Chicago Cubs vs Chicago White Sox Prediction & Picks - MLB

USA - MLB

Chicago Cubs
7/27/25 14:10
Chicago White Sox

Prediction:

 

Over 9 runs.

-105
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 by Carlos Zabala in MLB Picks

Despite the Cubs' marked dominance in recent years when playing against their crosstown rival, the White Sox, it was anticipated that this trend could change for Friday's game, and that's what happened when the White Sox won 12-5 over a Cubs team that lost their previous series against the Royals and also the division lead to the Brewers.

Colson Montgomery, the rookie sensation and shortstop for the White Sox, is determined not to be overlooked in MLB and is hotter than ever since July 18, when MLB resumed after the All-Star Break. Since then, Montgomery failed to get at least one hit on July 19; he had eight hits since the All-Star break and, before Saturday's game, had a streak of three consecutive home runs. On Friday, Montgomery homered, but young catcher Edgar Cuero stole the spotlight with a four-hit game. Leadoff hitter Meidroth went 3-for-5 in the White Sox's 12-5 rout of the Cubs in the first inning of the series.

The Cubs, through Holton, were able to win Game 2, where Happ hit his 14th home run and Shaw his 6th. The White Sox's only run in Saturday's loss was Tauchman's solo home run.

The Game 3 pitching duel: Brown for the Cubs versus Taylor for the Sox.

Chicago Cubs vs Chicago White Sox Form

Table

Teams % P W L
2
Chicago Cubs
Chicago Cubs
0.587 104 61 43
29
Chicago White Sox
Chicago White Sox
0.362 105 38 67

Chicago Cubs and Chicago White Sox Latest Matches

Chicago Cubs
Chicago Cubs Latest matches
L L L W L W
Victories

2/6 (33%)

Defeats

4/6 (67%)

Jul 26, 2025 - MLB

Chicago Cubs
6 :  1
Chicago White Sox

Jul 25, 2025 - MLB

Chicago Cubs
5 :  12
Chicago White Sox

Jul 23, 2025 - MLB

Kansas City Royals
8 :  4
Chicago Cubs

Jul 22, 2025 - MLB

Kansas City Royals
0 :  6
Chicago Cubs

Jul 21, 2025 - MLB

Kansas City Royals
12 :  4
Chicago Cubs

Jul 20, 2025 - MLB

Boston Red Sox
6 :  1
Chicago Cubs
W W L L L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Jul 23, 2025 - MLB

Kansas City Royals
8 :  4
Chicago Cubs

Jul 22, 2025 - MLB

Kansas City Royals
0 :  6
Chicago Cubs

Jul 21, 2025 - MLB

Kansas City Royals
12 :  4
Chicago Cubs

Jul 20, 2025 - MLB

Boston Red Sox
6 :  1
Chicago Cubs

Jul 19, 2025 - MLB

Boston Red Sox
0 :  6
Chicago Cubs

Jul 18, 2025 - MLB

Boston Red Sox
1 :  4
Chicago Cubs
W L W W L W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Jul 26, 2025 - MLB

Chicago Cubs
6 :  1
Chicago White Sox

Jul 25, 2025 - MLB

Chicago Cubs
5 :  12
Chicago White Sox

Jul 13, 2025 - MLB

Chicago Cubs
4 :  1
New York Yankees

Jul 12, 2025 - MLB

Chicago Cubs
5 :  2
New York Yankees

Jul 11, 2025 - MLB

Chicago Cubs
0 :  11
New York Yankees

Jul 10, 2025 - MLB

Chicago Cubs
8 :  1
Minnesota Twins
Chicago White Sox
Chicago White Sox Latest matches
W W L W W L
Victories

4/6 (67%)

Defeats

2/6 (33%)

Jul 26, 2025 - MLB

Chicago Cubs
6 :  1
Chicago White Sox

Jul 25, 2025 - MLB

Chicago Cubs
5 :  12
Chicago White Sox

Jul 23, 2025 - MLB

Chicago White Sox
11 :  9
Tampa Bay Rays

Jul 22, 2025 - MLB

Chicago White Sox
3 :  4
Tampa Bay Rays

Jul 21, 2025 - MLB

Chicago White Sox
8 :  3
Tampa Bay Rays

Jul 20, 2025 - MLB

Chicago White Sox
7 :  2
Pittsburgh Pirates
L W L L W L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Jul 26, 2025 - MLB

Chicago Cubs
6 :  1
Chicago White Sox

Jul 25, 2025 - MLB

Chicago Cubs
5 :  12
Chicago White Sox

Jul 13, 2025 - MLB

Cleveland Guardians
6 :  5
Chicago White Sox

Jul 12, 2025 - MLB

Cleveland Guardians
6 :  2
Chicago White Sox

Jul 11, 2025 - MLB

Cleveland Guardians
4 :  5
Chicago White Sox

Jul 11, 2025 - MLB

Cleveland Guardians
4 :  2
Chicago White Sox
W W W W L W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Jul 23, 2025 - MLB

Chicago White Sox
11 :  9
Tampa Bay Rays

Jul 22, 2025 - MLB

Chicago White Sox
3 :  4
Tampa Bay Rays

Jul 21, 2025 - MLB

Chicago White Sox
8 :  3
Tampa Bay Rays

Jul 20, 2025 - MLB

Chicago White Sox
7 :  2
Pittsburgh Pirates

Jul 19, 2025 - MLB

Chicago White Sox
10 :  4
Pittsburgh Pirates

Jul 18, 2025 - MLB

Chicago White Sox
10 :  1
Pittsburgh Pirates

Chicago Cubs against Chicago White Sox : Head to Head (H2H)

Chicago Cubs

83 %

Chicago White Sox

17 %

Jul 26, 2025 - MLB

Chicago Cubs
6 :  1
Chicago White Sox

Jul 25, 2025 - MLB

Chicago Cubs
5 :  12
Chicago White Sox

May 18, 2025 - MLB

Chicago White Sox
2 :  6
Chicago Cubs

May 17, 2025 - MLB

Chicago White Sox
3 :  7
Chicago Cubs

May 16, 2025 - MLB

Chicago White Sox
3 :  13
Chicago Cubs

Feb 22, 2025 - MLB Spring Training

Chicago White Sox
3 :  7
Chicago Cubs

Chicago Cubs - Chicago White Sox Key Points

  1. The Cubs won nine of their last 10 games against the White Sox
  2. Cubs, the team with the most runs scored in MLB with 5.3
  3. Cubs, the second-most stolen bases in MLB in 2025
  4. White Sox 22-30 record at Rate Field

Our Chicago Cubs vs Chicago White Sox Prediction

When this same series was played in May at Wrigley Field, none of the three games generated a Game Total of UNDER; Now in July at Rate Field, although Game 2 was only a 7-run game, there were three home runs. Game 1 was won 12-5 by the White Sox as betting underdogs and was a 5-home run game; there are a pair of hot bats for the White Sox, while for the Cubs, Suzuki and Tucker are always a latent threat hitting at the plate. Our prediction for White Sox vs Cubs is: Over 9 runs.

Prediction:

 

Over 9 runs.

-105
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Chicago Cubs vs Chicago White Sox Picks