Arizona Diamondbacks vs Athletics Prediction & Picks - MLB

On the mound for Oakland is right-hander Jack Perkins, who has appeared in multiple games this season but is still searching for consistency. In limited action—19.2 innings—he’s posted a solid 2.75 ERA but has yet to record a win. While the ERA looks promising, Perkins has not faced many high-powered lineups, and his peripheral stats suggest he’s been walking a fine line with control issues and limited strikeout potential. This outing will be a good test of whether he can handle a more experienced National League offense.

Arizona counters with Eduardo Rodriguez, a veteran left-hander who has struggled in recent outings. Rodriguez has allowed four or more earned runs in three of his last four starts, including five runs surrendered in his most recent appearance. His command and efficiency have been erratic, and opposing teams have taken advantage of missed spots and elevated pitches. Still, Rodriguez brings more big-league experience to the table than Perkins, and he'll look to reset against a relatively unproven A’s lineup.

The key to this game will likely be which struggling starter settles in more effectively. Rodriguez has been shaky, but the Diamondbacks’ lineup has the tools to back him up, especially after their strong offensive showing in Game 1. With hitters like Ketel Marte, Christian Walker, and Corbin Carroll providing consistent power and speed, Arizona has a clear edge at the plate. They’ve shown they can break out offensively, and against a young pitcher like Perkins, this could be another opportunity to build confidence.

Oakland’s recent surge makes them a dangerous underdog, especially at home, but their offense remains inconsistent and ranks near the bottom of the league in most categories, including home runs and batting average. If Rodriguez can limit damage early and the D-Backs’ bats stay warm, Arizona has the upper hand.

Given the matchup of a veteran trying to bounce back versus a rookie still finding his footing, and considering Arizona’s lineup advantage, the Diamondbacks are the safer pick to take Game 2 and possibly clinch the series. A victory here could mark the beginning of a much-needed rebound for a team with postseason aspirations still within reach. Our prediction for Athletics vs. Arizona Diamondbacks: Diamondbacks to win.