Los Angeles Rams vs Buffalo Bills Prediction & Picks - NFL

USA - NFL

Los Angeles Rams
10/12/26 20:15
Buffalo Bills

Prediction:

 

OVER 54.5

-118
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 by Travis Pulver in NFL Picks

The Buffalo Bills (3-1, 1-0 Away) will try to stay undefeated on the road this season as they take on the Los Angeles Rams (2-2, 1-1 at Home) on Monday Night Football. Kickoff at SoFi Stadium in Inglewood, CA, is scheduled for 8:15 p.m. EST on ESPN.

Buffalo enters this game fresh off its first loss of the season last week, 29-26 to the New England Patriots. Drake May and the Patriots offense looked shaky the first three weeks of the season but came alive against a struggling Buffalo defense (No. 27 in yards allowed, 372.3 per game; No. 25 in scoring, 26.8 points per game). They took a late lead with a 34-yard touchdown pass from Josh Allen to Keon Coleman, but the defense couldn’t hold on the next drive.

Inconsistency and injuries have been the bigger story for the Rams. Myles Garrett remains out, Aaron Donald is expected to return this week, and Puka Nacua missed Weeks 2 and 3. After struggling against the 49ers in Australia in Week 1, they cruised over the Giants in Week 2, but then gave up 30 points to the Broncos in the second half in Week 3 and lost. While they beat the Eagles last week, the offense played an uneven game and benefited from facing an injury-decimated, struggling Eagles team.

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Los Angeles Rams vs Buffalo Bills Form

Table

Teams Pts P W L
6 Buffalo Bills
0.75 4 3 1
18 Los Angeles Rams
0.5 4 2 2

Los Angeles Rams and Buffalo Bills Latest Matches

Los Angeles Rams
Los Angeles Rams Latest matches
W L L W L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Oct 4, 2026 - NFL

Philadelphia Eagles
20 :  24
Los Angeles Rams

Sep 27, 2026 - NFL

Denver Broncos
30 :  26
Los Angeles Rams

Sep 21, 2026 - NFL

Los Angeles Rams
28 :  6
New York Giants

Sep 10, 2026 - NFL

Los Angeles Rams
7 :  27
San Francisco 49ers

Jan 25, 2026 - NFL

Seattle Seahawks
31 :  27
Los Angeles Rams

Jan 18, 2026 - NFL

Chicago Bears
17 :  20
Los Angeles Rams
W W W W L W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Sep 21, 2026 - NFL

Los Angeles Rams
28 :  6
New York Giants

Sep 10, 2026 - NFL

Los Angeles Rams
7 :  27
San Francisco 49ers

Jan 4, 2026 - NFL

Los Angeles Rams
37 :  20
Arizona Cardinals

Dec 14, 2025 - NFL

Los Angeles Rams
41 :  34
Detroit Lions

Nov 23, 2025 - NFL

Los Angeles Rams
34 :  7
Tampa Bay Buccaneers

Nov 16, 2025 - NFL

Los Angeles Rams
21 :  19
Seattle Seahawks
L W W L L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Oct 4, 2026 - NFL

Philadelphia Eagles
20 :  24
Los Angeles Rams

Sep 27, 2026 - NFL

Denver Broncos
30 :  26
Los Angeles Rams

Jan 25, 2026 - NFL

Seattle Seahawks
31 :  27
Los Angeles Rams

Jan 18, 2026 - NFL

Chicago Bears
17 :  20
Los Angeles Rams

Jan 10, 2026 - NFL

Carolina Panthers
31 :  34
Los Angeles Rams

Dec 29, 2025 - NFL

Atlanta Falcons
27 :  24
Los Angeles Rams
Buffalo Bills
Buffalo Bills Latest matches
W L W W W L
Victories

4/6 (67%)

Defeats

2/6 (33%)

Oct 4, 2026 - NFL

Buffalo Bills
26 :  29
New England Patriots

Sep 27, 2026 - NFL

Buffalo Bills
24 :  16
Los Angeles Chargers

Sep 17, 2026 - NFL

Buffalo Bills
41 :  31
Detroit Lions

Sep 13, 2026 - NFL

Houston Texans
31 :  36
Buffalo Bills

Jan 17, 2026 - NFL

Denver Broncos
33 :  30
Buffalo Bills

Jan 11, 2026 - NFL

Jacksonville Jaguars
24 :  27
Buffalo Bills
W L W W W L
Victories

4/6 (67%)

Defeats

2/6 (33%)

Oct 4, 2026 - NFL

Buffalo Bills
26 :  29
New England Patriots

Sep 27, 2026 - NFL

Buffalo Bills
24 :  16
Los Angeles Chargers

Sep 17, 2026 - NFL

Buffalo Bills
41 :  31
Detroit Lions

Jan 4, 2026 - NFL

Buffalo Bills
35 :  8
New York Jets

Dec 28, 2025 - NFL

Buffalo Bills
12 :  13
Philadelphia Eagles

Dec 7, 2025 - NFL

Buffalo Bills
39 :  34
Cincinnati Bengals
W W W W L W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Sep 13, 2026 - NFL

Houston Texans
31 :  36
Buffalo Bills

Jan 17, 2026 - NFL

Denver Broncos
33 :  30
Buffalo Bills

Jan 11, 2026 - NFL

Jacksonville Jaguars
24 :  27
Buffalo Bills

Dec 21, 2025 - NFL

Cleveland Browns
20 :  23
Buffalo Bills

Dec 14, 2025 - NFL

New England Patriots
31 :  35
Buffalo Bills

Nov 30, 2025 - NFL

Pittsburgh Steelers
7 :  26
Buffalo Bills

Los Angeles Rams against Buffalo Bills : Head to Head (H2H)

Los Angeles Rams

50 %

Buffalo Bills

50 %

Dec 8, 2024 - NFL

Los Angeles Rams
44 :  42
Buffalo Bills

Sep 8, 2022 - NFL

Los Angeles Rams
10 :  31
Buffalo Bills
Los Angeles Rams vs Buffalo Bills Picks

Los Angeles Rams - Buffalo Bills Key Points

  1. Buffalo leads the all-time series vs. the Rams 9-6 but lost the last meeting 42-44 in LA (December 8, 2024).
  2. Josh Allen is tied with Derrick Henry for the league lead in rushing touchdowns, with seven.
  3. The Rams' defense has surrendered one rushing touchdown to quarterbacks this season.
  4. Betting Public: 63% of total tickets and 71% of the handle are on the OVER.
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Our Los Angeles Rams vs Buffalo Bills Prediction

The Rams' defense has been tough to throw on this season (145.5 yards per game allowed), but Josh Allen has rarely had trouble getting the passing game on track against it. In three previous starts, he averaged 300+ yards and 3+ touchdowns per game. So, the Rams may slow him down, but they will not stop him. Mathew Stafford has played the Bills twice since joining the Rams; he had a bad game back in 2022 (three picks), but threw for 320 yards and two scores in 2024. But with how poorly the Bills' defense is playing, I think he is more likely to have a solid game this time.

Both quarterbacks should shine in this game. Yes, the Rams defense has been tough, but Josh Allen is a gamer; he’ll find a way to put points on the board. Because of that, I am not confident in either team to win or cover. But I do expect a high-scoring game.

Our Bills vs. Rams Pick: OVER 54.5

Prediction:

 

OVER 54.5

-118
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All tips are fully researched and given in good faith, but profits cannot be guaranteed.