when playing on the road against San Francisco.
  3. San Francisco is 4-1 SU in its last 5 games.
  4. San Francisco is 6-1 SU in its last 7 games when playing at home against Chicago Cubs.

Our Chicago Cubs vs San Francisco Giants Prediction

San Francisco is 6-1 SU in its last 7 games when playing at home against the Chicago Cubs and 4-1 SU in its last 5 games. The Giants will be sending one of their best arms in Logan Webb to the bump on Thursday. Webb is 3-2 with a 2.03 ERA in his last five starts and has recently limited the best offensive team in the National League to one earned run over six innings in a 7-1 win on August 23.

The Chicago Cubs are 1-6 SU in their last 7 games when playing on the road against San Francisco. They are also 1-4 SU in their last five games vs. the Giants. Although Shota Imanaga has maintained a solid 2.81 ERA over his last five starts, Chicago’s 0-4 record against the Giants in their last four games makes it difficult for me to go all-in on them in this very crucial ballgame for both squads.

Our betting prediction for the Chicago Cubs vs. the San Francisco Giants: the Giants will win.

Prediction:

 

The Giants will win

-109
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Chicago Cubs vs San Francisco Giants Picks