Pittsburgh Pirates vs St. Louis Cardinals Prediction & Picks - MLB

USA - MLB

Pittsburgh Pirates
5/6/25 19:45
St. Louis Cardinals

Prediction:

 

Paul Skenes 7+ Strikeouts

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 by Lou Aguila in MLB Picks

Pittsburgh Pirates’ ace Paul Skenes will take the field on Tuesday against the St. Louis Cardinals at Busch Stadium.

The Pirates have lost their last 5 games and 8 of their last six games to stay in the bottom of the National League Central with a 12-24 record. Pittsburgh falls in the bottom quadrant of both the batting and pitching metrics, batting .223 (27th) with 117 runs (27th) and pitching a 4.33 ERA (23rd). Paul Skenes, the bright spot in the Pirates down season, is set to pitch on Tuesday against the Cardinals.

Speaking of Cardinals, St. Louis also found themselves fourth in the NL Central with a 17-19 record after over a month of major league baseball. Unlike the Pirates though, the Cardinals’ batting numbers are elite as they rank second in batting average (.261) and 11th in total runs. As for the pitching, they have the second worst ERA in baseball at 4.28.

Pittsburgh Pirates vs St. Louis Cardinals Form

Table

Teams % P W L
19
St. Louis Cardinals
St. Louis Cardinals
0.472 36 17 19
28
Pittsburgh Pirates
Pittsburgh Pirates
0.333 36 12 24

Pittsburgh Pirates and St. Louis Cardinals Latest Matches

Pittsburgh Pirates
Pittsburgh Pirates Latest matches
W L L L L L
Victories

1/6 (17%)

Defeats

5/6 (83%)

May 5, 2025 - MLB

Pittsburgh Pirates
3 :  6
St. Louis Cardinals

May 4, 2025 - MLB

San Diego Padres
4 :  0
Pittsburgh Pirates

May 3, 2025 - MLB

San Diego Padres
2 :  1
Pittsburgh Pirates

May 2, 2025 - MLB

San Diego Padres
9 :  4
Pittsburgh Pirates

May 1, 2025 - MLB

Chicago Cubs
8 :  3
Pittsburgh Pirates

Apr 30, 2025 - MLB

Chicago Cubs
3 :  4
Pittsburgh Pirates
L W L L L L
Victories

1/6 (17%)

Defeats

5/6 (83%)

May 4, 2025 - MLB

San Diego Padres
4 :  0
Pittsburgh Pirates

May 3, 2025 - MLB

San Diego Padres
2 :  1
Pittsburgh Pirates

May 2, 2025 - MLB

San Diego Padres
9 :  4
Pittsburgh Pirates

May 1, 2025 - MLB

Chicago Cubs
8 :  3
Pittsburgh Pirates

Apr 30, 2025 - MLB

Chicago Cubs
3 :  4
Pittsburgh Pirates

Apr 29, 2025 - MLB

Chicago Cubs
9 :  0
Pittsburgh Pirates
W L W L L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

May 5, 2025 - MLB

Pittsburgh Pirates
3 :  6
St. Louis Cardinals

Apr 27, 2025 - MLB

Pittsburgh Pirates
2 :  9
Los Angeles Dodgers

Apr 26, 2025 - MLB

Pittsburgh Pirates
4 :  8
Los Angeles Dodgers

Apr 25, 2025 - MLB

Pittsburgh Pirates
3 :  0
Los Angeles Dodgers

Apr 24, 2025 - MLB

Pittsburgh Pirates
3 :  4
Los Angeles Angels

Apr 23, 2025 - MLB

Pittsburgh Pirates
3 :  0
Los Angeles Angels
St. Louis Cardinals
St. Louis Cardinals Latest matches
W L L W W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

May 5, 2025 - MLB

Pittsburgh Pirates
3 :  6
St. Louis Cardinals

May 4, 2025 - MLB

New York Mets
4 :  5
St. Louis Cardinals

May 4, 2025 - MLB

New York Mets
5 :  6
St. Louis Cardinals

May 2, 2025 - MLB

New York Mets
9 :  3
St. Louis Cardinals

May 1, 2025 - MLB

St. Louis Cardinals
1 :  9
Cincinnati Reds

Apr 30, 2025 - MLB

St. Louis Cardinals
9 :  1
Cincinnati Reds
W L L W W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

May 5, 2025 - MLB

Pittsburgh Pirates
3 :  6
St. Louis Cardinals

May 4, 2025 - MLB

New York Mets
4 :  5
St. Louis Cardinals

May 4, 2025 - MLB

New York Mets
5 :  6
St. Louis Cardinals

May 2, 2025 - MLB

New York Mets
9 :  3
St. Louis Cardinals

Apr 27, 2025 - MLB

Milwaukee Brewers
7 :  1
St. Louis Cardinals

Apr 26, 2025 - MLB

Milwaukee Brewers
5 :  6
St. Louis Cardinals
W L L W W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

May 1, 2025 - MLB

St. Louis Cardinals
1 :  9
Cincinnati Reds

Apr 30, 2025 - MLB

St. Louis Cardinals
9 :  1
Cincinnati Reds

Apr 30, 2025 - MLB

St. Louis Cardinals
6 :  0
Cincinnati Reds

Apr 28, 2025 - MLB

St. Louis Cardinals
1 :  3
Cincinnati Reds

Apr 23, 2025 - MLB

St. Louis Cardinals
1 :  4
Atlanta Braves

Apr 22, 2025 - MLB

St. Louis Cardinals
10 :  4
Atlanta Braves

Pittsburgh Pirates against St. Louis Cardinals : Head to Head (H2H)

Pittsburgh Pirates

50 %

St. Louis Cardinals

50 %

May 5, 2025 - MLB

Pittsburgh Pirates
3 :  6
St. Louis Cardinals

Apr 9, 2025 - MLB

St. Louis Cardinals
1 :  2
Pittsburgh Pirates

Apr 8, 2025 - MLB

St. Louis Cardinals
5 :  3
Pittsburgh Pirates

Apr 7, 2025 - MLB

St. Louis Cardinals
4 :  8
Pittsburgh Pirates

Sep 19, 2024 - MLB

Pittsburgh Pirates
3 :  2
St. Louis Cardinals

Sep 18, 2024 - MLB

Pittsburgh Pirates
5 :  10
St. Louis Cardinals

Pittsburgh Pirates - St. Louis Cardinals Key Points

  1. Paul Skenes is 3-3 with a 2.74 ERA.
  2. Paul Skenes allowed 3 hits in 5.0 innings in an 3-8 loss to the Chicago Cubs in his last start.
  3. Paul Skenes allowed 5 runs in 6.0 innings in his last start vs. the Cardinals.
  4. Paul Skenes averages 5.6 strikeouts per game this season.

Our Pittsburgh Pirates vs St. Louis Cardinals Prediction

Fearless Forecast: Paul Skenes fans 8 batters against the Cardinals.

I am expecting a stronger and sharper Paul Skenes in his second face-off with the Cardinals this season. Skenes struck out seven batters but allowed five earned runs in the Pirates' 3-5 loss to St. Louis on April 8. A pitcher as good Skenes isn’t going to commit the same mistakes twice. Surprisingly, Skenes has pitched better on the road this season than at home. In 3 games play on the road, Skene is 2-0 with a 0.96 ERA and 22 strikeouts. I don’t have a concrete answer as to why he pitches better on the road, but I assume that Skenes is playing with a chip on his shoulder in these games. Our betting prediction for St. Louis Cardinals vs. Pittsburgh Pirates: Paul Skenes 7+ Strikeouts.

Prediction:

 

Paul Skenes 7+ Strikeouts

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Pittsburgh Pirates vs St. Louis Cardinals Picks