Houston Texans vs Indianapolis Colts Prediction & Picks - NFL

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Houston Texans
11/30/25 13:00
Indianapolis Colts

Prediction:

 

Under 44.5

-110
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 by Bill Christy in NFL Picks

The top team in the AFC South will look to stay there this Sunday. The Indianapolis Colts (8-3) are that team and will be taking on the Houston Texans (6-5) in a divisional matchup. This will be the 1st of two meetings between the foes this season.

The Colts are coming off a rough 23-20 overtime loss to the Kansas City Chiefs last week. The loss was their 2nd in the last 3 games and may be showing some cracks in a team that many were touting as the favorites to win the AFC just a few short weeks ago. Jonathan Taylor was held to just 58 rushing yards in the loss, while no receiver surpassed 50 yards receiving. The defense allowed nearly 500 total yards, and while they held tight in the red zone, it was not enough to get the win.

Houston has won 3 games in a row after defeating the Bills last week. Davis Mills has been tremendous in replacing the injured CJ Stroud. He has thrown 5 touchdowns and just 1 interception over that 3-game winning streak. However, the defense was key in the last win as they held Josh Allen to just under 200 yards passing and picked him off twice.

If the Houston defense can replicate the efforts from last week, they could push this Colts team to the limit here on the road.

Houston Texans vs Indianapolis Colts Form

Table

Teams % P W D L
6
Indianapolis Colts
Indianapolis Colts
0.727 11 8 0 3
14
Houston Texans
Houston Texans
0.545 11 6 0 5

Houston Texans and Indianapolis Colts Latest Matches

Houston Texans
Houston Texans Latest matches
L W L W W W
Victories

4/6 (67%)

Draw

0/6 (0%)

Defeats

2/6 (33%)

Nov 20, 2025 - NFL

Buffalo Bills
19 :  23
Houston Texans

Nov 16, 2025 - NFL

Houston Texans
16 :  13
Tennessee Titans

Nov 9, 2025 - NFL

Jacksonville Jaguars
29 :  36
Houston Texans

Nov 2, 2025 - NFL

Denver Broncos
18 :  15
Houston Texans

Oct 26, 2025 - NFL

San Francisco 49ers
15 :  26
Houston Texans

Oct 20, 2025 - NFL

Houston Texans
19 :  27
Seattle Seahawks
L W W L W W
Victories

4/6 (67%)

Draw

0/6 (0%)

Defeats

2/6 (33%)

Nov 20, 2025 - NFL

Buffalo Bills
19 :  23
Houston Texans

Nov 9, 2025 - NFL

Jacksonville Jaguars
29 :  36
Houston Texans

Nov 2, 2025 - NFL

Denver Broncos
18 :  15
Houston Texans

Oct 26, 2025 - NFL

San Francisco 49ers
15 :  26
Houston Texans

Sep 28, 2025 - NFL

Tennessee Titans
0 :  26
Houston Texans

Sep 15, 2025 - NFL

Tampa Bay Buccaneers
20 :  19
Houston Texans
L L L W L W
Victories

2/6 (33%)

Draw

0/6 (0%)

Defeats

4/6 (67%)

Nov 16, 2025 - NFL

Houston Texans
16 :  13
Tennessee Titans

Oct 20, 2025 - NFL

Houston Texans
19 :  27
Seattle Seahawks

Oct 5, 2025 - NFL

Houston Texans
44 :  10
Baltimore Ravens

Sep 21, 2025 - NFL

Houston Texans
10 :  17
Jacksonville Jaguars

Sep 7, 2025 - NFL

Houston Texans
9 :  14
Los Angeles Rams

Jan 18, 2025 - NFL

Houston Texans
14 :  23
Kansas City Chiefs
Indianapolis Colts
Indianapolis Colts Latest matches
W W W L W L
Victories

4/6 (67%)

Draw

0/6 (0%)

Defeats

2/6 (33%)

Nov 23, 2025 - NFL

Indianapolis Colts
20 :  23
Kansas City Chiefs

Nov 9, 2025 - NFL

Atlanta Falcons
25 :  31
Indianapolis Colts

Nov 2, 2025 - NFL

Indianapolis Colts
20 :  27
Pittsburgh Steelers

Oct 26, 2025 - NFL

Tennessee Titans
14 :  38
Indianapolis Colts

Oct 19, 2025 - NFL

Indianapolis Colts
38 :  24
Los Angeles Chargers

Oct 12, 2025 - NFL

Arizona Cardinals
27 :  31
Indianapolis Colts
W W W W W W
Victories

6/6 (100%)

Draw

0/6 (0%)

Defeats

0/6 (0%)

Nov 9, 2025 - NFL

Atlanta Falcons
25 :  31
Indianapolis Colts

Oct 26, 2025 - NFL

Tennessee Titans
14 :  38
Indianapolis Colts

Oct 12, 2025 - NFL

Arizona Cardinals
27 :  31
Indianapolis Colts

Oct 5, 2025 - NFL

Las Vegas Raiders
6 :  40
Indianapolis Colts

Sep 14, 2025 - NFL

Denver Broncos
28 :  29
Indianapolis Colts

Sep 7, 2025 - NFL

Miami Dolphins
8 :  33
Indianapolis Colts
L W L W L L
Victories

2/6 (33%)

Draw

0/6 (0%)

Defeats

4/6 (67%)

Nov 23, 2025 - NFL

Indianapolis Colts
20 :  23
Kansas City Chiefs

Nov 2, 2025 - NFL

Indianapolis Colts
20 :  27
Pittsburgh Steelers

Oct 19, 2025 - NFL

Indianapolis Colts
38 :  24
Los Angeles Chargers

Sep 28, 2025 - NFL

Indianapolis Colts
20 :  27
Los Angeles Rams

Sep 21, 2025 - NFL

Indianapolis Colts
41 :  20
Tennessee Titans

Dec 29, 2024 - NFL

Indianapolis Colts
33 :  45
New York Giants

Houston Texans against Indianapolis Colts : Head to Head (H2H)

Houston Texans

50 %

Draw

0 %

Indianapolis Colts

50 %

Oct 27, 2024 - NFL

Indianapolis Colts
20 :  23
Houston Texans

Sep 8, 2024 - NFL

Houston Texans
29 :  27
Indianapolis Colts

Jan 6, 2024 - NFL

Houston Texans
23 :  19
Indianapolis Colts

Sep 17, 2023 - NFL

Indianapolis Colts
31 :  20
Houston Texans

Dec 20, 2020 - NFL

Houston Texans
20 :  27
Indianapolis Colts

Jan 5, 2019 - NFL

Indianapolis Colts
21 :  7
Houston Texans

Houston Texans - Indianapolis Colts Key Points

  1. The total has gone UNDER in 7 of Houston’s last 10 games.
  2. The total has gone UNDER in 4 of Houston’s last 5 games when playing as the underdog.
  3. The total has gone UNDER in 7 of Indianapolis’ last 10 games against Houston.
  4. The total has gone UNDER in 12 of Indianapolis’ last 16 games when playing at home against Houston.

Our Houston Texans vs Indianapolis Colts Prediction

While the spread does indicate to us that Houston could be the play, it also tells us that the total is likely going to the under. The Texans will not be able to keep the game close if they are planning on trying to keep pace with the Colts offense. Instead, we believe they will keep this one close by keeping the total under the number.

Our prediction for Indianapolis Colts vs Houston Texans: Under 44.5

Prediction:

 

Under 44.5

-110
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All tips are fully researched and given in good faith, but profits cannot be guaranteed.

Houston Texans vs Indianapolis Colts Picks