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Baltimore Orioles vs Minnesota Twins Prediction & Picks - MLB

USA - MLB

Baltimore Orioles
5/6/25 18:40
Minnesota Twins

Prediction:

 

Minnesota Twins win both halves

-162
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 by Erik Gibbs in MLB Picks

The Baltimore Orioles and Minnesota Twins open their first head-to-head series of the season Tuesday night, with both teams entering on contrasting notes. After a day off Monday, they’ll kick off a three-game set in Minneapolis, where the Twins return home looking to build on recent momentum, while the Orioles try to regroup from a disappointing weekend.

Baltimore dropped two of three at home to the Kansas City Royals, a result that stung in the ultra-competitive AL East. The division is stacked this year, and the Orioles have fallen into last place, trailing the first-place Yankees by 5.5 games and the fourth-place Blue Jays by 2.5.

Their struggles are especially evident on offense, where the absence of consistent power has been a growing concern. Gunnar Henderson, last year’s standout rookie, has yet to recapture his form, leaving the middle of the order exposed. The Orioles have now lost two straight and look flat heading into this series.

Baltimore Orioles vs Minnesota Twins Form

Table

Teams % P W L
24
Minnesota Twins
Minnesota Twins
0.429 35 15 20
25
Baltimore Orioles
Baltimore Orioles
0.394 33 13 20

Baltimore Orioles and Minnesota Twins Latest Matches

Baltimore Orioles
Baltimore Orioles Latest matches
W L W W L L
Victories

3/6 (50%)

Defeats

3/6 (50%)

May 4, 2025 - MLB

Kansas City Royals
11 :  6
Baltimore Orioles

May 3, 2025 - MLB

Kansas City Royals
4 :  0
Baltimore Orioles

May 2, 2025 - MLB

Kansas City Royals
0 :  3
Baltimore Orioles

Apr 30, 2025 - MLB

New York Yankees
4 :  5
Baltimore Orioles

Apr 29, 2025 - MLB

New York Yankees
15 :  3
Baltimore Orioles

Apr 28, 2025 - MLB

New York Yankees
3 :  4
Baltimore Orioles
W L W W L L
Victories

3/6 (50%)

Defeats

3/6 (50%)

May 4, 2025 - MLB

Kansas City Royals
11 :  6
Baltimore Orioles

May 3, 2025 - MLB

Kansas City Royals
4 :  0
Baltimore Orioles

May 2, 2025 - MLB

Kansas City Royals
0 :  3
Baltimore Orioles

Apr 30, 2025 - MLB

New York Yankees
4 :  5
Baltimore Orioles

Apr 29, 2025 - MLB

New York Yankees
15 :  3
Baltimore Orioles

Apr 28, 2025 - MLB

New York Yankees
3 :  4
Baltimore Orioles
L L W L L L
Victories

1/6 (17%)

Defeats

5/6 (83%)

Apr 27, 2025 - MLB

Baltimore Orioles
0 :  7
Detroit Tigers

Apr 26, 2025 - MLB

Baltimore Orioles
2 :  6
Detroit Tigers

Apr 26, 2025 - MLB

Baltimore Orioles
3 :  4
Detroit Tigers

Apr 24, 2025 - MLB

Baltimore Orioles
2 :  1
Washington Nationals

Apr 23, 2025 - MLB

Baltimore Orioles
3 :  4
Washington Nationals

Apr 22, 2025 - MLB

Baltimore Orioles
0 :  7
Washington Nationals
Minnesota Twins
Minnesota Twins Latest matches
L L L L W W
Victories

2/6 (33%)

Defeats

4/6 (67%)

May 4, 2025 - MLB

Minnesota Twins
5 :  4
Boston Red Sox

May 3, 2025 - MLB

Minnesota Twins
4 :  3
Boston Red Sox

May 2, 2025 - MLB

Minnesota Twins
1 :  6
Boston Red Sox

May 1, 2025 - MLB

Minnesota Twins
3 :  4
Cleveland Guardians

Apr 30, 2025 - MLB

Minnesota Twins
2 :  4
Cleveland Guardians

Apr 29, 2025 - MLB

Minnesota Twins
1 :  2
Cleveland Guardians
W W L W W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Apr 27, 2025 - MLB

Los Angeles Angels
0 :  5
Minnesota Twins

Apr 26, 2025 - MLB

Los Angeles Angels
1 :  5
Minnesota Twins

Apr 25, 2025 - MLB

Los Angeles Angels
4 :  11
Minnesota Twins

Apr 24, 2025 - MLB

Chicago White Sox
3 :  0
Minnesota Twins

Apr 23, 2025 - MLB

Chicago White Sox
3 :  6
Minnesota Twins

Apr 22, 2025 - MLB

Chicago White Sox
2 :  4
Minnesota Twins
L L L L W W
Victories

2/6 (33%)

Defeats

4/6 (67%)

May 4, 2025 - MLB

Minnesota Twins
5 :  4
Boston Red Sox

May 3, 2025 - MLB

Minnesota Twins
4 :  3
Boston Red Sox

May 2, 2025 - MLB

Minnesota Twins
1 :  6
Boston Red Sox

May 1, 2025 - MLB

Minnesota Twins
3 :  4
Cleveland Guardians

Apr 30, 2025 - MLB

Minnesota Twins
2 :  4
Cleveland Guardians

Apr 29, 2025 - MLB

Minnesota Twins
1 :  2
Cleveland Guardians

Baltimore Orioles against Minnesota Twins : Head to Head (H2H)

Baltimore Orioles

100 %

Minnesota Twins

0 %

Mar 14, 2025 - MLB Spring Training

Minnesota Twins
0 :  10
Baltimore Orioles

Mar 9, 2025 - MLB Spring Training

Minnesota Twins
3 :  4
Baltimore Orioles

Mar 5, 2025 - MLB Spring Training

Baltimore Orioles
5 :  2
Minnesota Twins

Feb 28, 2025 - MLB Spring Training

Baltimore Orioles
13 :  10
Minnesota Twins

Sep 29, 2024 - MLB

Baltimore Orioles
6 :  2
Minnesota Twins

Sep 27, 2024 - MLB

Baltimore Orioles
7 :  2
Minnesota Twins

Baltimore Orioles - Minnesota Twins Key Points

  1. The Twins are 7-1 in their last 8 home games
  2. The Twins are 9-0 covering the run line in their last 9 Tuesday night games vs. American League teams
  3. The Orioles are 0-8 in their last 8 games at Target Field vs. teams with a losing record
  4. The Orioles are 1-6 covering the run line in their last 7 games vs. teams with a losing record

Our Baltimore Orioles vs Minnesota Twins Prediction

Minnesota comes in with a confidence boost after a gritty series win over the Red Sox at Fenway. Though the Twins lost three of four in Cleveland to start their road trip, they managed to close it with back-to-back strong outings in Boston. Now back at Target Field — where they own a solid 9-6 record — the Twins will look to extend their success. Their road record sits at just 6-14, so getting back home could make a big difference.

The pitching matchup favors Minnesota as well. Pablo López has been one of their most reliable arms this season, posting a 2.45 ERA and looking sharp in most starts. He’ll be opposed by the Orioles’ Cade Povich, who hasn’t shown the same level of consistency and has struggled to find rhythm early in the year.

With Baltimore’s offense not firing and Povich on the mound, this could be a good spot for Minnesota’s lineup to wake up. Our prediction for Minnesota Twins vs. Baltimore Orioles: Twins to win.

Prediction:

 

Minnesota Twins win both halves

-162
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Baltimore Orioles vs Minnesota Twins Picks