Los Angeles Rams vs Buffalo Bills Prediction & Picks - NFL
USA - NFL
New customers only | Commercial content | 21+ age limit | T&Cs apply
by Travis Pulver in NFL Picks
The Buffalo Bills (3-1, 1-0 Away) will try to stay undefeated on the road this season as they take on the Los Angeles Rams (2-2, 1-1 at Home) on Monday Night Football. Kickoff at SoFi Stadium in Inglewood, CA, is scheduled for 8:15 p.m. EST on ESPN.
Buffalo enters this game fresh off its first loss of the season last week, 29-26 to the New England Patriots. Drake May and the Patriots offense looked shaky the first three weeks of the season but came alive against a struggling Buffalo defense (No. 27 in yards allowed, 372.3 per game; No. 25 in scoring, 26.8 points per game). They took a late lead with a 34-yard touchdown pass from Josh Allen to Keon Coleman, but the defense couldn’t hold on the next drive.
Inconsistency and injuries have been the bigger story for the Rams. Myles Garrett remains out, Aaron Donald is expected to return this week, and Puka Nacua missed Weeks 2 and 3. After struggling against the 49ers in Australia in Week 1, they cruised over the Giants in Week 2, but then gave up 30 points to the Broncos in the second half in Week 3 and lost. While they beat the Eagles last week, the offense played an uneven game and benefited from facing an injury-decimated, struggling Eagles team.
Limited Offer. Currently at DraftKings
Los Angeles Rams vs Buffalo Bills Form
Table
| Teams | Pts | P | W | L |
|---|---|---|---|---|
|
6
|
0.75 | 4 | 3 | 1 |
|
18
|
0.5 | 4 | 2 | 2 |
Los Angeles Rams and Buffalo Bills Latest Matches
3/6 (50%)
3/6 (50%)
Oct 4, 2026 - NFL
Sep 27, 2026 - NFL
Sep 21, 2026 - NFL
Sep 10, 2026 - NFL
Jan 25, 2026 - NFL
Jan 18, 2026 - NFL
5/6 (83%)
1/6 (17%)
Sep 21, 2026 - NFL
Sep 10, 2026 - NFL
Jan 4, 2026 - NFL
Dec 14, 2025 - NFL
Nov 23, 2025 - NFL
Nov 16, 2025 - NFL
3/6 (50%)
3/6 (50%)
Oct 4, 2026 - NFL
Sep 27, 2026 - NFL
Jan 25, 2026 - NFL
Jan 18, 2026 - NFL
Jan 10, 2026 - NFL
Dec 29, 2025 - NFL
4/6 (67%)
2/6 (33%)
Oct 4, 2026 - NFL
Sep 27, 2026 - NFL
Sep 17, 2026 - NFL
Sep 13, 2026 - NFL
Jan 17, 2026 - NFL
Jan 11, 2026 - NFL
4/6 (67%)
2/6 (33%)
Oct 4, 2026 - NFL
Sep 27, 2026 - NFL
Sep 17, 2026 - NFL
Jan 4, 2026 - NFL
Dec 28, 2025 - NFL
Dec 7, 2025 - NFL
5/6 (83%)
1/6 (17%)
Sep 13, 2026 - NFL
Jan 17, 2026 - NFL
Jan 11, 2026 - NFL
Dec 21, 2025 - NFL
Dec 14, 2025 - NFL
Nov 30, 2025 - NFL
Los Angeles Rams against Buffalo Bills : Head to Head (H2H)
50 %
50 %
Dec 8, 2024 - NFL
Sep 8, 2022 - NFL
Los Angeles Rams - Buffalo Bills Key Points
- Buffalo leads the all-time series vs. the Rams 9-6 but lost the last meeting 42-44 in LA (December 8, 2024).
- Josh Allen is tied with Derrick Henry for the league lead in rushing touchdowns, with seven.
- The Rams' defense has surrendered one rushing touchdown to quarterbacks this season.
- Betting Public: 63% of total tickets and 71% of the handle are on the OVER.
Limited Offer. Currently at DraftKings
Our Los Angeles Rams vs Buffalo Bills Prediction
The Rams' defense has been tough to throw on this season (145.5 yards per game allowed), but Josh Allen has rarely had trouble getting the passing game on track against it. In three previous starts, he averaged 300+ yards and 3+ touchdowns per game. So, the Rams may slow him down, but they will not stop him. Mathew Stafford has played the Bills twice since joining the Rams; he had a bad game back in 2022 (three picks), but threw for 320 yards and two scores in 2024. But with how poorly the Bills' defense is playing, I think he is more likely to have a solid game this time.
Both quarterbacks should shine in this game. Yes, the Rams defense has been tough, but Josh Allen is a gamer; he’ll find a way to put points on the board. Because of that, I am not confident in either team to win or cover. But I do expect a high-scoring game.
Our Bills vs. Rams Pick: OVER 54.5
A Welcome Bonus for Los Angeles Rams vs Buffalo Bills!

Looking to place a bet on Los Angeles Rams vs Buffalo Bills? For this NFL match, DraftKings will treat you to an exclusive offer: $200 in bonus bets, no promo code needed! Take advantage while you still can!
All tips are fully researched and given in good faith, but profits cannot be guaranteed.