Cincinnati Bengals vs Buffalo Bills Prediction & Picks - NFL

USA - NFL

Cincinnati Bengals
12/7/25 13:00
Buffalo Bills

Prediction:

 

The Bengals +5.5 points

-102
$150 offered for betting!

New customers only | Commercial content | 21+ age limit | T&Cs apply

 by Lou Aguila in NFL Picks

The Buffalo Bills look to stay in the hunt for the AFC East title as they take on the Cincinnati Bengals on Sunday at Highmark Stadium.

The Bills are -5.5 point favorites against the Bengals, who snapped a four-game losing streak last week.

Current Form:

Buffalo improved to 8-4 after trouncing the Pittsburgh Steelers 26-7 last week. Quarterback Josh Allen threw for 123 yards with one touchdown and one interception, and running back James Cook ran for 144 yards on 33 carries. But it was the Bills’ suffocating defense that made the biggest difference in this match. Buffalo, which averages 21.6 points allowed per game this season, contained the Steelers to just 166 total yards and 7 points.

Cincinnati ended its four-game skid with a 32-14 win over the Baltimore Ravens last week. Joe Burrow made his triumphant return from injury as the Pro Bowl quarterback outdueled Ravens quarterback Lamar Jackson, throwing for 261 yards with two touchdowns. The Bengals' defense also showed up, forcing the Ravens to commit 5 turnovers in this match.

Cincinnati Bengals vs Buffalo Bills Form

Table

Teams % P W D L
10
Buffalo Bills
Buffalo Bills
0.667 12 8 0 4
23
Cincinnati Bengals
Cincinnati Bengals
0.333 12 4 0 8

Cincinnati Bengals and Buffalo Bills Latest Matches

Cincinnati Bengals
Cincinnati Bengals Latest matches
W L L L L W
Victories

2/6 (33%)

Draw

0/6 (0%)

Defeats

4/6 (67%)

Nov 27, 2025 - NFL

Cincinnati Bengals
32 :  14
Baltimore Ravens

Nov 23, 2025 - NFL

New England Patriots
26 :  20
Cincinnati Bengals

Nov 16, 2025 - NFL

Cincinnati Bengals
12 :  34
Pittsburgh Steelers

Nov 2, 2025 - NFL

Chicago Bears
47 :  42
Cincinnati Bengals

Oct 26, 2025 - NFL

New York Jets
39 :  38
Cincinnati Bengals

Oct 16, 2025 - NFL

Pittsburgh Steelers
31 :  33
Cincinnati Bengals
W L W L L L
Victories

2/6 (33%)

Draw

0/6 (0%)

Defeats

4/6 (67%)

Nov 23, 2025 - NFL

New England Patriots
26 :  20
Cincinnati Bengals

Nov 2, 2025 - NFL

Chicago Bears
47 :  42
Cincinnati Bengals

Oct 26, 2025 - NFL

New York Jets
39 :  38
Cincinnati Bengals

Oct 16, 2025 - NFL

Pittsburgh Steelers
31 :  33
Cincinnati Bengals

Oct 5, 2025 - NFL

Detroit Lions
37 :  24
Cincinnati Bengals

Sep 14, 2025 - NFL

Jacksonville Jaguars
27 :  31
Cincinnati Bengals
W L L L L W
Victories

2/6 (33%)

Draw

0/6 (0%)

Defeats

4/6 (67%)

Nov 27, 2025 - NFL

Cincinnati Bengals
32 :  14
Baltimore Ravens

Nov 16, 2025 - NFL

Cincinnati Bengals
12 :  34
Pittsburgh Steelers

Oct 12, 2025 - NFL

Cincinnati Bengals
18 :  27
Green Bay Packers

Sep 29, 2025 - NFL

Cincinnati Bengals
3 :  28
Denver Broncos

Sep 21, 2025 - NFL

Cincinnati Bengals
10 :  48
Minnesota Vikings

Sep 7, 2025 - NFL

Cincinnati Bengals
17 :  16
Cleveland Browns
Buffalo Bills
Buffalo Bills Latest matches
W W L W L W
Victories

4/6 (67%)

Draw

0/6 (0%)

Defeats

2/6 (33%)

Nov 30, 2025 - NFL

Buffalo Bills
26 :  7
Pittsburgh Steelers

Nov 20, 2025 - NFL

Buffalo Bills
19 :  23
Houston Texans

Nov 16, 2025 - NFL

Tampa Bay Buccaneers
32 :  44
Buffalo Bills

Nov 9, 2025 - NFL

Buffalo Bills
13 :  30
Miami Dolphins

Nov 2, 2025 - NFL

Kansas City Chiefs
21 :  28
Buffalo Bills

Oct 26, 2025 - NFL

Buffalo Bills
40 :  9
Carolina Panthers
W W W L W W
Victories

5/6 (83%)

Draw

0/6 (0%)

Defeats

1/6 (17%)

Nov 16, 2025 - NFL

Tampa Bay Buccaneers
32 :  44
Buffalo Bills

Nov 2, 2025 - NFL

Kansas City Chiefs
21 :  28
Buffalo Bills

Oct 5, 2025 - NFL

New England Patriots
23 :  20
Buffalo Bills

Sep 28, 2025 - NFL

New Orleans Saints
19 :  31
Buffalo Bills

Sep 18, 2025 - NFL

Miami Dolphins
21 :  31
Buffalo Bills

Sep 7, 2025 - NFL

Baltimore Ravens
40 :  41
Buffalo Bills
W L W L L W
Victories

3/6 (50%)

Draw

0/6 (0%)

Defeats

3/6 (50%)

Nov 30, 2025 - NFL

Buffalo Bills
26 :  7
Pittsburgh Steelers

Nov 20, 2025 - NFL

Buffalo Bills
19 :  23
Houston Texans

Nov 9, 2025 - NFL

Buffalo Bills
13 :  30
Miami Dolphins

Oct 26, 2025 - NFL

Buffalo Bills
40 :  9
Carolina Panthers

Oct 13, 2025 - NFL

Buffalo Bills
14 :  24
Atlanta Falcons

Sep 14, 2025 - NFL

Buffalo Bills
30 :  10
New York Jets

Cincinnati Bengals against Buffalo Bills : Head to Head (H2H)

Cincinnati Bengals

67 %

Draw

0 %

Buffalo Bills

33 %

Nov 5, 2023 - NFL

Buffalo Bills
18 :  24
Cincinnati Bengals

Jan 22, 2023 - NFL

Cincinnati Bengals
27 :  10
Buffalo Bills

Sep 22, 2019 - NFL

Cincinnati Bengals
17 :  21
Buffalo Bills

Cincinnati Bengals - Buffalo Bills Key Points

  1. Buffalo is 4-2 ATS in its last 6 games.
  2. Buffalo is 13-6 SU in its last 19 games.
  3. Cincinnati is 5-1 ATS in its last 6 games against Buffalo.
  4. Cincinnati is 6-2 SU in its last 8 games against Buffalo.

Our Cincinnati Bengals vs Buffalo Bills Prediction

Fearless Forecast: I am taking the Bengals to cover the spread at +5.0 points. Joe Burrow’s fantastic return gives me confidence that Cincinnati will be a far tougher matchup for any team throughout the remainder of the season. Burrow is the engine of the Bengals' offense, and it showed right away with their win over the Ravens. As for the Bills, they are 15-1 in their last 16 home games and 4-2 ATS in their last 6 games. It would be intriguing to see how the Bills’ D will be able to shut down the Bengals now that they have their starting quarterback back. I believe Burrow will dazzle anew, giving the Bengals a shot at winning this match down the stretch.

Our betting prediction for the Cincinnati Bengals vs. the Buffalo Bills: The Bengals +5.5 points

Prediction:

 

The Bengals +5.5 points

-102
$150 offered for betting!

Grab an extra $150 for your Cincinnati Bengals vs Buffalo Bills wager!

Bet $5, Get $150

Get ready to experience the thrill of the game with FanDuel's exciting welcome offer, available for use on the Cincinnati Bengals vs Buffalo Bills matchup!

A minimum bet of $5 will qualify for $150 in bonus bets if your bet wins! This offer is a golden opportunity for new users. Don't miss out on this limited-time deal to enhance your sports betting experience with some extra oomph! Jump into the action today and let FanDuel take your sports engagement to the next level!

$150 available for Cincinnati Bengals vs Buffalo Bills

All tips are fully researched and given in good faith, but profits cannot be guaranteed.

Cincinnati Bengals vs Buffalo Bills Picks