Buffalo Bills vs Pittsburgh Steelers Prediction & Picks - NFL

USA - NFL

Buffalo Bills
11/30/25 16:25
Pittsburgh Steelers

Prediction:

 

Buffalo Bills ML

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 by Matt Lowrimore in NFL Picks

One of the important games on the NFL Week 13 Sunday slate will see the Pittsburgh Steelers take on the Buffalo Bills. Let’s take a look at the match statistics and predictions for this game between the Steelers and the Bills.

Buffalo enters this game with a record of 7-4, having most recently lost to the Houston Texans by a score of 23-19 in Week 12. The Bills’ offense had a total of 326 yards, while its defense allowed 261 yards. Quarterback Josh Allen threw for 253 yards and two interceptions, while running back James Cook III led the team in rushing with 116 yards.

As for Pittsburgh, they enter this game with a record of 6-5, having most recently lost to the Chicago Bears in Week 12 by a score of 31-28. The Steelers’ offense had a total of 345 yards, while its defense allowed 328 yards. Quarterback Mason Rudolph threw for 171 yards, one touchdown, and one interception, while running back Kenneth Gainwell led the team in rushing with 92 yards.

Buffalo Bills vs Pittsburgh Steelers Form

Table

Teams % P W D L
12
Buffalo Bills
Buffalo Bills
0.636 11 7 0 4
15
Pittsburgh Steelers
Pittsburgh Steelers
0.545 11 6 0 5

Buffalo Bills and Pittsburgh Steelers Latest Matches

Buffalo Bills
Buffalo Bills Latest matches
L W W L W L
Victories

3/6 (50%)

Draw

0/6 (0%)

Defeats

3/6 (50%)

Nov 20, 2025 - NFL

Buffalo Bills
19 :  23
Houston Texans

Nov 16, 2025 - NFL

Tampa Bay Buccaneers
32 :  44
Buffalo Bills

Nov 9, 2025 - NFL

Buffalo Bills
13 :  30
Miami Dolphins

Nov 2, 2025 - NFL

Kansas City Chiefs
21 :  28
Buffalo Bills

Oct 26, 2025 - NFL

Buffalo Bills
40 :  9
Carolina Panthers

Oct 13, 2025 - NFL

Buffalo Bills
14 :  24
Atlanta Falcons
W W W L W W
Victories

5/6 (83%)

Draw

0/6 (0%)

Defeats

1/6 (17%)

Nov 16, 2025 - NFL

Tampa Bay Buccaneers
32 :  44
Buffalo Bills

Nov 2, 2025 - NFL

Kansas City Chiefs
21 :  28
Buffalo Bills

Oct 5, 2025 - NFL

New England Patriots
23 :  20
Buffalo Bills

Sep 28, 2025 - NFL

New Orleans Saints
19 :  31
Buffalo Bills

Sep 18, 2025 - NFL

Miami Dolphins
21 :  31
Buffalo Bills

Sep 7, 2025 - NFL

Baltimore Ravens
40 :  41
Buffalo Bills
L W L W L L
Victories

2/6 (33%)

Draw

0/6 (0%)

Defeats

4/6 (67%)

Nov 20, 2025 - NFL

Buffalo Bills
19 :  23
Houston Texans

Nov 9, 2025 - NFL

Buffalo Bills
13 :  30
Miami Dolphins

Oct 26, 2025 - NFL

Buffalo Bills
40 :  9
Carolina Panthers

Oct 13, 2025 - NFL

Buffalo Bills
14 :  24
Atlanta Falcons

Sep 14, 2025 - NFL

Buffalo Bills
30 :  10
New York Jets

Jan 26, 2025 - NFL

Buffalo Bills
29 :  32
Kansas City Chiefs
Pittsburgh Steelers
Pittsburgh Steelers Latest matches
L L W L W L
Victories

2/6 (33%)

Draw

0/6 (0%)

Defeats

4/6 (67%)

Nov 23, 2025 - NFL

Pittsburgh Steelers
28 :  31
Chicago Bears

Nov 16, 2025 - NFL

Cincinnati Bengals
12 :  34
Pittsburgh Steelers

Nov 9, 2025 - NFL

Pittsburgh Steelers
10 :  25
Los Angeles Chargers

Nov 2, 2025 - NFL

Indianapolis Colts
20 :  27
Pittsburgh Steelers

Oct 26, 2025 - NFL

Green Bay Packers
35 :  25
Pittsburgh Steelers

Oct 16, 2025 - NFL

Pittsburgh Steelers
31 :  33
Cincinnati Bengals
L W W L W W
Victories

4/6 (67%)

Draw

0/6 (0%)

Defeats

2/6 (33%)

Nov 16, 2025 - NFL

Cincinnati Bengals
12 :  34
Pittsburgh Steelers

Nov 2, 2025 - NFL

Indianapolis Colts
20 :  27
Pittsburgh Steelers

Oct 26, 2025 - NFL

Green Bay Packers
35 :  25
Pittsburgh Steelers

Oct 12, 2025 - NFL

Cleveland Browns
9 :  23
Pittsburgh Steelers

Sep 28, 2025 - NFL

Minnesota Vikings
21 :  24
Pittsburgh Steelers

Sep 14, 2025 - NFL

Seattle Seahawks
31 :  17
Pittsburgh Steelers
L W W L L L
Victories

2/6 (33%)

Draw

0/6 (0%)

Defeats

4/6 (67%)

Nov 23, 2025 - NFL

Pittsburgh Steelers
28 :  31
Chicago Bears

Nov 9, 2025 - NFL

Pittsburgh Steelers
10 :  25
Los Angeles Chargers

Oct 16, 2025 - NFL

Pittsburgh Steelers
31 :  33
Cincinnati Bengals

Sep 21, 2025 - NFL

Pittsburgh Steelers
21 :  14
New England Patriots

Sep 7, 2025 - NFL

Pittsburgh Steelers
34 :  32
New York Jets

Jan 11, 2025 - NFL

Pittsburgh Steelers
14 :  28
Baltimore Ravens

Buffalo Bills against Pittsburgh Steelers : Head to Head (H2H)

Jan 15, 2024 - NFL

Pittsburgh Steelers
17 :  31
Buffalo Bills

Buffalo Bills - Pittsburgh Steelers Key Points

  1. The Bills are averaging 28.3 points per game
  2. The Bills are allowing 22.9 points per game
  3. The Steelers are averaging 24.9 points per game
  4. The Steelers are allowing 23.9 points per game

Our Buffalo Bills vs Pittsburgh Steelers Prediction

Buffalo is a small favorite in this game, but still looks to be the best betting option. The Bills have struggled at times this season, having lost to Miami and Houston over the last few weeks. However, they still have one of the better rosters in the NFL.

Pittsburgh, on the other hand, is dealing with multiple injuries, including to their quarterback, Aaron Rodgers. His status is still unknown, so if he is unable to play, Mason Rudolph is the likely option to play as a backup. 

He has never been a viable option at quarterback; therefore, because the Bills seem to be healthier and overall a better team, our Pittsburgh Steelers vs Buffalo Bills prediction is: Buffalo Bills ML.

Prediction:

 

Buffalo Bills ML

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All tips are fully researched and given in good faith, but profits cannot be guaranteed.

Buffalo Bills vs Pittsburgh Steelers Picks