Los Angeles Rams vs San Francisco 49ers Prediction & Picks - NFL

Prediction published on 11/9/25, 1:16 PM  by Carlos Zabala | Modified on 11/9/25 at 7:25 PM in NFL Picks

The Rams won in weeks six, seven, and nine, the last by a score of 34-10 against the Saints, with Matthew Stafford finding the reliable Davante Adams on two of his four touchdown passes that day. The Rams also put on another outstanding defensive effort, holding the Saints to 224 yards. With a 6-2 record, the Rams travel to Levi's Stadium to face the 49ers, with Los Angeles favored by six points in the betting odds.

In week nine, the 49ers bounced back from their previous loss at NRG Stadium against the Texans. In New York, the 49ers defeated the Texans 34-24, with Christian McCaffrey leading the way with 106 rushing yards and five catches for an additional 67 yards. It was a tremendous turnaround for the 49ers between weeks eight and nine, where they won; They attempted just 10 rushing plays against the Texans but successfully executed 39 rushing plays against the Giants.

The 49ers enter Week 10 with a long injury list, including QB Purdy, but as many as 20 players are either out due to injury or listed as questionable. The 49ers acquired defensive linemen Keion White and Clelin Ferrell midweek, and both debuted against the Giants in excellent form.