Arizona Cardinals vs Carolina Panthers Prediction & Picks - NFL

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Arizona Cardinals
9/14/25 16:05
Carolina Panthers

Prediction:

 

The Cardinals -6.5 Points

-115
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 by Lou Aguila | in NFL Picks

The Carolina Panthers are marching in as road underdogs (+240) against the team they have beaten in 7 out of their last 10 meetings, the Arizona Cardinals (-298), on Sunday at State Farm Stadium.

Current Form:

The Panthers lost their season-opening match against the Jacksonville Jaguars 10-26 last week. Quarterback Bryce Young completed only 18 of 35 passes for 154 yards with one touchdown and two interceptions as Carolina’s offensive line could not contain the Jaguars' aggressive pass rushing. The Panthers also failed to make an impact on the ground, covering only 113 rushing yards without a TD. Running back Chuba Hubbard ran the longest for Carolina at 16 yards, finishing the match with a team-high 54 yards.

The Cardinals fended off a late rally from the New Orleans Saints to hold on to a 20-13 win in Week 1. Arizona quarterback Kyle Murray covered 162 passing yards (21-for-29) with two touchdowns and no interceptions, while Trey Benson rushed for 69 yards. Arizona conceded 315 total yards, but allowed the Saints to convert only one of four attempts in the red zone.

Arizona Cardinals vs Carolina Panthers Form

Table

Teams Pts P W L
18 Carolina Panthers
0.471 17 8 9
30 Arizona Cardinals
0.176 17 3 14

Arizona Cardinals and Carolina Panthers Latest Matches

Arizona Cardinals
Arizona Cardinals Latest matches
L W L L W W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Sep 7, 2025 - NFL

New Orleans Saints
13 :  20
Arizona Cardinals

Jan 5, 2025 - NFL

Arizona Cardinals
47 :  24
San Francisco 49ers

Dec 28, 2024 - NFL

Los Angeles Rams
13 :  9
Arizona Cardinals

Dec 22, 2024 - NFL

Carolina Panthers
36 :  30
Arizona Cardinals

Dec 15, 2024 - NFL

Arizona Cardinals
30 :  17
New England Patriots

Dec 8, 2024 - NFL

Arizona Cardinals
18 :  30
Seattle Seahawks
W W W L W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Jan 5, 2025 - NFL

Arizona Cardinals
47 :  24
San Francisco 49ers

Dec 15, 2024 - NFL

Arizona Cardinals
30 :  17
New England Patriots

Dec 8, 2024 - NFL

Arizona Cardinals
18 :  30
Seattle Seahawks

Nov 10, 2024 - NFL

Arizona Cardinals
31 :  6
New York Jets

Nov 3, 2024 - NFL

Arizona Cardinals
29 :  9
Chicago Bears

Oct 21, 2024 - NFL

Arizona Cardinals
17 :  15
Los Angeles Chargers
W L L L L W
Victories

2/6 (33%)

Defeats

4/6 (67%)

Sep 7, 2025 - NFL

New Orleans Saints
13 :  20
Arizona Cardinals

Dec 28, 2024 - NFL

Los Angeles Rams
13 :  9
Arizona Cardinals

Dec 22, 2024 - NFL

Carolina Panthers
36 :  30
Arizona Cardinals

Dec 1, 2024 - NFL

Minnesota Vikings
23 :  22
Arizona Cardinals

Nov 24, 2024 - NFL

Seattle Seahawks
16 :  6
Arizona Cardinals

Oct 27, 2024 - NFL

Miami Dolphins
27 :  28
Arizona Cardinals
Carolina Panthers
Carolina Panthers Latest matches
L L W L W L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Sep 7, 2025 - NFL

Jacksonville Jaguars
26 :  10
Carolina Panthers

Jan 5, 2025 - NFL

Atlanta Falcons
38 :  44
Carolina Panthers

Dec 29, 2024 - NFL

Tampa Bay Buccaneers
48 :  14
Carolina Panthers

Dec 22, 2024 - NFL

Carolina Panthers
36 :  30
Arizona Cardinals

Dec 15, 2024 - NFL

Carolina Panthers
14 :  30
Dallas Cowboys

Dec 8, 2024 - NFL

Philadelphia Eagles
22 :  16
Carolina Panthers
L W W L L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Dec 22, 2024 - NFL

Carolina Panthers
36 :  30
Arizona Cardinals

Dec 15, 2024 - NFL

Carolina Panthers
14 :  30
Dallas Cowboys

Nov 24, 2024 - NFL

Carolina Panthers
27 :  30
Kansas City Chiefs

Nov 10, 2024 - NFL

Carolina Panthers
20 :  17
New York Giants

Nov 3, 2024 - NFL

Carolina Panthers
23 :  22
New Orleans Saints

Oct 13, 2024 - NFL

Carolina Panthers
20 :  38
Atlanta Falcons
L L L L W L
Victories

1/6 (17%)

Defeats

5/6 (83%)

Sep 7, 2025 - NFL

Jacksonville Jaguars
26 :  10
Carolina Panthers

Jan 5, 2025 - NFL

Atlanta Falcons
38 :  44
Carolina Panthers

Dec 29, 2024 - NFL

Tampa Bay Buccaneers
48 :  14
Carolina Panthers

Dec 8, 2024 - NFL

Philadelphia Eagles
22 :  16
Carolina Panthers

Oct 27, 2024 - NFL

Denver Broncos
28 :  14
Carolina Panthers

Oct 20, 2024 - NFL

Washington Commanders
40 :  7
Carolina Panthers

Arizona Cardinals against Carolina Panthers : Head to Head (H2H)

Arizona Cardinals

0 %

Carolina Panthers

100 %

Dec 22, 2024 - NFL

Carolina Panthers
36 :  30
Arizona Cardinals

Arizona Cardinals - Carolina Panthers Key Points

  1. Arizona is 5-1 ATS in its last 6 games at home.
  2. Arizona is 2-5 SU in its last 7 games against an opponent in the National Football Conference
  3. Carolina is 2-16 SU in its last 18 games on the road.
  4. Carolina is 1-5 ATS in its last 6 games played in September.

Our Arizona Cardinals vs Carolina Panthers Prediction

Bet on the Cardinals to win and cover -6.5 points against the Panthers, who are 2-16 in their last 18 games on the road. Never mind that Arizona is 1-7 in its last 8 meetings with Carolina. The Cardinals showed in their season-opening game against the Saints that they can hold their ground in the red zone. Kyle Murray will only get better in Week 2 after throwing for 162 yards despite feeling ill the morning before the match. As for Bryce Young, he would have to take his game to another level if he wants to lead his team to an upset on the road. Young covered 154 yards in the first game against the Jaguars, but he still ended up with a quarterback rating of 25.0 after throwing two interceptions.

Barring a meltdown, Arizona should take care of its business against the Panthers. Expect Murray to top his week 1 performance with a more tantalizing stats line against the Carolina defense that is projected to be mediocre this season.

Our betting prediction for Arizona Cardinals vs. the Carolina Panthers: the Cardinals -6.5 points.

Prediction:

 

The Cardinals -6.5 Points

-115
$350 offered for betting!

All tips are fully researched and given in good faith, but profits cannot be guaranteed.

Arizona Cardinals vs Carolina Panthers Picks