Boston Red Sox vs Cleveland Guardians Prediction & Picks - MLB

USA - MLB

Boston Red Sox
4/27/25 13:40
Cleveland Guardians

Prediction:

 

UNDER 7.5

-102
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 by Travis Pulver | in MLB Picks

The Boston Red Sox will close out a weekend road trip to Cleveland today with the final game of their weekend series vs. the Indians at Progressive Field in Cleveland, OH. Fans can follow the action once the game gets underway at 1:40 p.m. EST.

With Friday’s game getting postponed, the Red Sox and Indians played a doubleheader Saturday. Cleveland won the first game 5-4. Boston got on top early with three runs in the top of the first, but the lead did not last with the Indians scoring four in the bottom of the inning. The Red Sox tied the game up with a run in the third, but then the Indians scored the go-ahead run in the sixth. In the second game, the Boston lineup built an early lead with six runs off Cleveland starter Doug Nikhazy within the first three innings. They went on to win 7-3.

Boston will give the ball to Brayan Bello to start the day. Bello got the win in his only other start,  vs. Seattle, on Tuesday (five innings, four hits, one earned run, three walks, and three strikeouts). Cleveland will go with Logan Allen on the mound. The young lefty is 1-1 on the season in four starts with a 2.11 ERA.

Boston Red Sox vs Cleveland Guardians Form

Table

Teams % P W L
9
Cleveland Guardians
Cleveland Guardians
0.567 30 17 13
13
Boston Red Sox
Boston Red Sox
0.531 32 17 15

Boston Red Sox and Cleveland Guardians Latest Matches

Boston Red Sox
Boston Red Sox Latest matches
W W L L W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Apr 26, 2025 - MLB

Boston Red Sox
7 :  3
Cleveland Guardians

Apr 26, 2025 - MLB

Boston Red Sox
4 :  5
Cleveland Guardians

Apr 24, 2025 - MLB

Seattle Mariners
4 :  3
Boston Red Sox

Apr 23, 2025 - MLB

Seattle Mariners
8 :  5
Boston Red Sox

Apr 22, 2025 - MLB

Seattle Mariners
3 :  8
Boston Red Sox

Apr 21, 2025 - MLB

Chicago White Sox
2 :  4
Boston Red Sox
W L W W L L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Apr 24, 2025 - MLB

Seattle Mariners
4 :  3
Boston Red Sox

Apr 23, 2025 - MLB

Seattle Mariners
8 :  5
Boston Red Sox

Apr 22, 2025 - MLB

Seattle Mariners
3 :  8
Boston Red Sox

Apr 21, 2025 - MLB

Chicago White Sox
2 :  4
Boston Red Sox

Apr 20, 2025 - MLB

Chicago White Sox
8 :  4
Boston Red Sox

Apr 19, 2025 - MLB

Chicago White Sox
3 :  4
Boston Red Sox
W L W W L W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Apr 26, 2025 - MLB

Boston Red Sox
7 :  3
Cleveland Guardians

Apr 26, 2025 - MLB

Boston Red Sox
4 :  5
Cleveland Guardians

Apr 16, 2025 - MLB

Boston Red Sox
1 :  0
Tampa Bay Rays

Apr 15, 2025 - MLB

Boston Red Sox
7 :  4
Tampa Bay Rays

Apr 14, 2025 - MLB

Boston Red Sox
1 :  16
Tampa Bay Rays

Apr 13, 2025 - MLB

Boston Red Sox
3 :  1
Chicago White Sox
Cleveland Guardians
Cleveland Guardians Latest matches
W W W L L W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Apr 26, 2025 - MLB

Boston Red Sox
7 :  3
Cleveland Guardians

Apr 26, 2025 - MLB

Boston Red Sox
4 :  5
Cleveland Guardians

Apr 23, 2025 - MLB

New York Yankees
5 :  1
Cleveland Guardians

Apr 22, 2025 - MLB

New York Yankees
2 :  3
Cleveland Guardians

Apr 21, 2025 - MLB

New York Yankees
4 :  6
Cleveland Guardians

Apr 20, 2025 - MLB

Cleveland Guardians
5 :  4
Pittsburgh Pirates
L W W L W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Apr 26, 2025 - MLB

Boston Red Sox
7 :  3
Cleveland Guardians

Apr 26, 2025 - MLB

Boston Red Sox
4 :  5
Cleveland Guardians

Apr 23, 2025 - MLB

New York Yankees
5 :  1
Cleveland Guardians

Apr 22, 2025 - MLB

New York Yankees
2 :  3
Cleveland Guardians

Apr 21, 2025 - MLB

New York Yankees
4 :  6
Cleveland Guardians

Apr 13, 2025 - MLB

Kansas City Royals
4 :  2
Cleveland Guardians
W L L W W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Apr 20, 2025 - MLB

Cleveland Guardians
5 :  4
Pittsburgh Pirates

Apr 19, 2025 - MLB

Cleveland Guardians
3 :  0
Pittsburgh Pirates

Apr 18, 2025 - MLB

Cleveland Guardians
10 :  7
Pittsburgh Pirates

Apr 17, 2025 - MLB

Cleveland Guardians
2 :  6
Baltimore Orioles

Apr 16, 2025 - MLB

Cleveland Guardians
1 :  9
Baltimore Orioles

Apr 15, 2025 - MLB

Cleveland Guardians
6 :  3
Baltimore Orioles

Boston Red Sox against Cleveland Guardians : Head to Head (H2H)

Boston Red Sox

33 %

Cleveland Guardians

67 %

Apr 26, 2025 - MLB

Boston Red Sox
7 :  3
Cleveland Guardians

Apr 26, 2025 - MLB

Boston Red Sox
4 :  5
Cleveland Guardians

Apr 25, 2024 - MLB

Boston Red Sox
4 :  6
Cleveland Guardians

Apr 24, 2024 - MLB

Boston Red Sox
8 :  0
Cleveland Guardians

Apr 23, 2024 - MLB

Boston Red Sox
1 :  4
Cleveland Guardians

Apr 18, 2024 - MLB

Cleveland Guardians
5 :  4
Boston Red Sox

Boston Red Sox - Cleveland Guardians Key Points

  1. Cleveland leads the all-time series vs. Boston 1073-1010-8.
  2. Cleveland won the season series last year, 5-2.
  3. The Red Sox are 7-8 away from home while the Indians are 8-3 at home.
  4. Betting Splits: 50% of moneyline tickets are on each team, but 82% of the handle is on Boston.

Our Boston Red Sox vs Cleveland Guardians Prediction

I’m guessing the public is all over the OVER (7.5 runs) since both games yesterday went over. But both starting pitchers are looking good; Bello gave up one run in his only start, and Allen has given up one across his last three starts. My only concern about taking the UNDER is that Boston’s pen has a 4.12 ERA relative to a 3.12 ERA for Cleveland. But the Indians are only hitting .236 over the last week (Boston-- .239 BA).

Our Red Sox vs. Indians Pick: UNDER 7.5

Prediction:

 

UNDER 7.5

-102
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Boston Red Sox vs Cleveland Guardians Picks