Chicago Cubs vs Houston Astros Prediction & Picks - MLB

USA - MLB

Chicago Cubs
6/29/25 14:10
Houston Astros

Prediction:

 

Under 7.5

-102
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 by Erik Gibbs in MLB Picks

The Chicago Cubs and Houston Astros face off today in the rubber match of a three-game series at Daikin Park, with both clubs entering the contest at 49-34 on the season. Each team has claimed one victory in the series so far, setting up a pivotal showdown between two division leaders.

The Cubs dropped the opener 7-4 but bounced back with a resounding 12-3 win in game two. After falling behind 2-1 early, Chicago’s offense erupted, scoring 11 unanswered runs to cruise to victory. That offensive surge helped maintain their slim lead in the competitive NL Central.

The Cubs have found a bit of momentum in recent days, winning three of their last four games. Prior to arriving in Houston, they split a four-game set against division rival St. Louis and dropped two of three against the Mariners.

The Astros had their six-game win streak snapped in Saturday’s loss but remain in firm control of the AL West. Before this series, Houston swept the Phillies in three games and took two of three from the Angels. Their dominant home record of 31-14 has been a key factor in their success, and they’ll aim to add to that today with Framber Valdez on the mound.

Chicago Cubs vs Houston Astros Form

Table

Teams % P W L
3
Houston Astros
Houston Astros
0.59 83 49 34
3
Chicago Cubs
Chicago Cubs
0.59 83 49 34

Chicago Cubs and Houston Astros Latest Matches

Chicago Cubs
Chicago Cubs Latest matches
L L W W W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Jun 28, 2025 - MLB

Chicago Cubs
12 :  3
Houston Astros

Jun 27, 2025 - MLB

Chicago Cubs
4 :  7
Houston Astros

Jun 26, 2025 - MLB

Chicago Cubs
3 :  0
St. Louis Cardinals

Jun 25, 2025 - MLB

Chicago Cubs
8 :  0
St. Louis Cardinals

Jun 24, 2025 - MLB

Chicago Cubs
7 :  8
St. Louis Cardinals

Jun 23, 2025 - MLB

Chicago Cubs
2 :  8
St. Louis Cardinals
W W L L W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Jun 22, 2025 - MLB

Seattle Mariners
14 :  6
Chicago Cubs

Jun 21, 2025 - MLB

Seattle Mariners
7 :  10
Chicago Cubs

Jun 20, 2025 - MLB

Seattle Mariners
9 :  4
Chicago Cubs

Jun 19, 2025 - MLB

Milwaukee Brewers
8 :  7
Chicago Cubs

Jun 17, 2025 - MLB

Milwaukee Brewers
3 :  5
Chicago Cubs

Jun 15, 2025 - MLB

Pittsburgh Pirates
2 :  3
Chicago Cubs
L L W W L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Jun 28, 2025 - MLB

Chicago Cubs
12 :  3
Houston Astros

Jun 27, 2025 - MLB

Chicago Cubs
4 :  7
Houston Astros

Jun 26, 2025 - MLB

Chicago Cubs
3 :  0
St. Louis Cardinals

Jun 25, 2025 - MLB

Chicago Cubs
8 :  0
St. Louis Cardinals

Jun 24, 2025 - MLB

Chicago Cubs
7 :  8
St. Louis Cardinals

Jun 23, 2025 - MLB

Chicago Cubs
2 :  8
St. Louis Cardinals
Houston Astros
Houston Astros Latest matches
L W W W L W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Jun 28, 2025 - MLB

Chicago Cubs
12 :  3
Houston Astros

Jun 27, 2025 - MLB

Chicago Cubs
4 :  7
Houston Astros

Jun 26, 2025 - MLB

Philadelphia Phillies
1 :  2
Houston Astros

Jun 25, 2025 - MLB

Philadelphia Phillies
0 :  2
Houston Astros

Jun 24, 2025 - MLB

Philadelphia Phillies
0 :  1
Houston Astros

Jun 22, 2025 - MLB

Houston Astros
8 :  7
Los Angeles Angels
W W W W W L
Victories

5/6 (83%)

Defeats

1/6 (17%)

Jun 28, 2025 - MLB

Chicago Cubs
12 :  3
Houston Astros

Jun 27, 2025 - MLB

Chicago Cubs
4 :  7
Houston Astros

Jun 26, 2025 - MLB

Philadelphia Phillies
1 :  2
Houston Astros

Jun 25, 2025 - MLB

Philadelphia Phillies
0 :  2
Houston Astros

Jun 24, 2025 - MLB

Philadelphia Phillies
0 :  1
Houston Astros

Jun 15, 2025 - MLB

Minnesota Twins
1 :  2
Houston Astros
W W L W W L
Victories

4/6 (67%)

Defeats

2/6 (33%)

Jun 22, 2025 - MLB

Houston Astros
8 :  7
Los Angeles Angels

Jun 21, 2025 - MLB

Houston Astros
1 :  9
Los Angeles Angels

Jun 20, 2025 - MLB

Houston Astros
3 :  2
Los Angeles Angels

Jun 19, 2025 - MLB

Houston Astros
4 :  6
Athletics

Jun 18, 2025 - MLB

Houston Astros
11 :  4
Athletics

Jun 17, 2025 - MLB

Houston Astros
13 :  3
Athletics

Chicago Cubs against Houston Astros : Head to Head (H2H)

Chicago Cubs

67 %

Houston Astros

33 %

Jun 28, 2025 - MLB

Chicago Cubs
12 :  3
Houston Astros

Jun 27, 2025 - MLB

Chicago Cubs
4 :  7
Houston Astros

Apr 24, 2024 - MLB

Houston Astros
3 :  4
Chicago Cubs

Apr 23, 2024 - MLB

Houston Astros
2 :  7
Chicago Cubs

May 29, 2019 - MLB

Chicago Cubs
2 :  1
Houston Astros

May 28, 2019 - MLB

Chicago Cubs
6 :  9
Houston Astros

Chicago Cubs - Houston Astros Key Points

  1. The Astros are 8-0 in their last 8 games at Daikin Park following a home loss
  2. The Cubs are 0-4 in their last 4 games vs. American League teams following a win
  3. The Astros are 4-0 covering the run line in their last 4 games as favorites vs. NL Central teams after a loss
  4. The Cubs are 0-6 covering the run line in their last 6 games as road underdogs after a win.

Our Chicago Cubs vs Houston Astros Prediction

Despite some inconsistency, Chicago remains atop the NL Central, thanks in part to their solid road performance. They carry a 24-19 record away from Wrigley Field into today’s game, and they'll look to keep that success going behind starter Jameson Taillon.

Taillon enters the game with a 7-5 record and a 4.47 ERA across 90.2 innings. However, recent outings have not been kind to him — he’s surrendered 13 earned runs and 16 hits over just eight innings in his last two starts combined. Chicago will need Taillon to rebound if they hope to secure a series win against a red-hot Houston team.

Valdez has been outstanding this season, boasting an 8-4 record with a 2.88 ERA and 1.13 WHIP over 103 innings. He’s been especially dominant lately, allowing two earned runs or fewer in five consecutive starts. Valdez’s form, combined with the Astros’ home-field advantage, gives Houston a strong chance to bounce back and take the series.

With both teams eyeing postseason contention, today’s matchup could carry weight beyond the regular season. It's a battle of strength versus momentum, with two of MLB’s best squaring off in what promises to be a compelling finale. Our prediction for Houston Astros vs. Chicago Cubs: Astros to win.

Prediction:

 

Under 7.5

-102
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Chicago Cubs vs Houston Astros Picks