Baltimore Orioles vs Cleveland Guardians Prediction & Picks - MLB

Prediction published on 7/22/25, 3:16 PM  by Erik Gibbs in MLB Picks

The Cleveland Guardians and Baltimore Orioles square off today at Progressive Field, with both clubs in very different positions in their respective divisions. While neither team leads their division, recent performances and trends point to a competitive matchup, especially given their contrasting forms and pitching situations.

The Orioles are firmly anchored at the bottom of the American League East. Struggling to keep pace in what’s historically been a tough division, Baltimore finds itself 14.5 games behind the Toronto Blue Jays for the division lead. Their playoff hopes are fading quickly as they sit 8.5 games out of a wild card spot.

Making matters worse, Baltimore has been largely ineffective on the road this season, with a record well below .500 away from Camden Yards. Their pitching staff has underperformed, and the offense hasn’t been able to pick up the slack consistently.

The Guardians, meanwhile, sit second in the AL Central. However, they trail the division-leading Detroit Tigers by more than 10 games, making a division title an uphill battle. That said, the Guardians are still very much alive in the wild card race, trailing the Boston Red Sox by just 3.5 games for the final postseason berth.

At home, Cleveland holds a 23-24 record—not ideal, but showing signs of improvement. Momentum is on their side after winning nine of their last 11 games, including Monday’s 10-5 victory over Baltimore.