Chicago Cubs vs Houston Astros Prediction & Picks - MLB

USA - MLB

Chicago Cubs
6/27/25 20:10
Houston Astros

Prediction:

 

Houston Astros win both halves

-110
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 by Erik Gibbs in MLB Picks

The Houston Astros and Chicago Cubs will meet today at Daikin Park in an interleague clash that sees two playoff hopefuls from opposite leagues trying to build momentum as the season approaches its midpoint.

The Chicago Cubs hold a 48-33 record after finishing a four-game set against the Cardinals with a split, posting results of 2-8, 7-8, 8-0, and 3-0. They'll continue their road trip on Friday, where they've been decent but not dominant, sitting four games over .500 away from home.

Before facing St. Louis, the Cubs dropped two of three games to the Mariners and split a brief two-game series with the Brewers. They've gone 3-3 over their last six contests and currently lead the NL Central.

Meanwhile, the Houston Astros also sit at 48-33 following a sweep of the Phillies. In the third game of that series, they gave up a tying run in the eighth but answered with a go-ahead score in the bottom half to seal the win.

Leading into that matchup, Houston took two of three from the Angels and split a four-game series with the Athletics. The Astros come into this weekend riding a four-game win streak and sit atop the AL West standings.

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Chicago Cubs vs Houston Astros Form

Table

Teams % P W L
3
Houston Astros
Houston Astros
0.593 81 48 33
3
Chicago Cubs
Chicago Cubs
0.593 81 48 33

Chicago Cubs and Houston Astros Latest Matches

Chicago Cubs
Chicago Cubs Latest matches
W L L L W W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Jun 26, 2025 - MLB

Chicago Cubs
3 :  0
St. Louis Cardinals

Jun 25, 2025 - MLB

Chicago Cubs
8 :  0
St. Louis Cardinals

Jun 24, 2025 - MLB

Chicago Cubs
7 :  8
St. Louis Cardinals

Jun 23, 2025 - MLB

Chicago Cubs
2 :  8
St. Louis Cardinals

Jun 22, 2025 - MLB

Seattle Mariners
14 :  6
Chicago Cubs

Jun 21, 2025 - MLB

Seattle Mariners
7 :  10
Chicago Cubs
W W L L W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Jun 22, 2025 - MLB

Seattle Mariners
14 :  6
Chicago Cubs

Jun 21, 2025 - MLB

Seattle Mariners
7 :  10
Chicago Cubs

Jun 20, 2025 - MLB

Seattle Mariners
9 :  4
Chicago Cubs

Jun 19, 2025 - MLB

Milwaukee Brewers
8 :  7
Chicago Cubs

Jun 17, 2025 - MLB

Milwaukee Brewers
3 :  5
Chicago Cubs

Jun 15, 2025 - MLB

Pittsburgh Pirates
2 :  3
Chicago Cubs
W L L L W W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Jun 26, 2025 - MLB

Chicago Cubs
3 :  0
St. Louis Cardinals

Jun 25, 2025 - MLB

Chicago Cubs
8 :  0
St. Louis Cardinals

Jun 24, 2025 - MLB

Chicago Cubs
7 :  8
St. Louis Cardinals

Jun 23, 2025 - MLB

Chicago Cubs
2 :  8
St. Louis Cardinals

Jun 11, 2025 - MLB

Chicago Cubs
2 :  7
Philadelphia Phillies

Jun 10, 2025 - MLB

Chicago Cubs
8 :  4
Philadelphia Phillies
Houston Astros
Houston Astros Latest matches
W W L W W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Jun 26, 2025 - MLB

Philadelphia Phillies
1 :  2
Houston Astros

Jun 25, 2025 - MLB

Philadelphia Phillies
0 :  2
Houston Astros

Jun 24, 2025 - MLB

Philadelphia Phillies
0 :  1
Houston Astros

Jun 22, 2025 - MLB

Houston Astros
8 :  7
Los Angeles Angels

Jun 21, 2025 - MLB

Houston Astros
1 :  9
Los Angeles Angels

Jun 20, 2025 - MLB

Houston Astros
3 :  2
Los Angeles Angels
W W W W W W
Victories

6/6 (100%)

Defeats

0/6 (0%)

Jun 26, 2025 - MLB

Philadelphia Phillies
1 :  2
Houston Astros

Jun 25, 2025 - MLB

Philadelphia Phillies
0 :  2
Houston Astros

Jun 24, 2025 - MLB

Philadelphia Phillies
0 :  1
Houston Astros

Jun 15, 2025 - MLB

Minnesota Twins
1 :  2
Houston Astros

Jun 14, 2025 - MLB

Minnesota Twins
2 :  3
Houston Astros

Jun 13, 2025 - MLB

Minnesota Twins
3 :  10
Houston Astros
W W L W W L
Victories

4/6 (67%)

Defeats

2/6 (33%)

Jun 22, 2025 - MLB

Houston Astros
8 :  7
Los Angeles Angels

Jun 21, 2025 - MLB

Houston Astros
1 :  9
Los Angeles Angels

Jun 20, 2025 - MLB

Houston Astros
3 :  2
Los Angeles Angels

Jun 19, 2025 - MLB

Houston Astros
4 :  6
Athletics

Jun 18, 2025 - MLB

Houston Astros
11 :  4
Athletics

Jun 17, 2025 - MLB

Houston Astros
13 :  3
Athletics

Chicago Cubs against Houston Astros : Head to Head (H2H)

Chicago Cubs

60 %

Houston Astros

40 %

Apr 24, 2024 - MLB

Houston Astros
3 :  4
Chicago Cubs

Apr 23, 2024 - MLB

Houston Astros
2 :  7
Chicago Cubs

May 29, 2019 - MLB

Chicago Cubs
2 :  1
Houston Astros

May 28, 2019 - MLB

Chicago Cubs
6 :  9
Houston Astros

May 27, 2019 - MLB

Chicago Cubs
5 :  6
Houston Astros

Chicago Cubs - Houston Astros Key Points

  1. The favorites are 10-0 in the Cubs’ last 10 home games
  2. The Astros are 38-43 against the run line
  3. The Cubs are 40-41 against the run line
  4. The Over/Under is 32-45-4 for the Astros
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Our Chicago Cubs vs Houston Astros Prediction

Brandon Walter will likely start the opener for Houston. The rookie left-hander struggled in his last appearance, allowing seven runs over six innings against the Angels and taking the loss.

Despite that outing, he’s shown promise in three of his four starts, giving up two or fewer runs in those games. So far this season, Walter holds a 3.80 ERA, a 1.10 WHIP, and a 0-1 record across 23.1 innings. He faced the Cubs once before, giving up two runs in two innings.

For Chicago, Cade Horton gets the call. The right-hander had a rough outing his last time out but has otherwise impressed in his first MLB season. He owns a 3.48 ERA for the month and a 3.73 ERA with a 1.29 WHIP and a 3-1 record over 41 innings overall. Friday will mark his first career appearance against the Astros.

This game leans Houston’s way, especially given their home-field advantage and pitching matchup. Valdez is the more reliable starter, and the Astros lineup has more firepower top to bottom. While the Cubs have enough talent to pull off an upset, they’ll need early offense and a strong bullpen outing to stay in it. Our prediction for Houston Astros vs. Chicago Cubs: Astros to win.

Prediction:

 

Houston Astros win both halves

-110
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Chicago Cubs vs Houston Astros Picks
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