Chicago Cubs vs Pittsburgh Pirates Prediction & Picks - MLB

USA - MLB

Chicago Cubs
9/17/25 12:35
Pittsburgh Pirates

Prediction:

 

The Cubs -1.5 Runs

+104
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 by Lou Aguila in MLB Picks

The Chicago Cubs will go for nothing less than a sweep in Wednesday’s series finale against the Pittsburgh Pirates at PNC Park.

The Cubs, 8-2 in their last 10 games against the Pirates, have received 62 percent of bets to win again (-167 moneyline) in Game 3, according to Covers.com.

Current Form:

The Cubs (87-64) may have already locked up their spot in the wild card series after winning four of their last five games. In this stretch, Chicago has outpitched the competition, sporting a 2.60 ERA and 1.05 WHIP. The offense has remained decent, averaging almost five runs a game (4.6 runs per game) on a .298 batting average.

The Pirates (65-87) have lost four of their last five games and 10 of their last 11 games. Pittsburgh has maintained a competitive 3.82 ERA over a 10-game stretch, a testament to its much-touted pitching prowess. Unfortunately, their lackluster offense continues to be a major problem for the Pirates, who would have achieved contender status had they produced more runs per game this season. The Pirates have only averaged 2.1 runs per game while batting .168 over the last 10 games.

Chicago Cubs vs Pittsburgh Pirates Form

Table

Teams % P W L
4
Chicago Cubs
Chicago Cubs
0.576 151 87 64
27
Pittsburgh Pirates
Pittsburgh Pirates
0.428 152 65 87

Chicago Cubs and Pittsburgh Pirates Latest Matches

Chicago Cubs
Chicago Cubs Latest matches
W W L W W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Sep 16, 2025 - MLB

Chicago Cubs
4 :  1
Pittsburgh Pirates

Sep 15, 2025 - MLB

Chicago Cubs
4 :  0
Pittsburgh Pirates

Sep 14, 2025 - MLB

Tampa Bay Rays
3 :  4
Chicago Cubs

Sep 13, 2025 - MLB

Tampa Bay Rays
5 :  4
Chicago Cubs

Sep 12, 2025 - MLB

Tampa Bay Rays
4 :  6
Chicago Cubs

Sep 10, 2025 - MLB

Chicago Cubs
3 :  2
Atlanta Braves
W L L W L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Sep 14, 2025 - MLB

Tampa Bay Rays
3 :  4
Chicago Cubs

Sep 13, 2025 - MLB

Tampa Bay Rays
5 :  4
Chicago Cubs

Sep 12, 2025 - MLB

Tampa Bay Rays
4 :  6
Chicago Cubs

Sep 7, 2025 - MLB

Washington Nationals
6 :  3
Chicago Cubs

Sep 6, 2025 - MLB

Washington Nationals
2 :  1
Chicago Cubs

Sep 5, 2025 - MLB

Washington Nationals
5 :  11
Chicago Cubs
W L W W W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Sep 16, 2025 - MLB

Chicago Cubs
4 :  1
Pittsburgh Pirates

Sep 15, 2025 - MLB

Chicago Cubs
4 :  0
Pittsburgh Pirates

Sep 10, 2025 - MLB

Chicago Cubs
3 :  2
Atlanta Braves

Sep 9, 2025 - MLB

Chicago Cubs
6 :  1
Atlanta Braves

Sep 8, 2025 - MLB

Chicago Cubs
1 :  4
Atlanta Braves

Aug 31, 2025 - MLB

Chicago Cubs
5 :  6
Colorado Rockies
Pittsburgh Pirates
Pittsburgh Pirates Latest matches
L L W L L L
Victories

1/6 (17%)

Defeats

5/6 (83%)

Sep 16, 2025 - MLB

Chicago Cubs
4 :  1
Pittsburgh Pirates

Sep 15, 2025 - MLB

Chicago Cubs
4 :  0
Pittsburgh Pirates

Sep 14, 2025 - MLB

Pittsburgh Pirates
3 :  4
Washington Nationals

Sep 13, 2025 - MLB

Pittsburgh Pirates
5 :  1
Washington Nationals

Sep 12, 2025 - MLB

Pittsburgh Pirates
5 :  6
Washington Nationals

Sep 11, 2025 - MLB

Pittsburgh Pirates
2 :  3
Baltimore Orioles
W L L L L L
Victories

1/6 (17%)

Defeats

5/6 (83%)

Sep 16, 2025 - MLB

Chicago Cubs
4 :  1
Pittsburgh Pirates

Sep 15, 2025 - MLB

Chicago Cubs
4 :  0
Pittsburgh Pirates

Sep 7, 2025 - MLB

Milwaukee Brewers
10 :  2
Pittsburgh Pirates

Sep 6, 2025 - MLB

Milwaukee Brewers
4 :  1
Pittsburgh Pirates

Sep 5, 2025 - MLB

Milwaukee Brewers
5 :  2
Pittsburgh Pirates

Sep 4, 2025 - MLB

Los Angeles Dodgers
3 :  5
Pittsburgh Pirates
L L L L W L
Victories

1/6 (17%)

Defeats

5/6 (83%)

Sep 14, 2025 - MLB

Pittsburgh Pirates
3 :  4
Washington Nationals

Sep 13, 2025 - MLB

Pittsburgh Pirates
5 :  1
Washington Nationals

Sep 12, 2025 - MLB

Pittsburgh Pirates
5 :  6
Washington Nationals

Sep 11, 2025 - MLB

Pittsburgh Pirates
2 :  3
Baltimore Orioles

Sep 10, 2025 - MLB

Pittsburgh Pirates
1 :  2
Baltimore Orioles

Sep 9, 2025 - MLB

Pittsburgh Pirates
2 :  3
Baltimore Orioles

Chicago Cubs against Pittsburgh Pirates : Head to Head (H2H)

Chicago Cubs

83 %

Pittsburgh Pirates

17 %

Sep 16, 2025 - MLB

Chicago Cubs
4 :  1
Pittsburgh Pirates

Sep 15, 2025 - MLB

Chicago Cubs
4 :  0
Pittsburgh Pirates

Aug 17, 2025 - MLB

Pittsburgh Pirates
3 :  4
Chicago Cubs

Aug 16, 2025 - MLB

Pittsburgh Pirates
1 :  3
Chicago Cubs

Aug 15, 2025 - MLB

Pittsburgh Pirates
3 :  2
Chicago Cubs

Jun 15, 2025 - MLB

Pittsburgh Pirates
2 :  3
Chicago Cubs

Chicago Cubs - Pittsburgh Pirates Key Points

  1. Chicago Cubs is 6-1 SU in its last 7 games against Pittsburgh.
  2. Chicago Cubs is 8-1 SU in its last 9 games when playing on the road against Pittsburgh.
  3. Pittsburgh is 0-5 SU in its last 5 games at home.
  4. Pittsburgh is 1-10 SU in its last 11 games.

Our Chicago Cubs vs Pittsburgh Pirates Prediction

At this point, the Cubs have totally crushed the Pirates’ morale after holding them to one run in the last two games. The Cubs are 6-1 in their last 7 games against Pittsburgh and 8-1 in their last 9 games when playing on the road against the same team. Matthew Boyd has pitched to a 5.79 ERA over his last five starts, but he has only surrendered 4 earned runs or an average of 1.3 earned runs per game across his last three starts against the Pirates.

Pirates starter Johan Oviedo has been remarkable lately, posting a 3-2 record with a 3.05 ERA in his last five starts. However, it all goes back again to the Pirates’ inability to provide adequate run support to their starters. Oviedo could come through with stellar numbers on the mound on Wednesday, but all of his effort would mean nothing if the offense cannot drive in enough runs to win a baseball game.

Our betting prediction for the Chicago Cubs vs. the Pittsburgh Pirates: the Cubs -1.5 Runs

Prediction:

 

The Cubs -1.5 Runs

+104
$400+ offered for betting!

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Chicago Cubs vs Pittsburgh Pirates Picks