CF America vs Pumas UNAM Prediction & Picks - Liga MX

Prediction published on 9/27/25, 7:59 PM  by Carlos Zabala | Modified on 9/28/25 at 1:10 AM in Liga MX Picks

América earned a valuable victory against Atlético San Luis in Potosí. Although América started as a -142 favorite, it was a very close game, and Atlético San Luis actually had the clearest scoring chances.

In América's last match, Alex Zendejas came off the bench before the first half, replacing Rodrigo Aguirre, who had a poor showing. Zendejas continued his tremendous scoring streak; he took advantage of a headed pass as the game ended, drove into the box, cut inside, and scored the goal in the 88th minute, celebrating with explosive style. Zendejas, with both the U.S. national team and América, has contributed at least one goal in each of his last four matches.

América's next opponent will be Pumas, who are coming off their third Liga MX loss of the season when they lost to Juárez on the last matchday. There, Estupiñán opened the scoring for "Los Potros"; VAR ruled out a goal for the university team, but Martínez Ayala temporarily tied the game. Juárez then committed an unnecessarily harsh challenge that resulted in his expulsion. From that same foul, Juárez scored the goal with a cross into the box that put them ahead and would prove an insurmountable advantage for Pumas.