New York Yankees vs St. Louis Cardinals Prediction & Picks - MLB

Prediction published on 8/17/25, 12:01 PM  by Travis Pulver | Modified on 8/27/25 at 10:55 AM in MLB Picks

The New York Yankees will go for the sweep today vs. the Cardinals in St. Louis, MO, at Busch Stadium. Fans can follow the action when this interleague contest gets underway at 2:15 p.m. EST.

New York has had some issues since the break, but things may be coming together. With a 4-3 over the Cardinals on Friday and a 12-8 victory yesterday, the Bronx Bombers have won four of their last five to improve to 13-14 since the break. Will Warren will start the day on the mound for the Yankees. He has gone 7-5 this season in 25 starts with a 4.34 ERA, 1.37 WHIP, and .240 OBA. However, he has had some issues on the road, where he is 1-2 in 12 starts with a 6.48 ERA and .284 OBA. He recorded a shutout in his last road start (vs. Texas, Aug. 5) but got shelled in the one prior to it (vs. Atlanta, July 19; 3 2/3 innings, five hits, five runs, two home runs). As for the Cardinals, they’ll start Miles Mikolas. Mikolas is 6-9 in 23 starts with a 4.97 ERA, 1.28 WHIP, and .269 OBA. But he has pitched better from home (3.53 ERA, 3-4 in 11 starts, .228 OBA).