Chicago Cubs vs Chicago White Sox Prediction & Picks - MLB

USA - MLB

Chicago Cubs
7/25/25 19:40
Chicago White Sox

Prediction:

 

White Sox +1.5.

-114
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 by Carlos Zabala in MLB Picks

Once again, the two Chicago teams, the White Sox and Cubs, meet at Rate Field to kick off a new weekend series on Friday. So far, the Cubs have been dominant in the matchup between the two teams from the Windy City, so much so that the Cubs have won nine of their last ten games against the White Sox, including three at Wrigley Field in 2025, where the Cubs swept the White Sox, having started as favorites in each game with odds of -200 or lower.

However, there are some things that suggest that the July 25 game at Rate Field, even though the Cubs start as favorites at -180 odds, could be a positive one for the White Sox, as, strangely, it's the White Sox who come into this series in good form, rather than the Cubs.

The Whites won their last two series, sweeping the Pirates at PNC Park and winning a series against the Rays on Wednesday, also on the road. Rookie SS Corson Montgomery had a monster game, going 2-for-5 with a double and a home run and driving in 5 runs in an 11-9 win over the Rays.

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Chicago Cubs vs Chicago White Sox Form

Table

Teams % P W L
3
Chicago Cubs
Chicago Cubs
0.588 102 60 42
29
Chicago White Sox
Chicago White Sox
0.359 103 37 66

Chicago Cubs and Chicago White Sox Latest Matches

Chicago Cubs
Chicago Cubs Latest matches
W W L L L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Jul 23, 2025 - MLB

Kansas City Royals
8 :  4
Chicago Cubs

Jul 22, 2025 - MLB

Kansas City Royals
0 :  6
Chicago Cubs

Jul 21, 2025 - MLB

Kansas City Royals
12 :  4
Chicago Cubs

Jul 20, 2025 - MLB

Boston Red Sox
6 :  1
Chicago Cubs

Jul 19, 2025 - MLB

Boston Red Sox
0 :  6
Chicago Cubs

Jul 18, 2025 - MLB

Boston Red Sox
1 :  4
Chicago Cubs
W W L L L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Jul 23, 2025 - MLB

Kansas City Royals
8 :  4
Chicago Cubs

Jul 22, 2025 - MLB

Kansas City Royals
0 :  6
Chicago Cubs

Jul 21, 2025 - MLB

Kansas City Royals
12 :  4
Chicago Cubs

Jul 20, 2025 - MLB

Boston Red Sox
6 :  1
Chicago Cubs

Jul 19, 2025 - MLB

Boston Red Sox
0 :  6
Chicago Cubs

Jul 18, 2025 - MLB

Boston Red Sox
1 :  4
Chicago Cubs
L L W L W W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Jul 13, 2025 - MLB

Chicago Cubs
4 :  1
New York Yankees

Jul 12, 2025 - MLB

Chicago Cubs
5 :  2
New York Yankees

Jul 11, 2025 - MLB

Chicago Cubs
0 :  11
New York Yankees

Jul 10, 2025 - MLB

Chicago Cubs
8 :  1
Minnesota Twins

Jul 9, 2025 - MLB

Chicago Cubs
2 :  4
Minnesota Twins

Jul 8, 2025 - MLB

Chicago Cubs
1 :  8
Minnesota Twins
Chicago White Sox
Chicago White Sox Latest matches
W W W W L W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Jul 23, 2025 - MLB

Chicago White Sox
11 :  9
Tampa Bay Rays

Jul 22, 2025 - MLB

Chicago White Sox
3 :  4
Tampa Bay Rays

Jul 21, 2025 - MLB

Chicago White Sox
8 :  3
Tampa Bay Rays

Jul 20, 2025 - MLB

Chicago White Sox
7 :  2
Pittsburgh Pirates

Jul 19, 2025 - MLB

Chicago White Sox
10 :  4
Pittsburgh Pirates

Jul 18, 2025 - MLB

Chicago White Sox
10 :  1
Pittsburgh Pirates
L W L L W L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Jul 13, 2025 - MLB

Cleveland Guardians
6 :  5
Chicago White Sox

Jul 12, 2025 - MLB

Cleveland Guardians
6 :  2
Chicago White Sox

Jul 11, 2025 - MLB

Cleveland Guardians
4 :  5
Chicago White Sox

Jul 11, 2025 - MLB

Cleveland Guardians
4 :  2
Chicago White Sox

Jul 9, 2025 - MLB

Toronto Blue Jays
1 :  2
Chicago White Sox

Jul 8, 2025 - MLB

Toronto Blue Jays
6 :  1
Chicago White Sox
W W W W L W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Jul 23, 2025 - MLB

Chicago White Sox
11 :  9
Tampa Bay Rays

Jul 22, 2025 - MLB

Chicago White Sox
3 :  4
Tampa Bay Rays

Jul 21, 2025 - MLB

Chicago White Sox
8 :  3
Tampa Bay Rays

Jul 20, 2025 - MLB

Chicago White Sox
7 :  2
Pittsburgh Pirates

Jul 19, 2025 - MLB

Chicago White Sox
10 :  4
Pittsburgh Pirates

Jul 18, 2025 - MLB

Chicago White Sox
10 :  1
Pittsburgh Pirates

Chicago Cubs against Chicago White Sox : Head to Head (H2H)

Chicago Cubs

100 %

Chicago White Sox

0 %

May 18, 2025 - MLB

Chicago White Sox
2 :  6
Chicago Cubs

May 17, 2025 - MLB

Chicago White Sox
3 :  7
Chicago Cubs

May 16, 2025 - MLB

Chicago White Sox
3 :  13
Chicago Cubs

Feb 22, 2025 - MLB Spring Training

Chicago White Sox
3 :  7
Chicago Cubs

Aug 10, 2024 - MLB

Chicago Cubs
3 :  1
Chicago White Sox

Aug 9, 2024 - MLB

Chicago Cubs
7 :  6
Chicago White Sox

Chicago Cubs - Chicago White Sox Key Points

  1. Cubs second in MLB with most stolen bases in 2025
  2. White Sox 21-29 record at Rate Field
  3. Cubs 10-5 record after a day's rest
  4. White Sox pitching: 9th fewest home runs allowed in MLB
Up to $150 to bet on Chicago Cubs - Chicago White Sox! 

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Our Chicago Cubs vs Chicago White Sox Prediction

One reason Friday could be a good day for the White Sox is the pitcher again, who, despite allowing 10 hits in his last start, has gone on to win the game in 5 of the last 5 times Houser started. In that same span, he posted a 1.65 ERA. Meanwhile, the Cubs are coming off a Wednesday loss to the Royals, along with unexpectedly losing the division lead to the Brewers. Our prediction for Cubs vs White Sox is: White Sox +1.5.

Prediction:

 

White Sox +1.5.

-114
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All tips are fully researched and given in good faith, but profits cannot be guaranteed.

Chicago Cubs vs Chicago White Sox Picks
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