Pittsburgh Steelers vs Buffalo Bills Prediction & Picks - NFL

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Pittsburgh Steelers
11/30/25 16:25
Buffalo Bills

Prediction:

 

Buffalo Bills ML

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 by Matt Lowrimore | in NFL Picks

One of the important games on the NFL Week 13 Sunday slate will see the Pittsburgh Steelers take on the Buffalo Bills. Let’s take a look at the match statistics and predictions for this game between the Steelers and the Bills.

Buffalo enters this game with a record of 7-4, having most recently lost to the Houston Texans by a score of 23-19 in Week 12. The Bills’ offense had a total of 326 yards, while its defense allowed 261 yards. Quarterback Josh Allen threw for 253 yards and two interceptions, while running back James Cook III led the team in rushing with 116 yards.

As for Pittsburgh, they enter this game with a record of 6-5, having most recently lost to the Chicago Bears in Week 12 by a score of 31-28. The Steelers’ offense had a total of 345 yards, while its defense allowed 328 yards. Quarterback Mason Rudolph threw for 171 yards, one touchdown, and one interception, while running back Kenneth Gainwell led the team in rushing with 92 yards.

Pittsburgh Steelers vs Buffalo Bills Form

Table

Teams Pts P W L
8 Buffalo Bills
0.706 17 12 5
12 Pittsburgh Steelers
0.588 17 10 7

Pittsburgh Steelers and Buffalo Bills Latest Matches

Pittsburgh Steelers
Pittsburgh Steelers Latest matches
L L W L W L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Nov 23, 2025 - NFL

Chicago Bears
31 :  28
Pittsburgh Steelers

Nov 16, 2025 - NFL

Pittsburgh Steelers
34 :  12
Cincinnati Bengals

Nov 9, 2025 - NFL

Los Angeles Chargers
25 :  10
Pittsburgh Steelers

Nov 2, 2025 - NFL

Pittsburgh Steelers
27 :  20
Indianapolis Colts

Oct 26, 2025 - NFL

Pittsburgh Steelers
25 :  35
Green Bay Packers

Oct 16, 2025 - NFL

Cincinnati Bengals
33 :  31
Pittsburgh Steelers
L W W L W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Nov 16, 2025 - NFL

Pittsburgh Steelers
34 :  12
Cincinnati Bengals

Nov 2, 2025 - NFL

Pittsburgh Steelers
27 :  20
Indianapolis Colts

Oct 26, 2025 - NFL

Pittsburgh Steelers
25 :  35
Green Bay Packers

Oct 12, 2025 - NFL

Pittsburgh Steelers
23 :  9
Cleveland Browns

Sep 28, 2025 - NFL

Pittsburgh Steelers
24 :  21
Minnesota Vikings

Sep 14, 2025 - NFL

Pittsburgh Steelers
17 :  31
Seattle Seahawks
L W W L L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Nov 23, 2025 - NFL

Chicago Bears
31 :  28
Pittsburgh Steelers

Nov 9, 2025 - NFL

Los Angeles Chargers
25 :  10
Pittsburgh Steelers

Oct 16, 2025 - NFL

Cincinnati Bengals
33 :  31
Pittsburgh Steelers

Sep 21, 2025 - NFL

New England Patriots
14 :  21
Pittsburgh Steelers

Sep 7, 2025 - NFL

New York Jets
32 :  34
Pittsburgh Steelers

Jan 11, 2025 - NFL

Baltimore Ravens
28 :  14
Pittsburgh Steelers
Buffalo Bills
Buffalo Bills Latest matches
L W W L W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Nov 20, 2025 - NFL

Houston Texans
23 :  19
Buffalo Bills

Nov 16, 2025 - NFL

Buffalo Bills
44 :  32
Tampa Bay Buccaneers

Nov 9, 2025 - NFL

Miami Dolphins
30 :  13
Buffalo Bills

Nov 2, 2025 - NFL

Buffalo Bills
28 :  21
Kansas City Chiefs

Oct 26, 2025 - NFL

Carolina Panthers
9 :  40
Buffalo Bills

Oct 13, 2025 - NFL

Atlanta Falcons
24 :  14
Buffalo Bills
W W W L W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Nov 16, 2025 - NFL

Buffalo Bills
44 :  32
Tampa Bay Buccaneers

Nov 2, 2025 - NFL

Buffalo Bills
28 :  21
Kansas City Chiefs

Oct 5, 2025 - NFL

Buffalo Bills
20 :  23
New England Patriots

Sep 28, 2025 - NFL

Buffalo Bills
31 :  19
New Orleans Saints

Sep 18, 2025 - NFL

Buffalo Bills
31 :  21
Miami Dolphins

Sep 7, 2025 - NFL

Buffalo Bills
41 :  40
Baltimore Ravens
L W L W L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Nov 20, 2025 - NFL

Houston Texans
23 :  19
Buffalo Bills

Nov 9, 2025 - NFL

Miami Dolphins
30 :  13
Buffalo Bills

Oct 26, 2025 - NFL

Carolina Panthers
9 :  40
Buffalo Bills

Oct 13, 2025 - NFL

Atlanta Falcons
24 :  14
Buffalo Bills

Sep 14, 2025 - NFL

New York Jets
10 :  30
Buffalo Bills

Jan 26, 2025 - NFL

Kansas City Chiefs
32 :  29
Buffalo Bills

Pittsburgh Steelers against Buffalo Bills : Head to Head (H2H)

Pittsburgh Steelers

0 %

Buffalo Bills

100 %

Jan 15, 2024 - NFL

Buffalo Bills
31 :  17
Pittsburgh Steelers
Pittsburgh Steelers vs Buffalo Bills Picks

Pittsburgh Steelers - Buffalo Bills Key Points

  1. The Bills are averaging 28.3 points per game
  2. The Bills are allowing 22.9 points per game
  3. The Steelers are averaging 24.9 points per game
  4. The Steelers are allowing 23.9 points per game

Our Pittsburgh Steelers vs Buffalo Bills Prediction

Buffalo is a small favorite in this game, but still looks to be the best betting option. The Bills have struggled at times this season, having lost to Miami and Houston over the last few weeks. However, they still have one of the better rosters in the NFL.

Pittsburgh, on the other hand, is dealing with multiple injuries, including to their quarterback, Aaron Rodgers. His status is still unknown, so if he is unable to play, Mason Rudolph is the likely option to play as a backup. 

He has never been a viable option at quarterback; therefore, because the Bills seem to be healthier and overall a better team, our Pittsburgh Steelers vs Buffalo Bills prediction is: Buffalo Bills ML.

Prediction:

 

Buffalo Bills ML

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$150 offered for betting!

All tips are fully researched and given in good faith, but profits cannot be guaranteed.