Iowa State Cyclones vs BYU Cougars Prediction & Picks - NCAA

USA - NCAA

Iowa State Cyclones
10/25/25 15:30
BYU Cougars

Prediction:

 

BYU Cougars +3.5 Alternate Spread

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 by Matt Lowrimore | in NCAA Picks

One of the more intriguing games on the Week 9 college football slate will see the 11th-ranked BYU Cougars and the Iowa State Cyclones in the Big 12. Let’s take a look at the match statistics and predictions for this game between the Cougars and the Cyclones.

BYU enters this game with a record of 7-0 and 4-0 in the Big 12. The Cougars most recently beat the Utah Utes in Week 8 by a score of 24-21. BYU’s offense had a total of 368 yards, while its defense allowed 470 yards. Quarterback Bear Bachmeier threw for 166 yards, while running back LJ Martin led the team in rushing with 122 yards.

As for Iowa State, they enter this game with a record of 5-2 and 2-2 in the Big 12. The Cyclones most recently lost to the Colorado Buffaloes in Week 7 by a score of 24-17. Iowa State’s offense had a total of 441 yards, while its defense allowed 395 yards. Quarterback Rocco Becht threw for 205 yards and one interception, while running back Abu Sama III led the team in rushing with 177 yards and two touchdowns.

Iowa State Cyclones vs BYU Cougars Form

Table

Iowa State Cyclones and BYU Cougars Latest Matches

Iowa State Cyclones
Iowa State Cyclones Latest matches
W W W W L
Victories

4/5 (80%)

Defeats

1/5 (20%)

Oct 4, 2025 - NCAA

Cincinnati Bearcats
38 :  30
Iowa State Cyclones

Sep 27, 2025 - NCAA

Iowa State Cyclones
39 :  14
Arizona Wildcats

Sep 6, 2025 - NCAA

Iowa State Cyclones
16 :  13
Iowa Hawkeyes

Aug 23, 2025 - NCAA

Kansas State Wildcats
21 :  24
Iowa State Cyclones

Oct 19, 2024 - NCAA

Iowa State Cyclones
38 :  35
UCF Knights
W W W
Victories

3/3 (100%)

Defeats

0/3 (0%)

Sep 27, 2025 - NCAA

Iowa State Cyclones
39 :  14
Arizona Wildcats

Sep 6, 2025 - NCAA

Iowa State Cyclones
16 :  13
Iowa Hawkeyes

Oct 19, 2024 - NCAA

Iowa State Cyclones
38 :  35
UCF Knights
W L
Victories

1/2 (50%)

Defeats

1/2 (50%)

Oct 4, 2025 - NCAA

Cincinnati Bearcats
38 :  30
Iowa State Cyclones

Aug 23, 2025 - NCAA

Kansas State Wildcats
21 :  24
Iowa State Cyclones
BYU Cougars
BYU Cougars Latest matches
W W W W
Victories

4/4 (100%)

Defeats

0/4 (0%)

Oct 18, 2025 - NCAA

BYU Cougars
24 :  21
Utah Utes

Oct 11, 2025 - NCAA

Arizona Wildcats
27 :  33
BYU Cougars

Oct 3, 2025 - NCAA

BYU Cougars
38 :  24
West Virginia Mountaineers

Sep 6, 2024 - NCAA

SMU Mustangs
15 :  18
BYU Cougars
W W
Victories

2/2 (100%)

Defeats

0/2 (0%)

Oct 18, 2025 - NCAA

BYU Cougars
24 :  21
Utah Utes

Oct 3, 2025 - NCAA

BYU Cougars
38 :  24
West Virginia Mountaineers
W W
Victories

2/2 (100%)

Defeats

0/2 (0%)

Oct 11, 2025 - NCAA

Arizona Wildcats
27 :  33
BYU Cougars

Sep 6, 2024 - NCAA

SMU Mustangs
15 :  18
BYU Cougars
Iowa State Cyclones vs BYU Cougars Picks

Iowa State Cyclones - BYU Cougars Key Points

  1. BYU is 2-2 ATS vs the Big 12
  2. BYU is averaging 29.8 points per game vs the Big 12
  3. Iowa State is 2-2 ATS vs the Big 12
  4. Iowa State is averaging 27.5 points per game vs the Big 12

Our Iowa State Cyclones vs BYU Cougars Prediction

BYU is one of the few undefeated teams left in the country, and once again, they find themselves an underdog this week against Iowa State. The Cougars have been nothing but solid this season, averaging 29.8 points per game against the Big 12 and winning four conference games by an average margin of 6.5 points per game. 

Iowa State, on the other hand, is close to playing themselves out of the Big 12 championship game and the College Football Playoffs, as they have lost two games in a row. The loss to Colorado was especially alarming as the Buffaloes are a below .500 team.

The Cyclones are coming off a bye and get this game at home; however, BYU has continued to show their resiliency. For that reason, our BYU Cougars vs Iowa State Cyclones prediction is: BYU Cougars +3.5 Alternate Spread.

Prediction:

 

BYU Cougars +3.5 Alternate Spread

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All tips are fully researched and given in good faith, but profits cannot be guaranteed.