St. Louis Cardinals vs Cleveland Guardians Prediction & Picks - MLB

USA - MLB

St. Louis Cardinals
6/29/25 12:05
Cleveland Guardians

Prediction:

 

St. Louis Cardinals wins the match

-127
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 by Carlos Zabala in MLB Picks

The Cardinals haven't lost a series since the second week of June, and after beating the Guardians 5-0 in Game 1 of their series in Cleveland, they showed their ability to hit in rallies to close out a 5-run deficit in Game 2, with the Cards scoring 5 runs of their own in the top of the sixth inning. In that key inning of Saturday's Guards-Cards game, Gorman, Scott, Donovan, and Winn all managed to drive in runs. The Cardinals won 6-9 as the betting underdogs, and Helsley closed the door with his 16th save of the season.

The Cardinals-Guardians series finale on Sunday will be played at noon in Cleveland, the first game of the Sunday schedule. Matthew Liberatore will be the Cards' starting pitcher with a 3.96 ERA, and Logan Allen will be the Guardians' starter with a 5-5 record and a 4.25 ERA.

St. Louis Cardinals vs Cleveland Guardians Form

Table

Teams % P W L
11
St. Louis Cardinals
St. Louis Cardinals
0.548 84 46 38
18
Cleveland Guardians
Cleveland Guardians
0.494 81 40 41

St. Louis Cardinals and Cleveland Guardians Latest Matches

St. Louis Cardinals
St. Louis Cardinals Latest matches
W W L L W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Jun 28, 2025 - MLB

St. Louis Cardinals
9 :  6
Cleveland Guardians

Jun 27, 2025 - MLB

St. Louis Cardinals
5 :  0
Cleveland Guardians

Jun 26, 2025 - MLB

Chicago Cubs
3 :  0
St. Louis Cardinals

Jun 25, 2025 - MLB

Chicago Cubs
8 :  0
St. Louis Cardinals

Jun 24, 2025 - MLB

Chicago Cubs
7 :  8
St. Louis Cardinals

Jun 23, 2025 - MLB

Chicago Cubs
2 :  8
St. Louis Cardinals
W L W W L L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Jun 26, 2025 - MLB

Chicago Cubs
3 :  0
St. Louis Cardinals

Jun 25, 2025 - MLB

Chicago Cubs
8 :  0
St. Louis Cardinals

Jun 24, 2025 - MLB

Chicago Cubs
7 :  8
St. Louis Cardinals

Jun 23, 2025 - MLB

Chicago Cubs
2 :  8
St. Louis Cardinals

Jun 22, 2025 - MLB

Cincinnati Reds
4 :  1
St. Louis Cardinals

Jun 21, 2025 - MLB

Cincinnati Reds
5 :  6
St. Louis Cardinals
L W W W W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Jun 28, 2025 - MLB

St. Louis Cardinals
9 :  6
Cleveland Guardians

Jun 27, 2025 - MLB

St. Louis Cardinals
5 :  0
Cleveland Guardians

Jun 19, 2025 - MLB

St. Louis Cardinals
8 :  6
Chicago White Sox

Jun 19, 2025 - MLB

St. Louis Cardinals
5 :  4
Chicago White Sox

Jun 17, 2025 - MLB

St. Louis Cardinals
12 :  2
Chicago White Sox

Jun 15, 2025 - MLB

St. Louis Cardinals
2 :  3
Milwaukee Brewers
Cleveland Guardians
Cleveland Guardians Latest matches
W L W L L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Jun 28, 2025 - MLB

St. Louis Cardinals
9 :  6
Cleveland Guardians

Jun 27, 2025 - MLB

St. Louis Cardinals
5 :  0
Cleveland Guardians

Jun 26, 2025 - MLB

Toronto Blue Jays
6 :  0
Cleveland Guardians

Jun 25, 2025 - MLB

Toronto Blue Jays
4 :  5
Cleveland Guardians

Jun 24, 2025 - MLB

Toronto Blue Jays
10 :  6
Cleveland Guardians

Jun 22, 2025 - MLB

Cleveland Guardians
3 :  0
Athletics
W L W L L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Jun 28, 2025 - MLB

St. Louis Cardinals
9 :  6
Cleveland Guardians

Jun 27, 2025 - MLB

St. Louis Cardinals
5 :  0
Cleveland Guardians

Jun 26, 2025 - MLB

Toronto Blue Jays
6 :  0
Cleveland Guardians

Jun 25, 2025 - MLB

Toronto Blue Jays
4 :  5
Cleveland Guardians

Jun 24, 2025 - MLB

Toronto Blue Jays
10 :  6
Cleveland Guardians

Jun 11, 2025 - MLB

Cincinnati Reds
2 :  11
Cleveland Guardians
W W L L W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Jun 22, 2025 - MLB

Cleveland Guardians
3 :  0
Athletics

Jun 21, 2025 - MLB

Cleveland Guardians
4 :  2
Athletics

Jun 20, 2025 - MLB

Cleveland Guardians
1 :  5
Athletics

Jun 19, 2025 - MLB

Cleveland Guardians
1 :  2
San Francisco Giants

Jun 18, 2025 - MLB

Cleveland Guardians
4 :  2
San Francisco Giants

Jun 17, 2025 - MLB

Cleveland Guardians
3 :  2
San Francisco Giants

St. Louis Cardinals against Cleveland Guardians : Head to Head (H2H)

St. Louis Cardinals

83 %

Cleveland Guardians

17 %

Jun 28, 2025 - MLB

St. Louis Cardinals
9 :  6
Cleveland Guardians

Jun 27, 2025 - MLB

St. Louis Cardinals
5 :  0
Cleveland Guardians

Sep 22, 2024 - MLB

Cleveland Guardians
1 :  2
St. Louis Cardinals

Sep 21, 2024 - MLB

Cleveland Guardians
5 :  6
St. Louis Cardinals

Sep 20, 2024 - MLB

Cleveland Guardians
5 :  1
St. Louis Cardinals

Aug 30, 2020 - MLB

Cleveland Guardians
2 :  7
St. Louis Cardinals

St. Louis Cardinals - Cleveland Guardians Key Points

  1. The Guardians have the second-fewest hits per game in MLB at 7.4
  2. Cardinals' K/9 ratio second-worst in MLB at 7.34
  3. Cardinals have won 7 of their last 10 games
  4. Cardinals average 8.5 hits per game on the road in 2025

Our St. Louis Cardinals vs Cleveland Guardians Prediction

Liberatore put together two quality outings in his last two appearances with the Cardinals, one where he allowed only 2 ER against the White Sox and another where he pitched 7 innings, again allowing only 2 ER against the Cubs. This was a strong moment for the Cardinals' left-hander, but not as strong for Logan Allen, who allowed 8 hits in 5.2 innings against the Blue Jays. Our prediction for Cardinals vs Guardians is: Cardinals ML.

Prediction:

 

St. Louis Cardinals wins the match

-127
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St. Louis Cardinals vs Cleveland Guardians Picks