Charlotte 49ers vs South Florida Bulls Prediction & Picks - NCAA

USA - NCAA

Charlotte 49ers
10/3/25 19:00
South Florida Bulls

Prediction:

 

USF -27.5

-110
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 by Travis Pulver | in NCAA Picks

The Charlotte 49ers will head out onto the road for the first time this season when they head down to southern Florida to take on the USF Bulls at Raymond James Stadium in Tampa, FL. Gametime for this American Athletic Conference opener for both teams is set to kick off at 7 p.m. EST on Friday, Oct. 3.

Charlotte will certainly have its hands full facing a USF team that opened the season against three ranked teams, beating two of them. The Bulls dominated No. 25 Boise State in their season opener, 34-7, before winning a close one against No. 13 Florida, 18-16. But the following week saw them come back down to Earth after getting manhandled by Miami, 49-12. They dominated South Carolina State 63-14 before last week’s bye. The Bulls are not exceptional on either side of the ball, but good on both, ranked No. 55 in offensive (31.8 ppg) and defensive (21.5 ppg allowed) scoring. As for the 49ers, Charlotte opened the season with a four-game homestand and went 1-3 while scoring 31 total points in all three losses.  They struggle to run the ball, averaging 88.3 yards per game, but aren’t bad at passing it (258.3 yards per game). The 49ers are scoring 18.3 ppg while allowing 29.3.

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Charlotte 49ers vs South Florida Bulls Form

Table

Teams % P W D L
5
South Florida Bulls
South Florida Bulls
0.75 8 6 0 2
14
Charlotte 49ers
Charlotte 49ers
0 8 0 0 8

Charlotte 49ers and South Florida Bulls Latest Matches

Charlotte 49ers
Charlotte 49ers Latest matches
W W L L W L
Victories

1/4 (25%)

Draw

0/4 (0%)

Defeats

3/4 (75%)

Sep 18, 2025 - NCAA

Rice Owls
28 :  17
Charlotte 49ers

Sep 13, 2025 - NCAA

Monmouth Hawks
35 :  42
Charlotte 49ers

Sep 6, 2025 - NCAA

North Carolina Tar Heels
20 :  3
Charlotte 49ers

Aug 29, 2025 - NCAA

Appalachian State Mountaineers
34 :  11
Charlotte 49ers
L W L L W L
Victories

1/4 (25%)

Draw

0/4 (0%)

Defeats

3/4 (75%)

Sep 18, 2025 - NCAA

Rice Owls
28 :  17
Charlotte 49ers

Sep 13, 2025 - NCAA

Monmouth Hawks
35 :  42
Charlotte 49ers

Sep 6, 2025 - NCAA

North Carolina Tar Heels
20 :  3
Charlotte 49ers

Aug 29, 2025 - NCAA

Appalachian State Mountaineers
34 :  11
Charlotte 49ers
South Florida Bulls
South Florida Bulls Latest matches
L W W W L W
Victories

4/6 (67%)

Draw

0/6 (0%)

Defeats

2/6 (33%)

Sep 20, 2025 - NCAA

South Carolina State Bulldogs
14 :  63
South Florida Bulls

Sep 13, 2025 - NCAA

South Florida Bulls
12 :  49
Miami Hurricanes

Sep 6, 2025 - NCAA

South Florida Bulls
18 :  16
Florida Gators

Aug 28, 2025 - NCAA

Boise State Broncos
7 :  34
South Florida Bulls

Oct 19, 2024 - NCAA

UAB Blazers
25 :  35
South Florida Bulls

Oct 12, 2024 - NCAA

Memphis Tigers
21 :  3
South Florida Bulls
L W L W W W
Victories

3/5 (60%)

Draw

0/5 (0%)

Defeats

2/5 (40%)

Sep 20, 2025 - NCAA

South Carolina State Bulldogs
14 :  63
South Florida Bulls

Aug 28, 2025 - NCAA

Boise State Broncos
7 :  34
South Florida Bulls

Oct 19, 2024 - NCAA

UAB Blazers
25 :  35
South Florida Bulls

Oct 12, 2024 - NCAA

Memphis Tigers
21 :  3
South Florida Bulls

Sep 21, 2024 - NCAA

Miami Hurricanes
50 :  15
South Florida Bulls
W W L W W L
Victories

2/5 (40%)

Draw

0/5 (0%)

Defeats

3/5 (60%)

Sep 13, 2025 - NCAA

South Florida Bulls
12 :  49
Miami Hurricanes

Sep 6, 2025 - NCAA

South Florida Bulls
18 :  16
Florida Gators

Sep 28, 2024 - NCAA

South Florida Bulls
10 :  45
Tulane Green Wave

Sep 14, 2024 - NCAA

South Florida Bulls
49 :  24
Southern Miss Golden Eagles

Sep 7, 2024 - NCAA

South Florida Bulls
16 :  42
Alabama Crimson Tide

Charlotte 49ers - South Florida Bulls Key Points

  1. USF and Charlotte have played twice; the Bulls won both games in dominant fashion, 48-14 and 59-24.
  2. Both teams were on a bye last week.
  3. Betting Public: 92% of moneyline tickets and 78% of the handle are on USF.
  4. Betting Public: TOTAL tickets are split with roughly 50% taking the OVER and 50% taking the UNDER. But 66% of the handle is on the OVER and 34% the UNDER.
Up to $250 to bet on Charlotte 49ers - South Florida Bulls! 

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Our Charlotte 49ers vs South Florida Bulls Prediction

South Florida is not a great team like Miami, but they are a solid, good overall team without a glaring, easy-to-exploit weakness. At least not one that a team like Charlotte could take advantage of. Charlotte ranks amongst the lower third of college football teams in many significant categories, and over No. 100 in quite a few. They have some promising players on both sides of the ball, but not enough to be competitive vs. USF.

Our Charlotte vs. USF Pick: USF -27.5

Prediction:

 

USF -27.5

-110
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All tips are fully researched and given in good faith, but profits cannot be guaranteed.

Charlotte 49ers vs South Florida Bulls Picks