Chicago Cubs vs Pittsburgh Pirates Prediction & Picks - MLB

USA - MLB

Chicago Cubs
9/16/25 18:40
Pittsburgh Pirates

Prediction:

 

Under 7 runs.

-118
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 by Carlos Zabala in MLB Picks

On Sunday, the Cubs had won their game against the Rays, scoring four runs. On Monday, in their new series at PNC Park against the Pirates, the Cubs won again, scoring four runs, without allowing a single to the Pirates, who were dominated by Jameson Taillon. The veteran Cubs starting pitcher earned his 10th win of the season, pitching six scoreless innings with just two hits.

Busch hit his 28th home run of the year in the third inning, and Crow-Armstrong hit his 29th home run of the season. Meanwhile, Swanson had a game in which he did it all; the Cubs shortstop went 2-for-4, hit an RBI double that landed off the wall, displayed solid defense by blocking numerous ground balls without committing an error, and also stole bases.

But the Cubs' party could be spoiled when they face this season's likely Cy Young Award winner and last season's Rookie of the Year, Paul Skenes, on Tuesday. He will be handling the starting pitching, and his mere presence has the Pirates as betting favorites with -130 odds at the bookmakers. Pittsburgh has won four of Skenes' last five starts, the same stretch since August 18 when he allowed just three ERs in 30 innings of work.

Chicago Cubs vs Pittsburgh Pirates Form

Table

Teams % P W L
4
Chicago Cubs
Chicago Cubs
0.573 150 86 64
27
Pittsburgh Pirates
Pittsburgh Pirates
0.43 151 65 86

Chicago Cubs and Pittsburgh Pirates Latest Matches

Chicago Cubs
Chicago Cubs Latest matches
W W W L W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Sep 15, 2025 - MLB

Chicago Cubs
4 :  0
Pittsburgh Pirates

Sep 14, 2025 - MLB

Tampa Bay Rays
3 :  4
Chicago Cubs

Sep 13, 2025 - MLB

Tampa Bay Rays
5 :  4
Chicago Cubs

Sep 12, 2025 - MLB

Tampa Bay Rays
4 :  6
Chicago Cubs

Sep 10, 2025 - MLB

Chicago Cubs
3 :  2
Atlanta Braves

Sep 9, 2025 - MLB

Chicago Cubs
6 :  1
Atlanta Braves
W L L W L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Sep 14, 2025 - MLB

Tampa Bay Rays
3 :  4
Chicago Cubs

Sep 13, 2025 - MLB

Tampa Bay Rays
5 :  4
Chicago Cubs

Sep 12, 2025 - MLB

Tampa Bay Rays
4 :  6
Chicago Cubs

Sep 7, 2025 - MLB

Washington Nationals
6 :  3
Chicago Cubs

Sep 6, 2025 - MLB

Washington Nationals
2 :  1
Chicago Cubs

Sep 5, 2025 - MLB

Washington Nationals
5 :  11
Chicago Cubs
W L L W W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Sep 15, 2025 - MLB

Chicago Cubs
4 :  0
Pittsburgh Pirates

Sep 10, 2025 - MLB

Chicago Cubs
3 :  2
Atlanta Braves

Sep 9, 2025 - MLB

Chicago Cubs
6 :  1
Atlanta Braves

Sep 8, 2025 - MLB

Chicago Cubs
1 :  4
Atlanta Braves

Aug 31, 2025 - MLB

Chicago Cubs
5 :  6
Colorado Rockies

Aug 30, 2025 - MLB

Chicago Cubs
4 :  3
Colorado Rockies
Pittsburgh Pirates
Pittsburgh Pirates Latest matches
L L L W L L
Victories

1/6 (17%)

Defeats

5/6 (83%)

Sep 15, 2025 - MLB

Chicago Cubs
4 :  0
Pittsburgh Pirates

Sep 14, 2025 - MLB

Pittsburgh Pirates
3 :  4
Washington Nationals

Sep 13, 2025 - MLB

Pittsburgh Pirates
5 :  1
Washington Nationals

Sep 12, 2025 - MLB

Pittsburgh Pirates
5 :  6
Washington Nationals

Sep 11, 2025 - MLB

Pittsburgh Pirates
2 :  3
Baltimore Orioles

Sep 10, 2025 - MLB

Pittsburgh Pirates
1 :  2
Baltimore Orioles
W W L L L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Sep 15, 2025 - MLB

Chicago Cubs
4 :  0
Pittsburgh Pirates

Sep 7, 2025 - MLB

Milwaukee Brewers
10 :  2
Pittsburgh Pirates

Sep 6, 2025 - MLB

Milwaukee Brewers
4 :  1
Pittsburgh Pirates

Sep 5, 2025 - MLB

Milwaukee Brewers
5 :  2
Pittsburgh Pirates

Sep 4, 2025 - MLB

Los Angeles Dodgers
3 :  5
Pittsburgh Pirates

Sep 3, 2025 - MLB

Los Angeles Dodgers
0 :  3
Pittsburgh Pirates
L L L L W L
Victories

1/6 (17%)

Defeats

5/6 (83%)

Sep 14, 2025 - MLB

Pittsburgh Pirates
3 :  4
Washington Nationals

Sep 13, 2025 - MLB

Pittsburgh Pirates
5 :  1
Washington Nationals

Sep 12, 2025 - MLB

Pittsburgh Pirates
5 :  6
Washington Nationals

Sep 11, 2025 - MLB

Pittsburgh Pirates
2 :  3
Baltimore Orioles

Sep 10, 2025 - MLB

Pittsburgh Pirates
1 :  2
Baltimore Orioles

Sep 9, 2025 - MLB

Pittsburgh Pirates
2 :  3
Baltimore Orioles

Chicago Cubs against Pittsburgh Pirates : Head to Head (H2H)

Chicago Cubs

83 %

Pittsburgh Pirates

17 %

Sep 15, 2025 - MLB

Chicago Cubs
4 :  0
Pittsburgh Pirates

Aug 17, 2025 - MLB

Pittsburgh Pirates
3 :  4
Chicago Cubs

Aug 16, 2025 - MLB

Pittsburgh Pirates
1 :  3
Chicago Cubs

Aug 15, 2025 - MLB

Pittsburgh Pirates
3 :  2
Chicago Cubs

Jun 15, 2025 - MLB

Pittsburgh Pirates
2 :  3
Chicago Cubs

Jun 14, 2025 - MLB

Pittsburgh Pirates
1 :  2
Chicago Cubs

Chicago Cubs - Pittsburgh Pirates Key Points

  1. Eight of the last 10 Pirates games have resulted in a Game Total of UNDER in the betting
  2. Eight of the last 10 Cubs-Pirates games have resulted in a Game Total of UNDER in the betting
  3. The Pirates have only produced 3.6 runs per game this season
  4. The Pirates have lost nine of their last 10 games.

Our Chicago Cubs vs Pittsburgh Pirates Prediction

A recurring bet that betting sites receive on games in which Skenes pitches is that the game will end up being a low-run, all-under game. It's generally a well-considered and consistent bet, considering both Skenes' dominance and the Pirates' poor hitting.

On Monday, they gave another example of a lost offense at the plate. It wasn't until the 9th inning that they generated a threat to the Cubs by loading the bases. The Cubs manager brought in Brad Keller to get just one out, and he did so by striking out Triolo, who went 0-for-4 with a strikeout at the crucial moment.

Skenes struck out five Cubs in five scoreless innings in his last start against the Cubs in Chicago.

Our prediction for Pirates vs Cubs is: Under 7 runs.

Prediction:

 

Under 7 runs.

-118
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Chicago Cubs vs Pittsburgh Pirates Picks